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MGI:Jarid2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Jarid2 ( synonyms: Jmj, jumonji ) | |
| Protein Name(s) | jumonji, AT rich interactive domain 2, | |
| External Links | ||
| MGI | MGI:104813 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3589998 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97874 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:1096257 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856923 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2678857 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4441020 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3525051 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3715398 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4431292 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4436818 |
IPI: Inferred from Physical Interaction |
UniProtKB:P70351 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4441247 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2678857 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3589998 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856923 |
P |
From MGI |
||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0031061 |
negative regulation of histone methylation |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0031061 |
negative regulation of histone methylation |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035097 |
histone methyltransferase complex |
MGI:MGI:4441247 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:1932707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856923 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2678857 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4441247 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048536 |
spleen development |
MGI:MGI:1096257 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856923 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:1096257 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856923 |
P |
From MGI |
||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:4431292 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:4436818 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048863 |
stem cell differentiation |
MGI:MGI:4441020 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051574 |
positive regulation of histone H3-K9 methylation |
MGI:MGI:4441247 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
|
NOT |
GO:0032452 |
histone demethylase activity |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
F |
From MGI |
||
|
colocalizes_with |
GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
||
|
colocalizes_with |
GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Jung J et al. (2005) Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem 280: 30916-23 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Motoyama J et al. (1997) Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. Mech Dev 66: 27-37 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Kim TG et al. (2003) JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. J Biol Chem 278: 42247-55 PubMed GONUTS page
- ↑ 4.0 4.1 Pasini D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464: 306-10 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Peng JC et al. (2009) Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139: 1290-302 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Shen X et al. (2009) Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139: 1303-14 PubMed GONUTS page
- ↑ Kim TG et al. (2004) Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol 24: 10151-60 PubMed GONUTS page
- ↑ Mysliwiec MR et al. (2007) Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2. FEBS Lett 581: 2633-40 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Shirato H et al. (2009) A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem 284: 733-9 PubMed GONUTS page
- ↑ Kitajima K et al. (2001) A role of jumonji gene in proliferation but not differentiation of megakaryocyte lineage cells. Exp Hematol 29: 507-14 PubMed GONUTS page
