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MGI:Jam3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Jam3 ( synonyms: JAM-3, JAM-C, Jcam3 ) | |
| Protein Name(s) | junction adhesion molecule 3, | |
| External Links | ||
| MGI | MGI:1933825 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001525 |
angiogenesis |
MGI:MGI:5009412 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001780 |
neutrophil homeostasis |
MGI:MGI:3712391 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3055281 |
P |
From MGI |
||
| GO:0002250 |
adaptive immune response |
MGI:MGI:3842034 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3055281 |
P |
From MGI |
||
| GO:0002318 |
myeloid progenitor cell differentiation |
MGI:MGI:3836491 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0002523 |
leukocyte migration involved in inflammatory response |
MGI:MGI:3580973 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:3618936 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3622496 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3768317 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3054279 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3618936 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3699757 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3798380 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3798380 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:2386508 |
ISA: Inferred from Sequence Alignment |
EMBL:AF448478 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:3618936 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:3618936 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:3842034 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96611 |
P |
From MGI |
||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:3699757 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:3699757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96610 |
P |
From MGI |
||
| GO:0007283 |
spermatogenesis |
MGI:MGI:3054279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3055281 |
P |
From MGI |
||
| GO:0007286 |
spermatid development |
MGI:MGI:3054279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3055281 |
P |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:2386508 |
ISA: Inferred from Sequence Alignment |
EMBL:AF448478 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:3699757 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019226 |
transmission of nerve impulse |
MGI:MGI:3763982 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030010 |
establishment of cell polarity |
MGI:MGI:3699757 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030057 |
desmosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0033010 |
paranodal junction |
MGI:MGI:3763982 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042552 |
myelination |
MGI:MGI:3763982 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:3618936 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0044291 |
cell-cell contact zone |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:3618936 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0090022 |
regulation of neutrophil chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090138 |
regulation of actin cytoskeleton organization by cell-cell adhesion |
MGI:MGI:3054279 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3055281 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lamagna C et al. (2005) Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. Cancer Res 65: 5703-10 PubMed GONUTS page
- ↑ Imhof BA et al. (2007) Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice. J Pathol 212: 198-208 PubMed GONUTS page
- ↑ 3.0 3.1 Zimmerli C et al. (2009) Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory. J Immunol 182: 4728-36 PubMed GONUTS page
- ↑ Praetor A et al. (2009) Genetic deletion of JAM-C reveals a role in myeloid progenitor generation. Blood 113: 1919-28 PubMed GONUTS page
- ↑ Aurrand-Lions M et al. (2005) Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation. J Immunol 174: 6406-15 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Lamagna C et al. (2005) Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. Mol Biol Cell 16: 4992-5003 PubMed GONUTS page
- ↑ Mirza M et al. (2006) Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis. Exp Cell Res 312: 817-30 PubMed GONUTS page
- ↑ Fujita E et al. (2007) Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol 171: 1800-10 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Gliki G et al. (2004) Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature 431: 320-4 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 Mandicourt G et al. (2007) JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem 282: 1830-7 PubMed GONUTS page
- ↑ 11.0 11.1 Daniele LL et al. (2007) Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium. J Comp Neurol 505: 166-76 PubMed GONUTS page
- ↑ 12.0 12.1 Santoso S et al. (2002) The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 196: 679-91 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Scheiermann C et al. (2007) Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science 318: 1472-5 PubMed GONUTS page
