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MGI:Jak3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Jak3 | |
| Protein Name(s) | Janus kinase 3, | |
| External Links | ||
| MGI | MGI:99928 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0002731 |
negative regulation of dendritic cell cytokine production |
MGI:MGI:3719947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:67395 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1859033 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
F |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:1859033 |
IC: Inferred by Curator |
GO:0018108 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:67395 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
P |
From MGI |
||
| GO:0007167 |
enzyme linked receptor protein signaling pathway |
MGI:MGI:67395 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007243 |
intracellular protein kinase cascade |
MGI:MGI:67395 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:67395 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030183 |
B cell differentiation |
MGI:MGI:3655405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032693 |
negative regulation of interleukin-10 production |
MGI:MGI:3719947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032695 |
negative regulation of interleukin-12 production |
MGI:MGI:3719947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035771 |
interleukin-4-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042104 |
positive regulation of activated T cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042506 |
tyrosine phosphorylation of Stat5 protein |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:3719947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043029 |
T cell homeostasis |
MGI:MGI:3655405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045221 |
negative regulation of FasL biosynthetic process |
MGI:MGI:3655405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045626 |
negative regulation of T-helper 1 cell differentiation |
MGI:MGI:3719947 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045768 |
positive regulation of anti-apoptosis |
MGI:MGI:3619195 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3577956 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2675061 |
P |
From MGI |
||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048535 |
lymph node development |
MGI:MGI:1353335 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0050778 |
positive regulation of immune response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050868 |
negative regulation of T cell activation |
MGI:MGI:3655405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051928 |
positive regulation of calcium ion transport |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070232 |
regulation of T cell apoptotic process |
MGI:MGI:3655405 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070244 |
negative regulation of thymocyte apoptotic process |
MGI:MGI:3619195 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070669 |
response to interleukin-2 |
MGI:MGI:3619195 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0070670 |
response to interleukin-4 |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070670 |
response to interleukin-4 |
MGI:MGI:5009213 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0070672 |
response to interleukin-15 |
MGI:MGI:5009213 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0071104 |
response to interleukin-9 |
MGI:MGI:5009213 |
TAS: Traceable Author Statement |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Yamaoka K et al. (2005) Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106: 3227-33 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Witthuhn BA et al. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370: 153-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Sohn SJ et al. (1998) Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J Immunol 160: 2130-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Eynon EE et al. (1999) Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J Immunol 162: 1448-59 PubMed GONUTS page
- ↑ Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page
- ↑ Matsumoto M (1999) Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J Med Invest 46: 141-50 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Tortolani PJ et al. (1995) Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J Immunol 155: 5220-6 PubMed GONUTS page
