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MGI:Itk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Itk ( synonyms: Emt, Tcsk, Tsk ) | |
| Protein Name(s) | IL2 inducible T cell kinase, | |
| External Links | ||
| MGI | MGI:96621 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001816 |
cytokine production |
MGI:MGI:1335923 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001865 |
NK T cell differentiation |
MGI:MGI:3773943 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102960 |
P |
From MGI |
||
| GO:0001865 |
NK T cell differentiation |
MGI:MGI:3773943 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178928 |
P |
From MGI |
||
| GO:0002250 |
adaptive immune response |
MGI:MGI:1335923 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0829 |
F |
From MGI |
||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4352756 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005543 |
phospholipid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005829 |
cytosol |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0007202 |
activation of phospholipase C activity |
MGI:MGI:1335923 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0032609 |
interferon-gamma production |
MGI:MGI:3773943 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102960 |
P |
From MGI |
||
| GO:0032609 |
interferon-gamma production |
MGI:MGI:3773943 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178928 |
P |
From MGI |
||
| GO:0032633 |
interleukin-4 production |
MGI:MGI:3773943 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102960 |
P |
From MGI |
||
| GO:0032633 |
interleukin-4 production |
MGI:MGI:3773943 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178928 |
P |
From MGI |
||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050852 |
T cell receptor signaling pathway |
MGI:MGI:1335923 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Schaeffer EM et al. (1999) Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284: 638-41 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Felices M & Berg LJ (2008) The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol 180: 3007-18 PubMed GONUTS page
- ↑ Fu G et al. (2009) Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol 10: 848-56 PubMed GONUTS page
