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MGI:Itgb3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Itgb3 ( synonyms: CD61, platelet glycoprotein IIIa (GP3A) ) | |
| Protein Name(s) | integrin beta 3, | |
| External Links | ||
| MGI | MGI:96612 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001938 |
positive regulation of endothelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002687 |
positive regulation of leukocyte migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0003756 |
protein disulfide isomerase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:79483 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2667760 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3783912 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0007044 |
cell-substrate junction assembly |
MGI:MGI:2667760 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:3699757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1933825 |
P |
From MGI |
||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008277 |
regulation of G-protein coupled receptor protein signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0008305 |
integrin complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
C |
From MGI |
||
| GO:0008305 |
integrin complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2668377 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
C |
From MGI |
||
| GO:0010595 |
positive regulation of endothelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010763 |
positive regulation of fibroblast migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0010888 |
negative regulation of lipid storage |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014909 |
smooth muscle cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014911 |
positive regulation of smooth muscle cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0030168 |
platelet activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:3051967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032147 |
activation of protein kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032369 |
negative regulation of lipid transport |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033630 |
positive regulation of cell adhesion mediated by integrin |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0033690 |
positive regulation of osteoblast proliferation |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0034679 |
alpha9-beta1 integrin complex |
MGI:MGI:3766172 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0042277 |
peptide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
F |
From MGI |
||
| GO:0042470 |
melanosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043184 |
vascular endothelial growth factor receptor 2 binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0045672 |
positive regulation of osteoclast differentiation |
MGI:MGI:3766172 |
IC: Inferred by Curator |
GO:0005178 |
P |
From MGI |
||
| GO:0045715 |
negative regulation of low-density lipoprotein particle receptor biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045780 |
positive regulation of bone resorption |
MGI:MGI:3766172 |
IC: Inferred by Curator |
GO:0005178 |
P |
From MGI |
||
| GO:0045780 |
positive regulation of bone resorption |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0048858 |
cell projection morphogenesis |
MGI:MGI:3766172 |
IC: Inferred by Curator |
GO:0005178 |
P |
From MGI |
||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050748 |
negative regulation of lipoprotein metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050839 |
cell adhesion molecule binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0060548 |
negative regulation of cell death |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0070527 |
platelet aggregation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:0070527 |
platelet aggregation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071133 |
alpha9-beta1 integrin-ADAM8 complex |
MGI:MGI:3766172 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0072126 |
positive regulation of glomerular mesangial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
| GO:2000476 |
positive regulation of opioid receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
P |
From MGI |
||
|
contributes_to |
GO:0070051 |
fibrinogen binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_714942 |
F |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Wada J et al. (1996) Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J Cell Biol 132: 1161-76 PubMed GONUTS page
- ↑ 2.0 2.1 Jiang G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature 424: 334-7 PubMed GONUTS page
- ↑ Moser M et al. (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14: 325-30 PubMed GONUTS page
- ↑ Mandicourt G et al. (2007) JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem 282: 1830-7 PubMed GONUTS page
- ↑ Ferkowicz MJ et al. (2003) CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development 130: 4393-403 PubMed GONUTS page
- ↑ Rout UK et al. (2004) Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells. Dev Biol 268: 135-51 PubMed GONUTS page
- ↑ 7.0 7.1 Su JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J Biol Chem 285: 31325-36 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Rao H et al. (2006) Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res 21: 1657-65 PubMed GONUTS page
