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MGI:Itgb2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Itgb2 ( synonyms: 2E6, Cd18, Mac-1 beta ) | |
| Protein Name(s) | integrin beta 2, | |
| External Links | ||
| MGI | MGI:96611 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001948 |
glycoprotein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002523 |
leukocyte migration involved in inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR015812 |
F |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3838441 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3757613 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:2658799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861705 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:3842034 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96607 |
P |
From MGI |
||
| GO:0007159 |
leukocyte cell-cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0007159 |
leukocyte cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:3050945 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008305 |
integrin complex |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3664353 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:3618936 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1933825 |
P |
From MGI |
||
| GO:0016337 |
cell-cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030101 |
natural killer cell activation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0030593 |
neutrophil chemotaxis |
MGI:MGI:2658799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861705 |
P |
From MGI |
||
| GO:0030593 |
neutrophil chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
F |
From MGI |
||
| GO:0043542 |
endothelial cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0045121 |
membrane raft |
MGI:MGI:3757613 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045123 |
cellular extravasation |
MGI:MGI:2658799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861705 |
P |
From MGI |
||
| GO:0045123 |
cellular extravasation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
F |
From MGI |
||
| GO:0050730 |
regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050798 |
activated T cell proliferation |
MGI:MGI:3045560 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1861705 |
P |
From MGI |
||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
P |
From MGI |
||
|
contributes_to |
GO:0050839 |
cell adhesion molecule binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001032869 |
F |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Moser M et al. (2009) Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med 15: 300-5 PubMed GONUTS page
- ↑ 2.0 2.1 Krauss K & Altevogt P (1999) Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J Biol Chem 274: 36921-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Ding ZM et al. (1999) Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 163: 5029-38 PubMed GONUTS page
- ↑ Zimmerli C et al. (2009) Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory. J Immunol 182: 4728-36 PubMed GONUTS page
- ↑ Gakidis MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 166: 273-82 PubMed GONUTS page
- ↑ Kim SV et al. (2006) Modulation of cell adhesion and motility in the immune system by Myo1f. Science 314: 136-9 PubMed GONUTS page
- ↑ Lamagna C et al. (2005) Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. Mol Biol Cell 16: 4992-5003 PubMed GONUTS page
- ↑ Wu H et al. (2004) Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol 173: 297-306 PubMed GONUTS page
