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MGI:Itgb1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Itgb1 ( synonyms: beta1 integrin, CD29, Fnrb, Gm9863 ) | |
| Protein Name(s) | integrin beta 1 (fibronectin receptor beta), | |
| External Links | ||
| MGI | MGI:96610 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000082 |
G1/S transition of mitotic cell cycle |
MGI:MGI:2675790 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926498 |
P |
From MGI |
||
| GO:0001669 |
acrosomal vesicle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:75950 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154539 |
P |
From MGI |
||
| GO:0001708 |
cell fate specification |
MGI:MGI:84974 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154539 |
P |
From MGI |
||
| GO:0001894 |
tissue homeostasis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001948 |
glycoprotein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001968 |
fibronectin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002020 |
protease binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0002042 |
cell migration involved in sprouting angiogenesis |
MGI:MGI:3615102 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003779 |
actin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:75849 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:79483 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688344 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3710037 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3783912 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5050060 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005518 |
collagen binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005604 |
basement membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2451198 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2655007 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2677652 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005912 |
adherens junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007159 |
leukocyte cell-cell adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:3699757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1933825 |
P |
From MGI |
||
| GO:0007160 |
cell-matrix adhesion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007161 |
calcium-independent cell-matrix adhesion |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008277 |
regulation of G-protein coupled receptor protein signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3573843 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156945 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008305 |
integrin complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008354 |
germ cell migration |
MGI:MGI:1337540 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154538 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4439000 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4821247 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:64327 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010811 |
positive regulation of cell-substrate adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010976 |
positive regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014704 |
intercalated disc |
MGI:MGI:2154656 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019717 |
synaptosome |
MGI:MGI:2670471 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019900 |
kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030056 |
hemidesmosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031175 |
neuron projection development |
MGI:MGI:3836888 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031345 |
negative regulation of cell projection organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:1100182 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031594 |
neuromuscular junction |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032594 |
protein transport within lipid bilayer |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034667 |
alpha3-beta1 integrin complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034679 |
alpha9-beta1 integrin complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035748 |
myelin sheath abaxonal region |
MGI:MGI:4441217 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042277 |
peptide binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:1100182 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042383 |
sarcolemma |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043065 |
positive regulation of apoptotic process |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043236 |
laminin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045214 |
sarcomere organization |
MGI:MGI:84974 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154539 |
P |
From MGI |
||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:3573843 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2156945 |
P |
From MGI |
||
| GO:0045665 |
negative regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045807 |
positive regulation of endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051393 |
alpha-actinin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:2677652 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926498 |
P |
From MGI |
||
| GO:0055007 |
cardiac muscle cell differentiation |
MGI:MGI:84974 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2154539 |
P |
From MGI |
||
| GO:0070830 |
tight junction assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Tadayoni R et al. (2003) Erythrocyte and leukocyte dynamics in the retinal capillaries of diabetic mice. Exp Eye Res 77: 497-504 PubMed GONUTS page
- ↑ Fässler R & Meyer M (1995) Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9: 1896-908 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Fässler R et al. (1996) Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci 109 ( Pt 13): 2989-99 PubMed GONUTS page
- ↑ Uemura A et al. (2006) Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 116: 369-77 PubMed GONUTS page
- ↑ Cooper HM et al. (1991) The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin. J Cell Biol 115: 843-50 PubMed GONUTS page
- ↑ Wada J et al. (1996) Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. J Cell Biol 132: 1161-76 PubMed GONUTS page
- ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
- ↑ Suzuki K et al. (2007) Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446: 680-4 PubMed GONUTS page
- ↑ Moser M et al. (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14: 325-30 PubMed GONUTS page
- ↑ Uberti B et al. (2010) Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis. Oncogene 29: 6581-90 PubMed GONUTS page
- ↑ He ZY et al. (2003) None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol 254: 226-37 PubMed GONUTS page
- ↑ Sakai T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17: 926-40 PubMed GONUTS page
- ↑ 13.0 13.1 Aszodi A et al. (2003) Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev 17: 2465-79 PubMed GONUTS page
- ↑ Mandicourt G et al. (2007) JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. J Biol Chem 282: 1830-7 PubMed GONUTS page
- ↑ 15.0 15.1 Blaess S et al. (2004) Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24: 3402-12 PubMed GONUTS page
- ↑ Anderson R et al. (1999) Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development 126: 1655-64 PubMed GONUTS page
- ↑ Greene SB et al. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci 123: 606-18 PubMed GONUTS page
- ↑ Gu B et al. (2009) Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol 185: 811-26 PubMed GONUTS page
- ↑ Sutherland AE et al. (1993) Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119: 1175-86 PubMed GONUTS page
- ↑ Zhang JQ et al. (2001) Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart. Biochemistry 40: 14898-906 PubMed GONUTS page
- ↑ Chan CS et al. (2003) Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci 23: 7107-16 PubMed GONUTS page
- ↑ Ichikawa N et al. (2009) Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. J Cell Sci 122: 289-99 PubMed GONUTS page
- ↑ 23.0 23.1 van der Flier A et al. (1997) Spatial and temporal expression of the beta1D integrin during mouse development. Dev Dyn 210: 472-86 PubMed GONUTS page
- ↑ Ozçelik M et al. (2010) Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci 30: 4120-31 PubMed GONUTS page
