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MGI:Itch
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Itch ( synonyms: AIP4 ) | |
| Protein Name(s) | itchy, E3 ubiquitin protein ligase, | |
| External Links | ||
| MGI | MGI:1202301 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000151 |
ubiquitin ligase complex |
MGI:MGI:1196693 |
ISA: Inferred from Sequence Alignment |
C |
From MGI |
|||
| GO:0000209 |
protein polyubiquitination |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002669 |
positive regulation of T cell anergy |
MGI:MGI:3038342 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856404 |
P |
From MGI |
||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:1196693 |
ISA: Inferred from Sequence Alignment |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:3614328 |
ISA: Inferred from Sequence Alignment |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4459044 |
PANTHER:PTHR11254 |
F |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3774677 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2150845 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:3694584 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006464 |
protein modification process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
MGI:MGI:1196693 |
ISA: Inferred from Sequence Alignment |
P |
From MGI |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
MGI:MGI:3614328 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
MGI:MGI:3614328 |
ISA: Inferred from Sequence Alignment |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0009615 |
response to virus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0051 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016567 |
protein ubiquitination |
MGI:MGI:4459044 |
PANTHER:PTHR11254 |
P |
From MGI |
|||
| GO:0016567 |
protein ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:3774677 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0016881 |
acid-amino acid ligase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:3694584 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
MGI:MGI:3774677 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035519 |
protein K29-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043021 |
ribonucleoprotein complex binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045236 |
CXCR chemokine receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
MGI:MGI:3038342 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045732 |
positive regulation of protein catabolic process |
MGI:MGI:3038342 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856404 |
P |
From MGI |
||
| GO:0046329 |
negative regulation of JNK cascade |
MGI:MGI:3774677 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046642 |
negative regulation of alpha-beta T cell proliferation |
MGI:MGI:3038342 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856404 |
P |
From MGI |
||
| GO:0050687 |
negative regulation of defense response to virus |
MGI:MGI:4436832 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050687 |
negative regulation of defense response to virus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070534 |
protein K63-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070936 |
protein K48-linked ubiquitination |
MGI:MGI:3774677 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070936 |
protein K48-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090085 |
regulation of protein deubiquitination |
MGI:MGI:3774677 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Perry WL et al. (1998) The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet 18: 143-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Heissmeyer V et al. (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-65 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Rossi M et al. (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 24: 836-48 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Shembade N et al. (2008) The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol 9: 254-62 PubMed GONUTS page
- ↑ Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet 10: 1995-2011 PubMed GONUTS page
- ↑ 6.0 6.1 Oliver PM et al. (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity 25: 929-40 PubMed GONUTS page
- ↑ You F et al. (2009) PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol 10: 1300-8 PubMed GONUTS page
