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MGI:Isl2

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Isl2 ( synonyms: islet 2, islet-2 )
Protein Name(s) insulin related protein 2 (islet 2),
External Links
MGI MGI:109156

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR009057

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

From MGI

GO:0005622

intracellular

MGI:MGI:1344237
PMID:10482234[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From MGI

GO:0005634

nucleus

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970

C

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970
InterPro:IPR001356

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0008270

zinc ion binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001781

F

From MGI

GO:0021520

spinal cord motor neuron cell fate specification

MGI:MGI:4356383
PMID:19666821[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:102673

P

From MGI

GO:0021524

visceral motor neuron differentiation

MGI:MGI:3041365
PMID:14766174[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:101791

P

From MGI

GO:0021524

visceral motor neuron differentiation

MGI:MGI:3041365
PMID:14766174[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046260

P

From MGI

GO:0031290

retinal ganglion cell axon guidance

MGI:MGI:3513624
PMID:15537545[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046260

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970
InterPro:IPR001356

F

From MGI

GO:0045665

negative regulation of neuron differentiation

MGI:MGI:3041365
PMID:14766174[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:101791

P

From MGI

GO:0045665

negative regulation of neuron differentiation

MGI:MGI:3041365
PMID:14766174[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046260

P

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0048663

neuron fate commitment

MGI:MGI:3041365
PMID:14766174[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:101791

P

From MGI

GO:0048663

neuron fate commitment

MGI:MGI:3041365
PMID:14766174[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3046260

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Arber, S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23 659-74 PubMed GONUTS page
  2. Song, MR et al. (2009) Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development 136 2923-32 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Thaler, JP et al. (2004) A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron 41 337-50 PubMed GONUTS page
  4. Pak, W et al. (2004) Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding. Cell 119 567-78 PubMed GONUTS page
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