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MGI:Ireb2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ireb2 ( synonyms: D9Ertd85e, Irp2 ) | |
| Protein Name(s) | iron responsive element binding protein 2, | |
| External Links | ||
| MGI | MGI:1928268 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003723 |
RNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1928265 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:3852644 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:3604177 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006417 |
regulation of translation |
MGI:MGI:3028434 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181660 |
P |
From MGI |
||
| GO:0006782 |
protoporphyrinogen IX biosynthetic process |
MGI:MGI:3695992 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181660 |
P |
From MGI |
||
| GO:0006879 |
cellular iron ion homeostasis |
MGI:MGI:1930376 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006879 |
cellular iron ion homeostasis |
MGI:MGI:3028434 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87879 |
P |
From MGI |
||
| GO:0006879 |
cellular iron ion homeostasis |
MGI:MGI:3028434 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181660 |
P |
From MGI |
||
| GO:0006879 |
cellular iron ion homeostasis |
MGI:MGI:3695992 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181660 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR015931 |
P |
From MGI |
||
| GO:0009791 |
post-embryonic development |
MGI:MGI:3772706 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87879 |
P |
From MGI |
||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:3772706 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87879 |
P |
From MGI |
||
| GO:0030350 |
iron-responsive element binding |
MGI:MGI:1928265 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030350 |
iron-responsive element binding |
MGI:MGI:3028434 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0030350 |
iron-responsive element binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030371 |
translation repressor activity |
MGI:MGI:1930376 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0034101 |
erythrocyte homeostasis |
MGI:MGI:3695992 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2181660 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050892 |
intestinal absorption |
MGI:MGI:3772706 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:87879 |
P |
From MGI |
||
| GO:0051536 |
iron-sulfur cluster binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0411 |
F |
From MGI |
||
| GO:0051539 |
4 iron, 4 sulfur cluster binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Henderson BR et al. (1993) Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements. J Biol Chem 268: 27327-34 PubMed GONUTS page
- ↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
- ↑ Patton SM et al. (2005) Subcellular localization of iron regulatory proteins to Golgi and ER membranes. J Cell Sci 118: 4365-73 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Meyron-Holtz EG et al. (2004) Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J 23: 386-95 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Cooperman SS et al. (2005) Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood 106: 1084-91 PubMed GONUTS page
- ↑ 6.0 6.1 LaVaute T et al. (2001) Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 27: 209-14 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Galy B et al. (2008) Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab 7: 79-85 PubMed GONUTS page
