MGI:Irak1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001959	regulation of cytokine-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2181508 PMID:12054681^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0723	F	From MGI
	GO:0004674	protein serine/threonine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005149	interleukin-1 receptor binding	MGI:MGI:3056874 PMID:15292196^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P13504	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1889886 PMID:10854325^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P22366 UniProtKB:Q9QZ06	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2388454 PMID:12370331^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BST6	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3687915 PMID:12566447^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q793I8	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688344 PMID:15102471^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P37889-1 UniProtKB:P70196 UniProtKB:Q3THG9	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5002402 PMID:21441935^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P22366	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441	F	From MGI
	GO:0005622	intracellular	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	C	From MGI
	GO:0005624	membrane fraction	MGI:MGI:3694380 PMID:16831874^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	C	From MGI
	GO:0005634	nucleus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0539	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000488	P	From MGI
	GO:0007250	activation of NF-kappaB-inducing kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0007254	JNK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	P	From MGI
	GO:0016301	kinase activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:3056874 PMID:15292196^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:2669022 PMID:12855817^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0032494	response to peptidoglycan	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:2669022 PMID:12855817^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0034134	toll-like receptor 2 signaling pathway	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0034134	toll-like receptor 2 signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0034142	toll-like receptor 4 signaling pathway	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	F	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:3843426 PMID:17379480^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043507	positive regulation of JUN kinase activity	MGI:MGI:3843426 PMID:17379480^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045087	innate immune response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0399	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4411947 PMID:19752193^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2178646 PMID:10549626^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:2181508 PMID:12054681^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	F	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001121027	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:2181508 PMID:12054681^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0051259	protein oligomerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0070498	interleukin-1-mediated signaling pathway	MGI:MGI:2181508 PMID:12054681^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070498	interleukin-1-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0070555	response to interleukin-1	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P51617	P	From MGI
	GO:0090370	negative regulation of cholesterol efflux	MGI:MGI:4411947 PMID:19752193^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Rosati O & Martin MU (2002) Identification and characterization of murine IRAK-M. Biochem Biophys Res Commun 293: 1472-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page
↑ Burns K et al. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2: 346-51 PubMed GONUTS page
↑ Yu KY et al. (2002) Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. J Immunol 169: 4075-8 PubMed GONUTS page
↑ Takatsuna H et al. (2003) Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem 278: 12144-50 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page
↑ Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page
↑ ^10.0 ^10.1 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ ^11.0 ^11.1 Su J et al. (2007) Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling. Cell Signal 19: 1596-601 PubMed GONUTS page
↑ ^12.0 ^12.1 Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-97 PubMed GONUTS page

[PMID:10549626-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page

[PMID:12054681-1] 2.0 ^2.1 ^2.2 ^2.3 Rosati O & Martin MU (2002) Identification and characterization of murine IRAK-M. Biochem Biophys Res Commun 293: 1472-7 PubMed GONUTS page

[PMID:15292196-2] 3.0 ^3.1 Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page

[PMID:10854325-3] Burns K et al. (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2: 346-51 PubMed GONUTS page

[PMID:12370331-4] Yu KY et al. (2002) Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. J Immunol 169: 4075-8 PubMed GONUTS page

[PMID:12566447-5] Takatsuna H et al. (2003) Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J Biol Chem 278: 12144-50 PubMed GONUTS page

[PMID:15102471-6] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:21441935-7] Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page

[PMID:16831874-8] Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page

[PMID:12855817-9] 10.0 ^10.1 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:17379480-10] 11.0 ^11.1 Su J et al. (2007) Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling. Cell Signal 19: 1596-601 PubMed GONUTS page

[PMID:19752193-11] 12.0 ^12.1 Maitra U et al. (2009) An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol 29: 5989-97 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Irak1 ( synonyms: Il1rak, IRAK-1, mPLK, Plpk )
Protein Name(s)	interleukin-1 receptor-associated kinase 1,
External Links
MGI	MGI:107420

MGI:Irak1

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