MGI:Insr

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0001933	negative regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0003007	heart morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR002011	F	From MGI
	GO:0004716	receptor signaling protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005009	insulin-activated receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0005009	insulin-activated receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0005159	insulin-like growth factor receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1201213 PMID:9447983^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q62417	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1334765 PMID:10196204^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JID9	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2681062 PMID:12917015^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VH2	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3045683 PMID:15169905^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O35716 UniProtKB:O35718	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3622508 PMID:16455755^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O08917 UniProtKB:P51637	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3847873 PMID:15664450^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q60760	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005768	endosome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005792	microsome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3042070 PMID:14562105^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	C	From MGI
	GO:0005899	insulin receptor complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	C	From MGI
	GO:0005901	caveola	MGI:MGI:3769949 PMID:16513830^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005901	caveola	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	C	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR002011	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0008286	insulin receptor signaling pathway	MGI:MGI:2447254 PMID:12488434^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	From MGI
	GO:0008286	insulin receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0008286	insulin receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:2387729 PMID:12101187^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	From MGI
	GO:0010310	regulation of hydrogen peroxide metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0010560	positive regulation of glycoprotein biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0016020	membrane	MGI:MGI:1201213 PMID:9447983^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0019087	transformation of host cell by virus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0019903	protein phosphatase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0023014	signal transduction by phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0030238	male sex determination	MGI:MGI:2680871 PMID:14628051^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0031017	exocrine pancreas development	MGI:MGI:2387729 PMID:12101187^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857204	P	From MGI
	GO:0031405	lipoic acid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0031994	insulin-like growth factor I binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0031995	insulin-like growth factor II binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0032147	activation of protein kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0032148	activation of protein kinase B activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0032410	negative regulation of transporter activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0032869	cellular response to insulin stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0034612	response to tumor necrosis factor	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0042169	SH2 domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0042327	positive regulation of phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0043423	3-phosphoinositide-dependent protein kinase binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0043548	phosphatidylinositol 3-kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0043559	insulin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0043559	insulin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0043560	insulin receptor substrate binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	F	From MGI
	GO:0043560	insulin receptor substrate binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0045202	synapse	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	C	From MGI
	GO:0045429	positive regulation of nitric oxide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0045725	positive regulation of glycogen biosynthetic process	MGI:MGI:4438697 PMID:20032056^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045725	positive regulation of glycogen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0045821	positive regulation of glycolysis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0045995	regulation of embryonic development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0046326	positive regulation of glucose import	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0048639	positive regulation of developmental growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0051290	protein heterotetramerization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P15127	P	From MGI
	GO:0051290	protein heterotetramerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0051425	PTB domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	F	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0060267	positive regulation of respiratory burst	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P06213	P	From MGI
	GO:0071363	cellular response to growth factor stimulus	MGI:MGI:4366664 PMID:19744960^[13]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page
↑ Moodie SA et al. (1999) Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 274: 11186-93 PubMed GONUTS page
↑ MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page
↑ Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page
↑ Fecchi K et al. (2006) Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. FASEB J 20: 705-7 PubMed GONUTS page
↑ Mori K et al. (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol 230: 39-50 PubMed GONUTS page
↑ Bogan JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727-33 PubMed GONUTS page
↑ Lu X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147: 3123-32 PubMed GONUTS page
↑ Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page
↑ ^10.0 ^10.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page
↑ Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page
↑ Liang L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151: 741-7 PubMed GONUTS page
↑ Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page

[PMID:9447983-0] 1.0 ^1.1 Ribon V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol 18: 872-9 PubMed GONUTS page

[PMID:10196204-1] Moodie SA et al. (1999) Identification of the APS protein as a novel insulin receptor substrate. J Biol Chem 274: 11186-93 PubMed GONUTS page

[PMID:12917015-2] MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page

[PMID:15169905-3] Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page

[PMID:16455755-4] Fecchi K et al. (2006) Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells. FASEB J 20: 705-7 PubMed GONUTS page

[PMID:15664450-5] Mori K et al. (2005) Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol 230: 39-50 PubMed GONUTS page

[PMID:14562105-6] Bogan JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425: 727-33 PubMed GONUTS page

[PMID:16513830-7] Lu X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147: 3123-32 PubMed GONUTS page

[PMID:12488434-8] Kitamura T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110: 1839-47 PubMed GONUTS page

[PMID:12101187-9] 10.0 ^10.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page

[PMID:14628051-10] Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page

[PMID:20032056-11] Liang L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151: 741-7 PubMed GONUTS page

[PMID:19744960-12] Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Insr ( synonyms: CD220, IR, IR-A, IR-B )
Protein Name(s)	insulin receptor,
External Links
MGI	MGI:96575

MGI:Insr

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