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MGI:Insig2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Insig2 ( synonyms: Insig-2 ) | |
| Protein Name(s) | insulin induced gene 2, | |
| External Links | ||
| MGI | MGI:1920249 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:2388133 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q925C2 |
F |
From MGI |
||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_835192 |
C |
From MGI |
||
| GO:0006629 |
lipid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0443 |
P |
From MGI |
||
| GO:0006641 |
triglyceride metabolic process |
MGI:MGI:3603108 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0006695 |
cholesterol biosynthetic process |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0006991 |
response to sterol depletion |
MGI:MGI:2388215 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_835192 |
F |
From MGI |
||
| GO:0008202 |
steroid metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0753 |
P |
From MGI |
||
| GO:0008203 |
cholesterol metabolic process |
MGI:MGI:3603108 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0010894 |
negative regulation of steroid biosynthetic process |
MGI:MGI:3603108 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016126 |
sterol biosynthetic process |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0030967 |
ER-nuclear sterol response pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032937 |
SREBP-SCAP-Insig complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0042474 |
middle ear morphogenesis |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0045717 |
negative regulation of fatty acid biosynthetic process |
MGI:MGI:3603108 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0060021 |
palate development |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
||
| GO:0060363 |
cranial suture morphogenesis |
MGI:MGI:3689278 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1916289 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yabe D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 99: 12753-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Engelking LJ et al. (2005) Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-98 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Engelking LJ et al. (2006) Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest 116: 2356-65 PubMed GONUTS page
- ↑ Fernández A et al. (2002) Physical and linkage mapping of the porcine pink-eye dilution gene ( OCA2 ). Anim Genet 33: 392-4 PubMed GONUTS page
