GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Inppl1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Inppl1 ( synonyms: SHIP2 ) | |
| Protein Name(s) | inositol polyphosphate phosphatase-like 1, | |
| External Links | ||
| MGI | MGI:1333787 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003779 |
actin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0009 |
F |
From MGI |
||
| GO:0004445 |
inositol-polyphosphate 5-phosphatase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2675875 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
F |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:2675875 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:2675875 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006006 |
glucose metabolic process |
MGI:MGI:3530571 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3531322 |
P |
From MGI |
||
| GO:0006897 |
endocytosis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007015 |
actin filament organization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0008156 |
negative regulation of DNA replication |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:2675875 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009791 |
post-embryonic development |
MGI:MGI:3530571 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3531322 |
P |
From MGI |
||
| GO:0010629 |
negative regulation of gene expression |
MGI:MGI:3528799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3530363 |
P |
From MGI |
||
| GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0010977 |
negative regulation of neuron projection development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016311 |
dephosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0017124 |
SH3 domain binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0729 |
F |
From MGI |
||
| GO:0030027 |
lamellipodium |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
C |
From MGI |
||
| GO:0032868 |
response to insulin stimulus |
MGI:MGI:3530571 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3531322 |
P |
From MGI |
||
| GO:0032957 |
inositol trisphosphate metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0042169 |
SH2 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043407 |
negative regulation of MAP kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0043569 |
negative regulation of insulin-like growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0044255 |
cellular lipid metabolic process |
MGI:MGI:3528799 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3530363 |
P |
From MGI |
||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_075233 |
P |
From MGI |
||
| GO:0046854 |
phosphatidylinositol phosphorylation |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gagnon A et al. (2003) Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. J Cell Physiol 197: 243-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Clément S et al. (2001) The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409: 92-7 PubMed GONUTS page
- ↑ 3.0 3.1 Sleeman MW et al. (2005) Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 11: 199-205 PubMed GONUTS page
