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MGI:Ilk
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ilk ( synonyms: ESTM24 ) | |
| Protein Name(s) | integrin linked kinase, | |
| External Links | ||
| MGI | MGI:1195267 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001558 |
regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0001658 |
branching involved in ureteric bud morphogenesis |
MGI:MGI:3575981 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001954 |
positive regulation of cell-matrix adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1098082 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
F |
From MGI |
||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
F |
From MGI |
||
| GO:0005178 |
integrin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2447522 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3036971 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3511711 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0005925 |
focal adhesion |
MGI:MGI:2136490 |
ISA: Inferred from Sequence Alignment |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:2447522 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:3511711 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005925 |
focal adhesion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0007050 |
cell cycle arrest |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:1098082 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007229 |
integrin-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0007569 |
cell aging |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:2667260 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2668459 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0009966 |
regulation of signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0014912 |
negative regulation of smooth muscle cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0017124 |
SH3 domain binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
F |
From MGI |
||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0030424 |
axon |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0030513 |
positive regulation of BMP signaling pathway |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032288 |
myelin assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0032956 |
regulation of actin cytoskeleton organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0034446 |
substrate adhesion-dependent cell spreading |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0034446 |
substrate adhesion-dependent cell spreading |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042327 |
positive regulation of phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0043034 |
costamere |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0043195 |
terminal button |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0043198 |
dendritic shaft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0043206 |
fibril organization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
||
| GO:0043406 |
positive regulation of MAP kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
MGI:MGI:2655007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2655774 |
P |
From MGI |
||
| GO:0045663 |
positive regulation of myoblast differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:5009350 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045773 |
positive regulation of axon extension |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048662 |
negative regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0048812 |
neuron projection morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0050772 |
positive regulation of axonogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0051291 |
protein heterooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
P |
From MGI |
||
| GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
colocalizes_with |
GO:0001725 |
stress fiber |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_596900 |
C |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Leung-Hagesteijn C et al. (2005) Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol 25: 3648-57 PubMed GONUTS page
- ↑ 2.0 2.1 Li F et al. (1997) Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim Biophys Acta 1358: 215-20 PubMed GONUTS page
- ↑ 3.0 3.1 Zhang Y et al. (2002) Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci 115: 4777-86 PubMed GONUTS page
- ↑ Sorenson CM (2004) Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J Biol Chem 279: 11368-74 PubMed GONUTS page
- ↑ 5.0 5.1 Bock-Marquette I et al. (2004) Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-72 PubMed GONUTS page
- ↑ Nikolopoulos SN & Turner CE (2001) Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J Biol Chem 276: 23499-505 PubMed GONUTS page
- ↑ Terpstra L et al. (2003) Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 162: 139-48 PubMed GONUTS page
- ↑ 8.0 8.1 Su JL et al. (2010) CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway. J Biol Chem 285: 31325-36 PubMed GONUTS page
- ↑ Sakai T et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17: 926-40 PubMed GONUTS page
