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MGI:Il7r
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Il7r ( synonyms: CD127, IL-7 receptor alpha chain, IL-7Ralpha ) | |
| Protein Name(s) | interleukin 7 receptor, | |
| External Links | ||
| MGI | MGI:96562 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000902 |
cell morphogenesis |
MGI:MGI:3581459 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98936 |
P |
From MGI |
||
| GO:0001915 |
negative regulation of T cell mediated cytotoxicity |
MGI:MGI:893318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0002377 |
immunoglobulin production |
MGI:MGI:3581459 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98936 |
P |
From MGI |
||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004896 |
cytokine receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008361 |
regulation of cell size |
MGI:MGI:3581459 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008361 |
regulation of cell size |
MGI:MGI:3581459 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98936 |
P |
From MGI |
||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:2670545 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3054293 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3581459 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:3829828 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4415096 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:3829828 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016049 |
cell growth |
MGI:MGI:893318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0030217 |
T cell differentiation |
MGI:MGI:893318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0033089 |
positive regulation of T cell differentiation in thymus |
MGI:MGI:893320 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0042100 |
B cell proliferation |
MGI:MGI:3581459 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98936 |
P |
From MGI |
||
| GO:0042100 |
B cell proliferation |
MGI:MGI:3581459 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0048535 |
lymph node development |
MGI:MGI:2660934 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0048872 |
homeostasis of number of cells |
MGI:MGI:3581459 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98936 |
P |
From MGI |
||
| GO:0048872 |
homeostasis of number of cells |
MGI:MGI:893318 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
||
| GO:0048872 |
homeostasis of number of cells |
MGI:MGI:893320 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857198 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Erlandsson L et al. (2005) Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol 35: 1969-76 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Maraskovsky E et al. (1997) Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell 89: 1011-9 PubMed GONUTS page
- ↑ Nemeth MJ et al. (2003) Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood 102: 1298-306 PubMed GONUTS page
- ↑ Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
- ↑ 5.0 5.1 Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol 38: 2806-20 PubMed GONUTS page
- ↑ Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
- ↑ 7.0 7.1 Akashi K et al. (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89: 1033-41 PubMed GONUTS page
- ↑ Luther SA et al. (2003) Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med 197: 1191-8 PubMed GONUTS page
