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MGI:Il6st
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Il6st ( synonyms: CD130, D13Ertd699e, gp130 ) | |
| Protein Name(s) | interleukin 6 signal transducer, | |
| External Links | ||
| MGI | MGI:96560 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004897 |
ciliary neurotrophic factor receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004915 |
interleukin-6 receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005127 |
ciliary neurotrophic factor receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3614252 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005896 |
interleukin-6 receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005900 |
oncostatin-M receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005977 |
glycogen metabolic process |
MGI:MGI:1335676 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176787 |
P |
From MGI |
||
| GO:0006642 |
triglyceride mobilization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2387739 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3039221 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2684607 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008593 |
regulation of Notch signaling pathway |
MGI:MGI:2651972 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:1932624 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0014911 |
positive regulation of smooth muscle cell migration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019838 |
growth factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:2157598 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032809 |
neuronal cell body membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034097 |
response to cytokine stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042102 |
positive regulation of T cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042511 |
positive regulation of tyrosine phosphorylation of Stat1 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:2157598 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044297 |
cell body |
MGI:MGI:2157598 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048711 |
positive regulation of astrocyte differentiation |
MGI:MGI:1343608 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048861 |
leukemia inhibitory factor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051481 |
reduction of cytosolic calcium ion concentration |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070102 |
interleukin-6-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070102 |
interleukin-6-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070104 |
negative regulation of interleukin-6-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070106 |
interleukin-27-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070110 |
ciliary neurotrophic factor receptor complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
contributes_to |
GO:0004921 |
interleukin-11 receptor activity |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
F |
From MGI |
||
|
contributes_to |
GO:0019970 |
interleukin-11 binding |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Song H & Lim H (2006) Evidence for heterodimeric association of leukemia inhibitory factor (LIF) receptor and gp130 in the mouse uterus for LIF signaling during blastocyst implantation. Reproduction 131: 341-9 PubMed GONUTS page
- ↑ Kamiya A et al. (1999) Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J 18: 2127-36 PubMed GONUTS page
- ↑ Matsui T et al. (2002) STAT3 down-regulates the expression of cyclin D during liver development. J Biol Chem 277: 36167-73 PubMed GONUTS page
- ↑ Derouet D et al. (2004) Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A 101: 4827-32 PubMed GONUTS page
- ↑ Chojnacki A et al. (2003) Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci 23: 1730-41 PubMed GONUTS page
- ↑ Melnick M et al. (2001) Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs 168: 233-45 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Hilton DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Ha BK & King JS (2000) Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat 19: 129-41 PubMed GONUTS page
- ↑ Nakashima K et al. (1999) Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS Lett 457: 43-6 PubMed GONUTS page
