MGI:Il6

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001781	neutrophil apoptotic process	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001781	neutrophil apoptotic process	MGI:MGI:2673020 PMID:12925700^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857197	P	From MGI
	GO:0001781	neutrophil apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0002384	hepatic immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0002675	positive regulation of acute inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0005102	receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:49305 PMID:1373998^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005138	interleukin-6 receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	F	From MGI
	GO:0005138	interleukin-6 receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	F	From MGI
	GO:0005138	interleukin-6 receptor binding	MGI:MGI:50330 PMID:1312474^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:1266961 PMID:9637508^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O54824	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003573 InterPro:IPR003574	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1929334 PMID:11016935^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2176422 PMID:11894098^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2178646 PMID:10549626^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2669022 PMID:12855817^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3029067 PMID:14764707^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3051177 PMID:15240714^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3056874 PMID:15292196^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3528786 PMID:15692051^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3608246 PMID:16236719^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3695768 PMID:16275384^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3761982 PMID:17693256^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3775161 PMID:18261938^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3806198 PMID:18559975^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3829555 PMID:17277142^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3839525 PMID:19139201^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:49296 PMID:1577194^[20]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005623	cell	MGI:MGI:3807360 PMID:18719127^[21]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005896	interleukin-6 receptor complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	C	From MGI
	GO:0006469	negative regulation of protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0006953	acute-phase response	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0011	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0006955	immune response	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003573 InterPro:IPR003574	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0008360	regulation of cell shape	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0009611	response to wounding	MGI:MGI:3844151 PMID:19404405^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:1932624 PMID:11275690^[23]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0010574	regulation of vascular endothelial growth factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0016049	cell growth	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0031018	endocrine pancreas development	MGI:MGI:3807360 PMID:18719127^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0031175	neuron projection development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0032722	positive regulation of chemokine production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0032966	negative regulation of collagen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0033160	positive regulation of protein import into nucleus, translocation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0042110	T cell activation	MGI:MGI:3817792 PMID:18792410^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:98725	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:3771668 PMID:18056981^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0042832	defense response to protozoan	MGI:MGI:3695633 PMID:17109471^[26]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:1932624 PMID:11275690^[23]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0043526	neuroprotection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045079	negative regulation of chemokine biosynthetic process	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045079	negative regulation of chemokine biosynthetic process	MGI:MGI:2673020 PMID:12925700^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857197	P	From MGI
	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045429	positive regulation of nitric oxide biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045454	cell redox homeostasis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045630	positive regulation of T-helper 2 cell differentiation	MGI:MGI:2450484 PMID:12594267^[27]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045666	positive regulation of neuron differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045721	negative regulation of gluconeogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045727	positive regulation of translation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0045768	positive regulation of anti-apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:49305 PMID:1373998^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4355633 PMID:19666510^[28]	IGI: Inferred from Genetic Interaction	MGI:MGI:96542 MGI:MGI:96543	P	From MGI
	GO:0046427	positive regulation of JAK-STAT cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0046427	positive regulation of JAK-STAT cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0046716	muscle cell homeostasis	MGI:MGI:3771668 PMID:18056981^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:88039	P	From MGI
	GO:0046888	negative regulation of hormone secretion	MGI:MGI:71439 PMID:7867561^[29]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048635	negative regulation of muscle organ development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:1932624 PMID:11275690^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:1932624 PMID:11275690^[23]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050710	negative regulation of cytokine secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0050871	positive regulation of B cell activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0051024	positive regulation of immunoglobulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0051384	response to glucocorticoid stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0051607	defense response to virus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0051971	positive regulation of transmission of nerve impulse	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
	GO:0060445	branching involved in salivary gland morphogenesis	MGI:MGI:1932624 PMID:11275690^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060445	branching involved in salivary gland morphogenesis	MGI:MGI:1932624 PMID:11275690^[23]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	MGI:MGI:1932624 PMID:11275690^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070091	glucagon secretion	MGI:MGI:3807360 PMID:18719127^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070102	interleukin-6-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0070102	interleukin-6-mediated signaling pathway	MGI:MGI:50330 PMID:1312474^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070301	cellular response to hydrogen peroxide	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05231	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20607	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 McLoughlin RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112: 598-607 PubMed GONUTS page
↑ ^2.0 ^2.1 Itoh Y et al. (1992) Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin Exp Immunol 88: 356-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Fiorillo MT et al. (1992) Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction. Eur J Immunol 22: 799-804 PubMed GONUTS page
↑ Keane J et al. (1998) Conservation of structure and function between human and murine IL-16. J Immunol 160: 5945-54 PubMed GONUTS page
↑ Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-32 PubMed GONUTS page
↑ Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page
↑ Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page
↑ Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page
↑ McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
↑ Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page
↑ Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page
↑ Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page
↑ Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page
↑ Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page
↑ Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-31 PubMed GONUTS page
↑ Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
↑ Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page
↑ De M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev Biol 151: 297-305 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Ellingsgaard H et al. (2008) Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A 105: 13163-8 PubMed GONUTS page
↑ Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Melnick M et al. (2001) Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs 168: 233-45 PubMed GONUTS page
↑ van Hamburg JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol 38: 2573-86 PubMed GONUTS page
↑ ^25.0 ^25.1 Baltgalvis KA et al. (2008) Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol 294: R393-401 PubMed GONUTS page
↑ Wu W et al. (2006) Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides. Eur J Immunol 36: 3238-47 PubMed GONUTS page
↑ Kusam S et al. (2003) Inhibition of Th2 differentiation and GATA-3 expression by BCL-6. J Immunol 170: 2435-41 PubMed GONUTS page
↑ Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page
↑ Yamaguchi M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136: 1072-8 PubMed GONUTS page

[PMID:12925700-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 McLoughlin RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112: 598-607 PubMed GONUTS page

[PMID:1373998-1] 2.0 ^2.1 Itoh Y et al. (1992) Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin Exp Immunol 88: 356-9 PubMed GONUTS page

[PMID:1312474-2] 3.0 ^3.1 Fiorillo MT et al. (1992) Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction. Eur J Immunol 22: 799-804 PubMed GONUTS page

[PMID:9637508-3] Keane J et al. (1998) Conservation of structure and function between human and murine IL-16. J Immunol 160: 5945-54 PubMed GONUTS page

[PMID:11016935-4] Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-32 PubMed GONUTS page

[PMID:11894098-5] Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page

[PMID:10549626-6] Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page

[PMID:12855817-7] Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:14764707-8] Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page

[PMID:15240714-9] McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page

[PMID:15292196-10] Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page

[PMID:15692051-11] Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page

[PMID:16236719-12] Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page

[PMID:16275384-13] Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page

[PMID:17693256-14] Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:18261938-15] Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page

[PMID:18559975-16] Novitskiy SV et al. (2008) Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-31 PubMed GONUTS page

[PMID:17277142-17] Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page

[PMID:19139201-18] Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Il6 ( synonyms: Il-6 )
Protein Name(s)	interleukin 6,
External Links
MGI	MGI:96559

MGI:Il6

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