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MGI:Il3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Il3 ( synonyms: BPA, Csfmu, HCGF, Il-3, MCGF, PSF ) | |
| Protein Name(s) | interleukin 3, | |
| External Links | ||
| MGI | MGI:96552 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001558 |
regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001666 |
response to hypoxia |
MGI:MGI:3709696 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002763 |
positive regulation of myeloid leukocyte differentiation |
MGI:MGI:49671 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
From MGI |
||
| GO:0002763 |
positive regulation of myeloid leukocyte differentiation |
MGI:MGI:63529 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
From MGI |
||
| GO:0005125 |
cytokine activity |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:2670544 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3577955 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:49581 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:67770 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:72688 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005135 |
interleukin-3 receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:63529 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006110 |
regulation of glycolysis |
MGI:MGI:3709696 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106918 |
P |
From MGI |
||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:2670544 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:49581 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:63529 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96974 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:69257 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:72688 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009725 |
response to hormone stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:1275871 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010507 |
negative regulation of autophagy |
MGI:MGI:3575206 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0019221 |
cytokine-mediated signaling pathway |
MGI:MGI:67770 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030097 |
hemopoiesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033026 |
negative regulation of mast cell apoptotic process |
MGI:MGI:2670544 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0033028 |
myeloid cell apoptotic process |
MGI:MGI:892837 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035162 |
embryonic hemopoiesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035304 |
regulation of protein dephosphorylation |
MGI:MGI:2675215 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2675215 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:3057092 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045740 |
positive regulation of DNA replication |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045885 |
positive regulation of survival gene product expression |
MGI:MGI:3577955 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045885 |
positive regulation of survival gene product expression |
MGI:MGI:72688 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046330 |
positive regulation of JNK cascade |
MGI:MGI:3032484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046330 |
positive regulation of JNK cascade |
MGI:MGI:3032484 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:1859033 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:67770 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070668 |
positive regulation of mast cell proliferation |
MGI:MGI:2670544 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0070668 |
positive regulation of mast cell proliferation |
MGI:MGI:3605581 |
IDA: Inferred from Direct Assay |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Lum JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21: 1037-49 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Yu C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-40 PubMed GONUTS page
- ↑ Tsuji K et al. (1992) Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 79: 2855-60 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ploemacher RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7: 1374-80 PubMed GONUTS page
- ↑ 5.0 5.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Shelburne CP et al. (2003) Stat5 expression is critical for mast cell development and survival. Blood 102: 1290-7 PubMed GONUTS page
- ↑ 7.0 7.1 Kieslinger M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev 14: 232-44 PubMed GONUTS page
- ↑ 8.0 8.1 Okada S et al. (1992) Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp Hematol 20: 546-51 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Ito T et al. (1994) Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A 91: 7455-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Hilton DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Miyazaki T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-31 PubMed GONUTS page
- ↑ Traver D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9: 47-57 PubMed GONUTS page
- ↑ Lum JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-48 PubMed GONUTS page
- ↑ Barge RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett 409: 207-10 PubMed GONUTS page
- ↑ 15.0 15.1 Chiang CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol 23: 6350-62 PubMed GONUTS page
- ↑ Seo SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem 279: 42240-9 PubMed GONUTS page
- ↑ Ikeda K et al. (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol 137 Suppl 1: 45-50 PubMed GONUTS page
