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MGI:Il2ra

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Il2ra ( synonyms: CD25, IL-2R alpha chain, Il2r, Ly-43 )
Protein Name(s) interleukin 2 receptor, alpha chain,
External Links
MGI MGI:96549

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002437

inflammatory response to antigenic stimulus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI

GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0004911

interleukin-2 receptor activity

MGI:MGI:1889048
PMID:7584142[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

F

From MGI

GO:0004911

interleukin-2 receptor activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

F

From MGI

GO:0005515

protein binding

MGI:MGI:4887510
PMID:21217760[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q61508

F

From MGI

GO:0006924

activation-induced cell death of T cells

MGI:MGI:1889048
PMID:7584142[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0007219

Notch signaling pathway

MGI:MGI:5140640
PMID:21508411[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:1277162

P

From MGI

GO:0008144

drug binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

F

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1332382
PMID:10072077[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1355384
PMID:10760791[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1889048
PMID:7584142[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3039643
PMID:12867038[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3041277
PMID:14990792[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3051177
PMID:15240714[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3052401
PMID:15368291[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3054293
PMID:15294943[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3531056
PMID:15728238[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3581459
PMID:15909309[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3662823
PMID:16227984[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3686949
PMID:16973387[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3700459
PMID:16301745[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3803061
PMID:18641307[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3807624
PMID:18628982[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3813999
PMID:17082577[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3817792
PMID:18792410[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3818206
PMID:19008373[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3829828
PMID:18958875[21]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4358631
PMID:19723499[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:4415096
PMID:19934022[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5004747
PMID:21460847[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5140640
PMID:21508411[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:5296987
PMID:22072979[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:62368
PMID:7688139[26]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:64265
PMID:8262055[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:65397
PMID:8125140[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77314
PMID:7477352[29]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:81771
PMID:8755570[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:82508
PMID:8769481[31]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009986

cell surface

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

C

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0019976

interleukin-2 binding

MGI:MGI:64265
PMID:8262055[27]

IPI: Inferred from Physical Interaction

UniProtKB:P04351
UniProtKB:P01585

F

From MGI

GO:0038110

interleukin-2-mediated signaling pathway

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI

GO:0042102

positive regulation of T cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI

GO:0042104

positive regulation of activated T cell proliferation

MGI:MGI:1889048
PMID:7584142[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0042130

negative regulation of T cell proliferation

MGI:MGI:2670301
PMID:12702495[32]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0043029

T cell homeostasis

MGI:MGI:2670301
PMID:12702495[32]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:1889048
PMID:7584142[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0045582

positive regulation of T cell differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI

GO:0046013

regulation of T cell homeostatic proliferation

MGI:MGI:3662823
PMID:16227984[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0050672

negative regulation of lymphocyte proliferation

MGI:MGI:3662823
PMID:16227984[13]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0050687

negative regulation of defense response to virus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI

GO:0050728

negative regulation of inflammatory response

MGI:MGI:1889048
PMID:7584142[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0050728

negative regulation of inflammatory response

MGI:MGI:2670301
PMID:12702495[32]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857192

P

From MGI

GO:0050777

negative regulation of immune response

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P26897

P

From MGI


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Willerford DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-30 PubMed GONUTS page
  2. ↑ Li Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol 12: 178-85 PubMed GONUTS page
  3. ↑ 3.0 3.1 Hu MG et al. (2011) CDK6 kinase activity is required for thymocyte development. Blood 117: 6120-31 PubMed GONUTS page
  4. ↑ Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
  5. ↑ Mages HW et al. (2000) Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol 30: 1040-7 PubMed GONUTS page
  6. ↑ Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
  7. ↑ Carlyle JR et al. (2004) Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A 101: 3527-32 PubMed GONUTS page
  8. ↑ McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
  9. ↑ Ye Q et al. (2004) BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 34: 2750-9 PubMed GONUTS page
  10. ↑ Kang J et al. (2004) STAT5 is required for thymopoiesis in a development stage-specific manner. J Immunol 173: 2307-14 PubMed GONUTS page
  11. ↑ Mandal M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 201: 603-14 PubMed GONUTS page
  12. ↑ Erlandsson L et al. (2005) Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol 35: 1969-76 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-51 PubMed GONUTS page
  14. ↑ Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
  15. ↑ Chen Z et al. (2005) Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 202: 1387-97 PubMed GONUTS page
  16. ↑ Kisielow J et al. (2008) SCART scavenger receptors identify a novel subset of adult gammadelta T cells. J Immunol 181: 1710-6 PubMed GONUTS page
  17. ↑ Wang R et al. (2008) Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One 3: e2705 PubMed GONUTS page
  18. ↑ Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177: 6650-9 PubMed GONUTS page
  19. ↑ van Hamburg JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol 38: 2573-86 PubMed GONUTS page
  20. ↑ Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol 173: 1682-92 PubMed GONUTS page
  21. ↑ Jia J et al. (2008) E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol 38: 2806-20 PubMed GONUTS page
  22. ↑ Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
  23. ↑ Hosoya T et al. (2009) GATA-3 is required for early T lineage progenitor development. J Exp Med 206: 2987-3000 PubMed GONUTS page
  24. ↑ Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 12: 450-9 PubMed GONUTS page
  25. ↑ Nowell CS et al. (2011) Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7: e1002348 PubMed GONUTS page
  26. ↑ Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-12 PubMed GONUTS page
  27. ↑ 27.0 27.1 Zurawski SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J 12: 5113-9 PubMed GONUTS page
  28. ↑ Hubbe M & Altevogt P (1994) Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol 24: 731-7 PubMed GONUTS page
  29. ↑ Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page
  30. ↑ Bouvier G et al. (1996) Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development. Proc Natl Acad Sci U S A 93: 7877-81 PubMed GONUTS page
  31. ↑ Hazenbos WL et al. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5: 181-8 PubMed GONUTS page
  32. ↑ 32.0 32.1 32.2 Boone DL et al. (2003) Fas is not essential for lamina propria T lymphocyte homeostasis. Am J Physiol Gastrointest Liver Physiol 285: G382-8 PubMed GONUTS page
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