MGI:Il2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001933	negative regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0002903	negative regulation of B cell apoptotic process	MGI:MGI:892164 PMID:9184696^[1]	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	P	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:3577956 PMID:10485657^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:3822044 PMID:12874832^[3]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:49545 PMID:1588041^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005134	interleukin-2 receptor binding	MGI:MGI:1889048 PMID:7584142^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005134	interleukin-2 receptor binding	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	F	From MGI
	GO:0005134	interleukin-2 receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	F	From MGI
	GO:0005134	interleukin-2 receptor binding	MGI:MGI:49545 PMID:1588041^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005134	interleukin-2 receptor binding	MGI:MGI:64265 PMID:8262055^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000779	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1332382 PMID:10072077^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2671681 PMID:9492004^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3510555 PMID:11728336^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3693968 PMID:16769892^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3769991 PMID:8612131^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3822044 PMID:12874832^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3839525 PMID:19139201^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:62368 PMID:7688139^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:87443 PMID:1830926^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006955	immune response	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000779	P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000779	F	From MGI
	GO:0030246	carbohydrate binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	F	From MGI
	GO:0030890	positive regulation of B cell proliferation	MGI:MGI:892164 PMID:9184696^[1]	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	P	From MGI
	GO:0031851	kappa-type opioid receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	F	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:3834312 PMID:17213291^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:49545 PMID:1588041^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:1889048 PMID:7584142^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:3577956 PMID:10485657^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:87443 PMID:1830926^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	MGI:MGI:3577956 PMID:10485657^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P60568	P	From MGI
	GO:0043208	glycosphingolipid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	F	From MGI
	GO:0045582	positive regulation of T cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0045591	positive regulation of regulatory T cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0045822	negative regulation of heart contraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3577956 PMID:10485657^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046013	regulation of T cell homeostatic proliferation	MGI:MGI:3662823 PMID:16227984^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0048304	positive regulation of isotype switching to IgG isotypes	MGI:MGI:87443 PMID:1830926^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0050672	negative regulation of lymphocyte proliferation	MGI:MGI:3662823 PMID:16227984^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0050728	negative regulation of inflammatory response	MGI:MGI:63352 PMID:8402910^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0050728	negative regulation of inflammatory response	MGI:MGI:87442 PMID:7589135^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0051024	positive regulation of immunoglobulin secretion	MGI:MGI:87443 PMID:1830926^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857191	P	From MGI
	GO:0060999	positive regulation of dendritic spine development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17108	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Casey LS et al. (1992) IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J Immunol 148: 3418-26 PubMed GONUTS page
↑ ^5.0 ^5.1 Willerford DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-30 PubMed GONUTS page
↑ Zurawski SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J 12: 5113-9 PubMed GONUTS page
↑ Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
↑ Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page
↑ Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page
↑ Chae WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A 103: 9631-6 PubMed GONUTS page
↑ Sant'Angelo DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4: 367-76 PubMed GONUTS page
↑ Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page
↑ Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-12 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Schorle H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-4 PubMed GONUTS page
↑ Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page
↑ ^16.0 ^16.1 Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-51 PubMed GONUTS page
↑ Sadlack B et al. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-61 PubMed GONUTS page
↑ Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25: 2618-25 PubMed GONUTS page

[PMID:9184696-0] 1.0 ^1.1 Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page

[PMID:10485657-1] 2.0 ^2.1 ^2.2 ^2.3 Moriggl R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11: 225-30 PubMed GONUTS page

[PMID:12874832-2] 3.0 ^3.1 Butler JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J Cell Biochem 89: 975-91 PubMed GONUTS page

[PMID:1588041-3] 4.0 ^4.1 ^4.2 Casey LS et al. (1992) IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J Immunol 148: 3418-26 PubMed GONUTS page

[PMID:7584142-4] 5.0 ^5.1 Willerford DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-30 PubMed GONUTS page

[PMID:8262055-5] Zurawski SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J 12: 5113-9 PubMed GONUTS page

[PMID:10072077-6] Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page

[PMID:9492004-7] Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page

[PMID:11728336-8] Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page

[PMID:16769892-9] Chae WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A 103: 9631-6 PubMed GONUTS page

[PMID:8612131-10] Sant'Angelo DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4: 367-76 PubMed GONUTS page

[PMID:19139201-11] Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page

[PMID:7688139-12] Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-12 PubMed GONUTS page

[PMID:1830926-13] 14.0 ^14.1 ^14.2 ^14.3 Schorle H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-4 PubMed GONUTS page

[PMID:17213291-14] Wilson TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-93 PubMed GONUTS page

[PMID:16227984-15] 16.0 ^16.1 Fontenot JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-51 PubMed GONUTS page

[PMID:8402910-16] Sadlack B et al. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-61 PubMed GONUTS page

[PMID:7589135-17] Simpson SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25: 2618-25 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Il2 ( synonyms: IL-2 )
Protein Name(s)	interleukin 2,
External Links
MGI	MGI:96548

MGI:Il2

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