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MGI:Il1b

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Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Il1b ( synonyms: IL-1B, IL-1beta )
Protein Name(s) interleukin 1 beta,
External Links
MGI MGI:96543

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0000187

activation of MAPK activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0001660

fever generation

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0666

P

From MGI

GO:0001934

positive regulation of protein phosphorylation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0005125

cytokine activity

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O43645

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:2673020
PMID:12925700[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:3056874
PMID:15292196[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005125

cytokine activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

F

From MGI

GO:0005149

interleukin-1 receptor binding

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR003502
InterPro:IPR003294
InterPro:IPR003296

F

From MGI

GO:0005576

extracellular region

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

C

From MGI

GO:0005615

extracellular space

MGI:MGI:1929334
PMID:11016935[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:1930064
PMID:11168643[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:3580953
PMID:15905573[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:3640698
PMID:16423834[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

C

From MGI

GO:0005615

extracellular space

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

C

From MGI

GO:0006954

inflammatory response

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0006955

immune response

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR003502
InterPro:IPR003294
InterPro:IPR003296

P

From MGI

GO:0007204

elevation of cytosolic calcium ion concentration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0007568

aging

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0007613

memory

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0008083

growth factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR002348

F

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0010575

positive regulation vascular endothelial growth factor production

MGI:MGI:2652930
PMID:12598651[7]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0010575

positive regulation vascular endothelial growth factor production

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0010628

positive regulation of gene expression

MGI:MGI:4355633
PMID:19666510[8]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010829

negative regulation of glucose transport

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010977

negative regulation of neuron projection development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0014050

negative regulation of glutamate secretion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0019221

cytokine-mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

F

From MGI

GO:0030141

secretory granule

MGI:MGI:3640698
PMID:16423834[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030213

hyaluronan biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0030593

neutrophil chemotaxis

MGI:MGI:2673020
PMID:12925700[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030730

sequestering of triglyceride

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0031622

positive regulation of fever generation

MGI:MGI:4413614
PMID:19940926[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0031663

lipopolysaccharide-mediated signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0031982

vesicle

MGI:MGI:3580953
PMID:15905573[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0032308

positive regulation of prostaglandin secretion

MGI:MGI:4413614
PMID:19940926[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032496

response to lipopolysaccharide

MGI:MGI:3640698
PMID:16423834[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032496

response to lipopolysaccharide

MGI:MGI:3796019
PMID:18490713[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032496

response to lipopolysaccharide

MGI:MGI:3796019
PMID:18490713[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3606250

P

From MGI

GO:0032611

interleukin-1 beta production

MGI:MGI:3836373
PMID:19158679[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:96544
MGI:MGI:2686159
MGI:MGI:1931465

P

From MGI

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0032729

positive regulation of interferon-gamma production

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0032755

positive regulation of interleukin-6 production

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:O43645

P

From MGI

GO:0032755

positive regulation of interleukin-6 production

MGI:MGI:3056874
PMID:15292196[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032755

positive regulation of interleukin-6 production

MGI:MGI:4359971
PMID:19734906[13]

IDA: Inferred from Direct Assay

P

From MGI

GO:0032755

positive regulation of interleukin-6 production

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0032757

positive regulation of interleukin-8 production

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0032874

positive regulation of stress-activated MAPK cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0033198

response to ATP

MGI:MGI:3580953
PMID:15905573[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0033198

response to ATP

MGI:MGI:3713415
PMID:16301672[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0033198

response to ATP

MGI:MGI:3796019
PMID:18490713[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0033198

response to ATP

MGI:MGI:3796019
PMID:18490713[11]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3606250

P

From MGI

GO:0034116

positive regulation of heterotypic cell-cell adhesion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0035176

social behavior

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0035505

positive regulation of myosin light chain kinase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0035690

cellular response to drug

MGI:MGI:3836373
PMID:19158679[12]

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0042102

positive regulation of T cell proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0042221

response to chemical stimulus

MGI:MGI:3713415
PMID:16301672[14]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042346

positive regulation of NF-kappaB import into nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0043122

regulation of I-kappaB kinase/NF-kappaB cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

MGI:MGI:3607973
PMID:16260493[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

MGI:MGI:3607973
PMID:16260493[15]

IGI: Inferred from Genetic Interaction

MGI:MGI:1346877

P

From MGI

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0043407

negative regulation of MAP kinase activity

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043491

protein kinase B signaling cascade

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0043507

positive regulation of JUN kinase activity

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0045080

positive regulation of chemokine biosynthetic process

MGI:MGI:2673020
PMID:12925700[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045086

positive regulation of interleukin-2 biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0045410

positive regulation of interleukin-6 biosynthetic process

MGI:MGI:2673020
PMID:12925700[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045429

positive regulation of nitric oxide biosynthetic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0045665

negative regulation of neuron differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0045766

positive regulation of angiogenesis

MGI:MGI:2652930
PMID:12598651[7]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045833

negative regulation of lipid metabolic process

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045840

positive regulation of mitosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4355633
PMID:19666510[8]

IGI: Inferred from Genetic Interaction

MGI:MGI:1890474
MGI:MGI:96542

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4355633
PMID:19666510[8]

IGI: Inferred from Genetic Interaction

MGI:MGI:1932410
MGI:MGI:96542

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4355633
PMID:19666510[8]

IGI: Inferred from Genetic Interaction

MGI:MGI:96559
MGI:MGI:96542

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4359971
PMID:19734906[13]

IDA: Inferred from Direct Assay

P

From MGI

GO:0046330

positive regulation of JNK cascade

MGI:MGI:3607973
PMID:16260493[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0046330

positive regulation of JNK cascade

MGI:MGI:3607973
PMID:16260493[15]

IGI: Inferred from Genetic Interaction

MGI:MGI:1346877

P

From MGI

GO:0046330

positive regulation of JNK cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0046627

negative regulation of insulin receptor signaling pathway

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048711

positive regulation of astrocyte differentiation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0050796

regulation of insulin secretion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0050900

leukocyte migration

MGI:MGI:3036957
PMID:15034066[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050995

negative regulation of lipid catabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0050996

positive regulation of lipid catabolic process

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0051092

positive regulation of NF-kappaB transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0051781

positive regulation of cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0497

P

From MGI

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0070164

negative regulation of adiponectin secretion

MGI:MGI:3828398
PMID:16865359[9]

IDA: Inferred from Direct Assay

P

From MGI

GO:0070374

positive regulation of ERK1 and ERK2 cascade

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI

GO:0070487

monocyte aggregation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0071310

cellular response to organic substance

MGI:MGI:3836373
PMID:19158679[12]

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0071407

cellular response to organic cyclic compound

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P01584

P

From MGI

GO:2000178

negative regulation of neural precursor cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:Q63264

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 McLoughlin, RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112 598-607 PubMed GONUTS page
  2. 2.0 2.1 Lye, E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279 40653-8 PubMed GONUTS page
  3. Solle, M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276 125-32 PubMed GONUTS page
  4. Bune, AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102 103-13 PubMed GONUTS page
  5. 5.0 5.1 5.2 Bianco, F et al. (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J. Immunol. 174 7268-77 PubMed GONUTS page
  6. 6.0 6.1 6.2 Yao, C et al. (2006) Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. J. Biol. Chem. 281 7968-76 PubMed GONUTS page
  7. 7.0 7.1 Voronov, E et al. (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 2645-50 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Lagathu, C et al. (2006) Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 49 2162-73 PubMed GONUTS page
  10. 10.0 10.1 Hanada, R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462 505-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Pelegrin, P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J. Immunol. 180 7147-57 PubMed GONUTS page
  12. 12.0 12.1 12.2 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
  13. 13.0 13.1 Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page
  14. 14.0 14.1 Verhoef, PA et al. (2005) Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J. Immunol. 175 7623-34 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page
  16. Young, RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J. Immunol. 172 4493-502 PubMed GONUTS page
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