MGI:Il1b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0001660	fever generation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0666	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:O43645	F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:3056874 PMID:15292196^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	F	From MGI
	GO:0005149	interleukin-1 receptor binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003502 InterPro:IPR003294 InterPro:IPR003296	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003294 InterPro:IPR003296	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1929334 PMID:11016935^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1930064 PMID:11168643^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3580953 PMID:15905573^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3640698 PMID:16423834^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	C	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0006955	immune response	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003502 InterPro:IPR003294 InterPro:IPR003296	P	From MGI
	GO:0007204	elevation of cytosolic calcium ion concentration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0007568	aging	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0007613	memory	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR002348	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0010575	positive regulation vascular endothelial growth factor production	MGI:MGI:2652930 PMID:12598651^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010575	positive regulation vascular endothelial growth factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4355633 PMID:19666510^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010829	negative regulation of glucose transport	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010977	negative regulation of neuron projection development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0014050	negative regulation of glutamate secretion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	F	From MGI
	GO:0030141	secretory granule	MGI:MGI:3640698 PMID:16423834^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030213	hyaluronan biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0030593	neutrophil chemotaxis	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030730	sequestering of triglyceride	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0031622	positive regulation of fever generation	MGI:MGI:4413614 PMID:19940926^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0031982	vesicle	MGI:MGI:3580953 PMID:15905573^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0032308	positive regulation of prostaglandin secretion	MGI:MGI:4413614 PMID:19940926^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3640698 PMID:16423834^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3796019 PMID:18490713^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032496	response to lipopolysaccharide	MGI:MGI:3796019 PMID:18490713^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3606250	P	From MGI
	GO:0032611	interleukin-1 beta production	MGI:MGI:3836373 PMID:19158679^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:96544 MGI:MGI:2686159 MGI:MGI:1931465	P	From MGI
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:O43645	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:3056874 PMID:15292196^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:4359971 PMID:19734906^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0032757	positive regulation of interleukin-8 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0032874	positive regulation of stress-activated MAPK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0033198	response to ATP	MGI:MGI:3580953 PMID:15905573^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033198	response to ATP	MGI:MGI:3713415 PMID:16301672^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033198	response to ATP	MGI:MGI:3796019 PMID:18490713^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033198	response to ATP	MGI:MGI:3796019 PMID:18490713^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3606250	P	From MGI
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0035176	social behavior	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0035505	positive regulation of myosin light chain kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0035690	cellular response to drug	MGI:MGI:3836373 PMID:19158679^[12]	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0042221	response to chemical stimulus	MGI:MGI:3713415 PMID:16301672^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042346	positive regulation of NF-kappaB import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3607973 PMID:16260493^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3607973 PMID:16260493^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0043407	negative regulation of MAP kinase activity	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043491	protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0043507	positive regulation of JUN kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0045080	positive regulation of chemokine biosynthetic process	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045086	positive regulation of interleukin-2 biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0045410	positive regulation of interleukin-6 biosynthetic process	MGI:MGI:2673020 PMID:12925700^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045429	positive regulation of nitric oxide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0045665	negative regulation of neuron differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:2652930 PMID:12598651^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045833	negative regulation of lipid metabolic process	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4355633 PMID:19666510^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1890474 MGI:MGI:96542	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4355633 PMID:19666510^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1932410 MGI:MGI:96542	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4355633 PMID:19666510^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:96559 MGI:MGI:96542	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4359971 PMID:19734906^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3607973 PMID:16260493^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3607973 PMID:16260493^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0046627	negative regulation of insulin receptor signaling pathway	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048711	positive regulation of astrocyte differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0050900	leukocyte migration	MGI:MGI:3036957 PMID:15034066^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050995	negative regulation of lipid catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0050996	positive regulation of lipid catabolic process	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	From MGI
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0070164	negative regulation of adiponectin secretion	MGI:MGI:3828398 PMID:16865359^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
	GO:0070487	monocyte aggregation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0071310	cellular response to organic substance	MGI:MGI:3836373 PMID:19158679^[12]	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01584	P	From MGI
	GO:2000178	negative regulation of neural precursor cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63264	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 McLoughlin RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112: 598-607 PubMed GONUTS page
↑ ^2.0 ^2.1 Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page
↑ Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-32 PubMed GONUTS page
↑ Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Bianco F et al. (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 174: 7268-77 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yao C et al. (2006) Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. J Biol Chem 281: 7968-76 PubMed GONUTS page
↑ ^7.0 ^7.1 Voronov E et al. (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 100: 2645-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lagathu C et al. (2006) Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 49: 2162-73 PubMed GONUTS page
↑ ^10.0 ^10.1 Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Pelegrin P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180: 7147-57 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Bürckstümmer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-72 PubMed GONUTS page
↑ ^13.0 ^13.1 Chang M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10: 1089-95 PubMed GONUTS page
↑ ^14.0 ^14.1 Verhoef PA et al. (2005) Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol 175: 7623-34 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Shim JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-81 PubMed GONUTS page
↑ Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page

[PMID:12925700-0] 1.0 ^1.1 ^1.2 ^1.3 McLoughlin RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112: 598-607 PubMed GONUTS page

[PMID:15292196-1] 2.0 ^2.1 Lye E et al. (2004) The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J Biol Chem 279: 40653-8 PubMed GONUTS page

[PMID:11016935-2] Solle M et al. (2001) Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-32 PubMed GONUTS page

[PMID:11168643-3] Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page

[PMID:15905573-4] 5.0 ^5.1 ^5.2 Bianco F et al. (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol 174: 7268-77 PubMed GONUTS page

[PMID:16423834-5] 6.0 ^6.1 ^6.2 Yao C et al. (2006) Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. J Biol Chem 281: 7968-76 PubMed GONUTS page

[PMID:12598651-6] 7.0 ^7.1 Voronov E et al. (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 100: 2645-50 PubMed GONUTS page

[PMID:19666510-7] 8.0 ^8.1 ^8.2 ^8.3 Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page

[PMID:16865359-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lagathu C et al. (2006) Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 49: 2162-73 PubMed GONUTS page

[PMID:19940926-9] 10.0 ^10.1 Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page

[PMID:18490713-10] 11.0 ^11.1 ^11.2 ^11.3 Pelegrin P et al. (2008) P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol 180: 7147-57 PubMed GONUTS page

[PMID:19158679-11] 12.0 ^12.1 ^12.2 Bürckstümmer T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10: 266-72 PubMed GONUTS page

[PMID:19734906-12] 13.0 ^13.1 Chang M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10: 1089-95 PubMed GONUTS page

[PMID:16301672-13] 14.0 ^14.1 Verhoef PA et al. (2005) Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol 175: 7623-34 PubMed GONUTS page

[PMID:16260493-14] 15.0 ^15.1 ^15.2 ^15.3 Shim JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-81 PubMed GONUTS page

[PMID:15034066-15] Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Il1b ( synonyms: IL-1B, IL-1beta )
Protein Name(s)	interleukin 1 beta,
External Links
MGI	MGI:96543

MGI:Il1b

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