MGI:Il18

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3688048 PMID:11466388^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q14116	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2176422 PMID:11894098^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3050756 PMID:15220916^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3686795 PMID:16949315^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	C	From MGI
	GO:0006954	inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0006955	immune response	MGI:MGI:2178014 PMID:12048345^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0008625	induction of apoptosis via death domain receptors	MGI:MGI:3688022 PMID:11714750^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4355633 PMID:19666510^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	C	From MGI
	GO:0030155	regulation of cell adhesion	MGI:MGI:3688046 PMID:11477102^[8]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q14116	P	From MGI
	GO:0030155	regulation of cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0030431	sleep	MGI:MGI:3688052 PMID:11506998^[9]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P97636	P	From MGI
	GO:0030431	sleep	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0032722	positive regulation of chemokine production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:2176422 PMID:11894098^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:2176424 PMID:11894097^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0032757	positive regulation of interleukin-8 production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0032819	positive regulation of natural killer cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0032930	positive regulation of superoxide anion generation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0042088	T-helper 1 type immune response	MGI:MGI:3690805 PMID:8766574^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q14116	P	From MGI
	GO:0042088	T-helper 1 type immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0042095	interferon-gamma biosynthetic process	MGI:MGI:3687928 PMID:11907086^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:3690805 PMID:8766574^[11]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q14116	P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0042231	interleukin-13 biosynthetic process	MGI:MGI:3688021 PMID:11716531^[13]	TAS: Traceable Author Statement		P	From MGI
	GO:0043117	positive regulation of vascular permeability	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0051142	positive regulation of NK T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:0071375	cellular response to peptide hormone stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q14116	P	From MGI
	GO:2000256	positive regulation of male germ cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
	GO:2000504	positive regulation of blood vessel remodeling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P97636	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Park CC et al. (2001) Evidence of IL-18 as a novel angiogenic mediator. J Immunol 167: 1644-53 PubMed GONUTS page
↑ ^2.0 ^2.1 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page
↑ Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
↑ Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page
↑ Kashiwamura S et al. (2002) Roles of interleukin-18 in tissue destruction and compensatory reactions. J Immunother 25 Suppl 1: S4-11 PubMed GONUTS page
↑ Reddy P et al. (2001) Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med 194: 1433-40 PubMed GONUTS page
↑ Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page
↑ Morel JC et al. (2001) A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J Biol Chem 276: 37069-75 PubMed GONUTS page
↑ Kubota T et al. (2001) Interleukin-18 promotes sleep in rabbits and rats. Am J Physiol Regul Integr Comp Physiol 281: R828-38 PubMed GONUTS page
↑ Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page
↑ ^11.0 ^11.1 Micallef MJ et al. (1996) Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 26: 1647-51 PubMed GONUTS page
↑ Wang B et al. (2002) Contribution of Langerhans cell-derived IL-18 to contact hypersensitivity. J Immunol 168: 3303-8 PubMed GONUTS page
↑ Chakir H et al. (2001) Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18. Cell Immunol 212: 71-81 PubMed GONUTS page

[PMID:11466388-0] Park CC et al. (2001) Evidence of IL-18 as a novel angiogenic mediator. J Immunol 167: 1644-53 PubMed GONUTS page

[PMID:11894098-1] 2.0 ^2.1 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page

[PMID:15220916-2] Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page

[PMID:16949315-3] Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page

[PMID:12048345-4] Kashiwamura S et al. (2002) Roles of interleukin-18 in tissue destruction and compensatory reactions. J Immunother 25 Suppl 1: S4-11 PubMed GONUTS page

[PMID:11714750-5] Reddy P et al. (2001) Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. J Exp Med 194: 1433-40 PubMed GONUTS page

[PMID:19666510-6] Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 106: 13463-8 PubMed GONUTS page

[PMID:11477102-7] Morel JC et al. (2001) A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J Biol Chem 276: 37069-75 PubMed GONUTS page

[PMID:11506998-8] Kubota T et al. (2001) Interleukin-18 promotes sleep in rabbits and rats. Am J Physiol Regul Integr Comp Physiol 281: R828-38 PubMed GONUTS page

[PMID:11894097-9] Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page

[PMID:8766574-10] 11.0 ^11.1 Micallef MJ et al. (1996) Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 26: 1647-51 PubMed GONUTS page

[PMID:11907086-11] Wang B et al. (2002) Contribution of Langerhans cell-derived IL-18 to contact hypersensitivity. J Immunol 168: 3303-8 PubMed GONUTS page

[PMID:11716531-12] Chakir H et al. (2001) Cytokine expression by murine DX5+ cells in response to IL-12, IL-18, or the combination of IL-12 and IL-18. Cell Immunol 212: 71-81 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Il18 ( synonyms: Igif, Il-18 )
Protein Name(s)	interleukin 18,
External Links
MGI	MGI:107936

MGI:Il18

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