MGI:Il12b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001916	positive regulation of T cell mediated cytotoxicity	MGI:MGI:3027369 PMID:14688363^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002230	positive regulation of defense response to virus by host	MGI:MGI:3027369 PMID:14688363^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002230	positive regulation of defense response to virus by host	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0002323	natural killer cell activation involved in immune response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	P	From MGI
	GO:0002827	positive regulation of T-helper 1 type immune response	MGI:MGI:3027369 PMID:14688363^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002827	positive regulation of T-helper 1 type immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	MGI:MGI:3686795 PMID:16949315^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004896	cytokine receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003530	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1927676 PMID:11114383^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9EQ14	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2667551 PMID:12871593^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2669022 PMID:12855817^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3050756 PMID:15220916^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3051177 PMID:15240714^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3528786 PMID:15692051^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3608246 PMID:16236719^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3653161 PMID:9348310^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3829555 PMID:17277142^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:63529 PMID:7690439^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2155044 PMID:11737071^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:2667551 PMID:12871593^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010224	response to UV-B	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0010535	positive regulation of activation of JAK2 kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003530	C	From MGI
	GO:0016477	cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0019221	cytokine-mediated signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003530	P	From MGI
	GO:0019233	sensory perception of pain	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	P	From MGI
	GO:0030101	natural killer cell activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032693	negative regulation of interleukin-10 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032700	negative regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:3653161 PMID:9348310^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:96539	P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:3686795 PMID:16949315^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032733	positive regulation of interleukin-10 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032735	positive regulation of interleukin-12 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032760	positive regulation of tumor necrosis factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032816	positive regulation of natural killer cell activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0032819	positive regulation of natural killer cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0034393	positive regulation of smooth muscle cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042093	T-helper cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:1926579 PMID:11057672^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042102	positive regulation of T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042164	interleukin-12 alpha subunit binding	MGI:MGI:3050756 PMID:15220916^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P43431	F	From MGI
	GO:0042164	interleukin-12 alpha subunit binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	F	From MGI
	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	F	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:2667551 PMID:12871593^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0042832	defense response to protozoan	MGI:MGI:3653161 PMID:9348310^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:96539	P	From MGI
	GO:0042832	defense response to protozoan	MGI:MGI:3653161 PMID:9348310^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857201	P	From MGI
	GO:0043514	interleukin-12 complex	MGI:MGI:3050756 PMID:15220916^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043514	interleukin-12 complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	C	From MGI
	GO:0043514	interleukin-12 complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	C	From MGI
	GO:0043514	interleukin-12 complex	MGI:MGI:63529 PMID:7690439^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:96539	C	From MGI
	GO:0044130	negative regulation of growth of symbiont in host	MGI:MGI:3653161 PMID:9348310^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857201	P	From MGI
	GO:0045672	positive regulation of osteoclast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0045785	positive regulation of cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q62712	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	F	From MGI
	GO:0048662	negative regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0050671	positive regulation of lymphocyte proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0050829	defense response to Gram-negative bacterium	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0051135	positive regulation of NK T cell activation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0051142	positive regulation of NK T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	P	From MGI
	GO:0051607	defense response to virus	MGI:MGI:3829555 PMID:17277142^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070743	interleukin-23 complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P29460	C	From MGI
	GO:0071222	cellular response to lipopolysaccharide	MGI:MGI:4412460 PMID:18025219^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071346	cellular response to interferon-gamma	MGI:MGI:4412460 PMID:18025219^[15]	IDA: Inferred from Direct Assay		P	From MGI
contributes_to	GO:0005125	cytokine activity	MGI:MGI:1926579 PMID:11057672^[14]	IDA: Inferred from Direct Assay		F	From MGI
contributes_to	GO:0005126	cytokine receptor binding	MGI:MGI:1927676 PMID:11114383^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q60837	F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Ha SJ et al. (2004) IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol 172: 525-31 PubMed GONUTS page
↑ ^2.0 ^2.1 Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page
↑ ^3.0 ^3.1 Oppmann B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Jana M et al. (2003) Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. J Neurochem 86: 519-28 PubMed GONUTS page
↑ Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
↑ McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
↑ Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page
↑ Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Scharton-Kersten T et al. (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186: 1523-34 PubMed GONUTS page
↑ ^11.0 ^11.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Ploemacher RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7: 1374-80 PubMed GONUTS page
↑ Zourbas S et al. (2001) Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy. Clin Exp Immunol 126: 519-28 PubMed GONUTS page
↑ ^14.0 ^14.1 Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916-20 PubMed GONUTS page
↑ ^15.0 ^15.1 Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179: 7729-40 PubMed GONUTS page

[PMID:14688363-0] 1.0 ^1.1 ^1.2 Ha SJ et al. (2004) IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization. J Immunol 172: 525-31 PubMed GONUTS page

[PMID:16949315-1] 2.0 ^2.1 Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page

[PMID:11114383-2] 3.0 ^3.1 Oppmann B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-25 PubMed GONUTS page

[PMID:12871593-3] 4.0 ^4.1 ^4.2 Jana M et al. (2003) Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. J Neurochem 86: 519-28 PubMed GONUTS page

[PMID:12855817-4] Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:15220916-5] 6.0 ^6.1 ^6.2 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page

[PMID:15240714-6] McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page

[PMID:15692051-7] Kobayashi KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-4 PubMed GONUTS page

[PMID:16236719-8] Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page

[PMID:9348310-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Scharton-Kersten T et al. (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med 186: 1523-34 PubMed GONUTS page

[PMID:17277142-10] 11.0 ^11.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page

[PMID:7690439-11] 12.0 ^12.1 Ploemacher RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7: 1374-80 PubMed GONUTS page

[PMID:11737071-12] Zourbas S et al. (2001) Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy. Clin Exp Immunol 126: 519-28 PubMed GONUTS page

[PMID:11057672-13] 14.0 ^14.1 Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916-20 PubMed GONUTS page

[PMID:18025219-14] 15.0 ^15.1 Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179: 7729-40 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Il12b ( synonyms: IL-12 p40, Il-12b, Il-12p40, IL-23 subunit p40 )
Protein Name(s)	interleukin 12b,
External Links
MGI	MGI:96540

MGI:Il12b

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