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MGI:Il10
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Il10 ( synonyms: cytokine synthesis inhibitory factor, IL-10 ) | |
| Protein Name(s) | interleukin 10, | |
| External Links | ||
| MGI | MGI:96537 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001818 |
negative regulation of cytokine production |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002237 |
response to molecule of bacterial origin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002740 |
negative regulation of cytokine secretion involved in immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002875 |
negative regulation of chronic inflammatory response to antigenic stimulus |
MGI:MGI:3774790 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0002904 |
positive regulation of B cell apoptotic process |
MGI:MGI:892164 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3033882 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:3051177 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
F |
From MGI |
||
| GO:0005141 |
interleukin-10 receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:1347429 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:1861065 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3050756 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3051177 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3686795 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3694583 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3695768 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3839525 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3817792 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006954 |
inflammatory response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010468 |
regulation of gene expression |
MGI:MGI:892164 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030886 |
negative regulation of myeloid dendritic cell activation |
MGI:MGI:3051177 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0030889 |
negative regulation of B cell proliferation |
MGI:MGI:892164 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032689 |
negative regulation of interferon-gamma production |
MGI:MGI:3774790 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0032695 |
negative regulation of interleukin-12 production |
MGI:MGI:3051177 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0032715 |
negative regulation of interleukin-6 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
MGI:MGI:3774790 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0032800 |
receptor biosynthetic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042536 |
negative regulation of tumor necrosis factor biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042742 |
defense response to bacterium |
MGI:MGI:1861065 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044130 |
negative regulation of growth of symbiont in host |
MGI:MGI:3774790 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
||
| GO:0045019 |
negative regulation of nitric oxide biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045348 |
positive regulation of MHC class II biosynthetic process |
MGI:MGI:3033882 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3044839 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050715 |
positive regulation of cytokine secretion |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051045 |
negative regulation of membrane protein ectodomain proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051384 |
response to glucocorticoid stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051930 |
regulation of sensory perception of pain |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060670 |
branching involved in embryonic placenta morphogenesis |
MGI:MGI:3664708 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857199 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gjertsson I et al. (2002) Interleukin-10 ameliorates the outcome of Staphylococcus aureus arthritis by promoting bacterial clearance. Clin Exp Immunol 130: 409-14 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Li L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell Immunol 178: 33-41 PubMed GONUTS page
- ↑ 3.0 3.1 Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer 83: 1192-201 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
- ↑ Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18: 5943-52 PubMed GONUTS page
- ↑ 6.0 6.1 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page
- ↑ Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
- ↑ Watanabe T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25: 473-85 PubMed GONUTS page
- ↑ Kamanaka M et al. (2006) Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 25: 941-52 PubMed GONUTS page
- ↑ Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page
- ↑ Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 77: 1376-82 PubMed GONUTS page
- ↑ van Hamburg JP et al. (2008) Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol 38: 2573-86 PubMed GONUTS page
- ↑ Pauleau AL et al. (2004) Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol 172: 7565-73 PubMed GONUTS page
- ↑ Roberts CT et al. (2003) Altered placental development in interleukin-10 null mutant mice. Placenta 24 Suppl A: S94-9 PubMed GONUTS page
