GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Ikzf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ikzf1 ( synonyms: Ikaros, LyF-1, Zfpn1a1 ) | |
| Protein Name(s) | IKAROS family zinc finger 1, | |
| External Links | ||
| MGI | MGI:1342540 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2652944 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001779 |
natural killer cell differentiation |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2157261 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3575374 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:69548 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:69548 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1333986 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3575864 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q6PDQ2 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:2652944 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3617295 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:69548 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:2157261 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005721 |
centromeric heterochromatin |
MGI:MGI:3575864 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2157261 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0030097 |
hemopoiesis |
MGI:MGI:2157261 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0030183 |
B cell differentiation |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0030217 |
T cell differentiation |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:3575374 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0030900 |
forebrain development |
MGI:MGI:3617295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:3617295 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95707 |
P |
From MGI |
||
| GO:0040018 |
positive regulation of multicellular organism growth |
MGI:MGI:3617295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
F |
From MGI |
||
| GO:0045660 |
positive regulation of neutrophil differentiation |
MGI:MGI:2654310 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2667175 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3575864 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:69548 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3575374 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3617295 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1203354 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:1333610 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0048535 |
lymph node development |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0048541 |
Peyer's patch development |
MGI:MGI:68746 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158738 |
P |
From MGI |
||
| GO:0048732 |
gland development |
MGI:MGI:3617295 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0051138 |
positive regulation of NK T cell differentiation |
MGI:MGI:1340364 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
||
| GO:0060041 |
retina development in camera-type eye |
MGI:MGI:3831471 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2158690 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ström L et al. (2003) Binding of Ikaros to germline Ig heavy chain gamma1 and epsilon promoters. Mol Immunol 39: 771-82 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Georgopoulos K et al. (1994) The Ikaros gene is required for the development of all lymphoid lineages. Cell 79: 143-56 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lopez RA et al. (2002) Multiple hematopoietic defects and delayed globin switching in Ikaros null mice. Proc Natl Acad Sci U S A 99: 602-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ezzat S et al. (2005) Ikaros integrates endocrine and immune system development. J Clin Invest 115: 1021-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Molnár A & Georgopoulos K (1994) The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 14: 8292-303 PubMed GONUTS page
- ↑ Kim J et al. (1999) Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10: 345-55 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Gómez-del Arco P et al. (2005) Ikaros SUMOylation: switching out of repression. Mol Cell Biol 25: 2688-97 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Ezzat S et al. (2006) An essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth. Proc Natl Acad Sci U S A 103: 2214-9 PubMed GONUTS page
- ↑ Dumortier A et al. (2003) Ikaros regulates neutrophil differentiation. Blood 101: 2219-26 PubMed GONUTS page
- ↑ Kelley CM et al. (1998) Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol 8: 508-15 PubMed GONUTS page
- ↑ Honma Y et al. (1999) Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett 447: 76-80 PubMed GONUTS page
- ↑ Boggs SS et al. (1998) Lack of natural killer cell precursors in fetal liver of Ikaros knockout mutant mice. Nat Immun 16: 137-45 PubMed GONUTS page
- ↑ Elliott J et al. (2008) Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron 60: 26-39 PubMed GONUTS page
