MGI:Ihh

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001501	skeletal system development	MGI:MGI:3608181 PMID:16278811^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3609381 MGI:MGI:2176264	P	From MGI
	GO:0001503	ossification	MGI:MGI:2154465 PMID:11748145^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001569	patterning of blood vessels	MGI:MGI:3574706 PMID:15689378^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001649	osteoblast differentiation	MGI:MGI:3036410 PMID:14973297^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:3766861 PMID:17881493^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001708	cell fate specification	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001763	morphogenesis of a branching structure	MGI:MGI:1926239 PMID:11044404^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001944	vasculature development	MGI:MGI:3766861 PMID:17881493^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0001947	heart looping	MGI:MGI:5142377 PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002053	positive regulation of mesenchymal cell proliferation	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0003382	epithelial cell morphogenesis	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0003406	retinal pigment epithelium development	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0005113	patched binding	MGI:MGI:1313055 PMID:9811851^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q13635 UniProtKB:Q9Y6C5	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1333378 PMID:10050855^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WU59	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1003	C	From MGI
	GO:0006029	proteoglycan metabolic process	MGI:MGI:4999722 PMID:16935278^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:88177 MGI:MGI:88177	P	From MGI
	GO:0006508	proteolysis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0645	P	From MGI
	GO:0006508	proteolysis	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001767	P	From MGI
	GO:0007154	cell communication	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001657	P	From MGI
	GO:0007224	smoothened signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0007224	smoothened signaling pathway	MGI:MGI:4430672 PMID:19590577^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:104903	P	From MGI
	GO:0007267	cell-cell signaling	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000320	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001657 InterPro:IPR000320	P	From MGI
	GO:0007389	pattern specification process	MGI:MGI:1277795 PMID:9671585^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857644	P	From MGI
	GO:0008233	peptidase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0645	F	From MGI
	GO:0008233	peptidase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001767	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3608261 PMID:16284117^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3695832 PMID:17191253^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3695832 PMID:17191253^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0009790	embryo development	MGI:MGI:3766861 PMID:17881493^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0009880	embryonic pattern specification	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0009968	negative regulation of signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016539	intein-mediated protein splicing	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006141	P	From MGI
	GO:0016787	hydrolase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	F	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3583389 PMID:15951842^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030704	vitelline membrane formation	MGI:MGI:3766861 PMID:17881493^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0031012	extracellular matrix	MGI:MGI:2149274 PMID:11476578^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0031016	pancreas development	MGI:MGI:1858523 PMID:10821773^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0031016	pancreas development	MGI:MGI:1926239 PMID:11044404^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:98297	P	From MGI
	GO:0032332	positive regulation of chondrocyte differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:1335697 PMID:10208865^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033085	negative regulation of T cell differentiation in thymus	MGI:MGI:3836494 PMID:19109233^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033088	negative regulation of immature T cell proliferation in thymus	MGI:MGI:3836494 PMID:19109233^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033089	positive regulation of T cell differentiation in thymus	MGI:MGI:3836494 PMID:19109233^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035264	multicellular organism growth	MGI:MGI:1858523 PMID:10821773^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0035988	chondrocyte proliferation	MGI:MGI:4999722 PMID:16935278^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0040008	regulation of growth	MGI:MGI:4430672 PMID:19590577^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:104903	P	From MGI
	GO:0043010	camera-type eye development	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0045453	bone resorption	MGI:MGI:1335697 PMID:10208865^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045595	regulation of cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0045596	negative regulation of cell differentiation	MGI:MGI:3608261 PMID:16284117^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0045880	positive regulation of smoothened signaling pathway	MGI:MGI:5142377 PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3766861 PMID:17881493^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:98297	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0046638	positive regulation of alpha-beta T cell differentiation	MGI:MGI:3836494 PMID:19109233^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046639	negative regulation of alpha-beta T cell differentiation	MGI:MGI:3836494 PMID:19109233^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048074	negative regulation of eye pigmentation	MGI:MGI:3807630 PMID:17464332^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0048469	cell maturation	MGI:MGI:3511731 PMID:15576404^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0048557	embryonic digestive tract morphogenesis	MGI:MGI:1858523 PMID:10821773^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0048596	embryonic camera-type eye morphogenesis	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0048666	neuron development	MGI:MGI:1858523 PMID:10821773^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0048745	smooth muscle tissue development	MGI:MGI:1858523 PMID:10821773^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445836	P	From MGI
	GO:0051216	cartilage development	MGI:MGI:3695832 PMID:17191253^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0060220	camera-type eye photoreceptor cell fate commitment	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0060323	head morphogenesis	MGI:MGI:4999722 PMID:16935278^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0061053	somite development	MGI:MGI:5142377 PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072498	embryonic skeletal joint development	MGI:MGI:3695832 PMID:17191253^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
	GO:0090136	epithelial cell-cell adhesion	MGI:MGI:3807419 PMID:18582859^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934258	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Razzaque MS et al. (2005) Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol 207: 453-61 PubMed GONUTS page
↑ Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-108 PubMed GONUTS page
↑ Colnot C et al. (2005) Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132: 1057-67 PubMed GONUTS page
↑ Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-18 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 320: 242-55 PubMed GONUTS page
↑ ^7.0 ^7.1 Hebrok M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127: 4905-13 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page
↑ Carpenter D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A 95: 13630-4 PubMed GONUTS page
↑ Chuang PT & McMahon AP (1999) Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-21 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Young B et al. (2006) Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol 299: 272-82 PubMed GONUTS page
↑ ^12.0 ^12.1 Capurro MI et al. (2009) Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep 10: 901-7 PubMed GONUTS page
↑ Yang Y et al. (1998) Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. Development 125: 3123-32 PubMed GONUTS page
↑ ^14.0 ^14.1 Koziel L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132: 5249-60 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Shibukawa Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236: 426-34 PubMed GONUTS page
↑ Kobayashi T et al. (2005) Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest 115: 1734-42 PubMed GONUTS page
↑ Gritli-Linde A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol 236: 364-86 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Ramalho-Santos M et al. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127: 2763-72 PubMed GONUTS page
↑ ^19.0 ^19.1 Akiyama H et al. (1999) Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs. Biochem Biophys Res Commun 257: 814-20 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Outram SV et al. (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood 113: 2217-28 PubMed GONUTS page
↑ Jacobs SB et al. (2007) Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ 14: 1374-85 PubMed GONUTS page
↑ Hu H et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132: 49-60 PubMed GONUTS page

[PMID:16278811-0] Razzaque MS et al. (2005) Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol 207: 453-61 PubMed GONUTS page

[PMID:11748145-1] Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-108 PubMed GONUTS page

[PMID:15689378-2] Colnot C et al. (2005) Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132: 1057-67 PubMed GONUTS page

[PMID:14973297-3] Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-18 PubMed GONUTS page

[PMID:17881493-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page

[PMID:18582859-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 320: 242-55 PubMed GONUTS page

[PMID:11044404-6] 7.0 ^7.1 Hebrok M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127: 4905-13 PubMed GONUTS page

[PMID:11517919-7] 8.0 ^8.1 ^8.2 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page

[PMID:9811851-8] Carpenter D et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A 95: 13630-4 PubMed GONUTS page

[PMID:10050855-9] Chuang PT & McMahon AP (1999) Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-21 PubMed GONUTS page

[PMID:16935278-10] 11.0 ^11.1 ^11.2 Young B et al. (2006) Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol 299: 272-82 PubMed GONUTS page

[PMID:19590577-11] 12.0 ^12.1 Capurro MI et al. (2009) Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep 10: 901-7 PubMed GONUTS page

[PMID:9671585-12] Yang Y et al. (1998) Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. Development 125: 3123-32 PubMed GONUTS page

[PMID:16284117-13] 14.0 ^14.1 Koziel L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132: 5249-60 PubMed GONUTS page

[PMID:17191253-14] 15.0 ^15.1 ^15.2 ^15.3 Shibukawa Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev Dyn 236: 426-34 PubMed GONUTS page

[PMID:15951842-15] Kobayashi T et al. (2005) Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest 115: 1734-42 PubMed GONUTS page

[PMID:11476578-16] Gritli-Linde A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol 236: 364-86 PubMed GONUTS page

[PMID:10821773-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Ramalho-Santos M et al. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127: 2763-72 PubMed GONUTS page

[PMID:10208865-18] 19.0 ^19.1 Akiyama H et al. (1999) Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs. Biochem Biophys Res Commun 257: 814-20 PubMed GONUTS page

[PMID:19109233-19] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Outram SV et al. (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood 113: 2217-28 PubMed GONUTS page

[PMID:17464332-20] Jacobs SB et al. (2007) Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ 14: 1374-85 PubMed GONUTS page

[PMID:15576404-21] Hu H et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132: 49-60 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Ihh
Protein Name(s)	Indian hedgehog,
External Links
MGI	MGI:96533

MGI:Ihh

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