Ambox notice.png

GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.

You can help reduce stress on the server by:

  1. not reloading pages frequently - this just adds
  2. opening links in new windows (so you can read the old page)

MGI:Ighm

From GONUTS
Jump to: navigation, search

Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ighm ( synonyms: Ig mu, Igh-M, Igh6, IgM, muH )
Protein Name(s) immunoglobulin heavy constant mu,
External Links
MGI MGI:96448

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000187

activation of MAPK activity

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000187

activation of MAPK activity

MGI:MGI:79455
PMID:8626447[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002455

humoral immune response mediated by circulating immunoglobulin

MGI:MGI:3037416
PMID:14988498[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002455

humoral immune response mediated by circulating immunoglobulin

MGI:MGI:67606
PMID:8041705[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002455

humoral immune response mediated by circulating immunoglobulin

MGI:MGI:77753
PMID:8566034[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0003823

antigen binding

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:1889050
PMID:8418208[7]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:2670820
PMID:12882831[8]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:3037416
PMID:14988498[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:62368
PMID:7688139[9]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:67606
PMID:8041705[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:67723
PMID:8047141[10]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:77753
PMID:8566034[5]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003823

antigen binding

MGI:MGI:78617
PMID:8552190[11]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004888

transmembrane signaling receptor activity

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:3521842
PMID:1373499[12]

IPI: Inferred from Physical Interaction

UniProtKB:P01843

F

From MGI

GO:0005615

extracellular space

MGI:MGI:3718932
PMID:17658279[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1332382
PMID:10072077[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1889050
PMID:8418208[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:1889695
PMID:10979977[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:2670820
PMID:12882831[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3028699
PMID:14662849[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3036943
PMID:14557413[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3581459
PMID:15909309[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:3764742
PMID:17941951[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:67606
PMID:8041705[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77314
PMID:7477352[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77315
PMID:7477353[21]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:77753
PMID:8566034[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:79455
PMID:8626447[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0009897

external side of plasma membrane

MGI:MGI:80946
PMID:8666928[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016064

immunoglobulin mediated immune response

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016064

immunoglobulin mediated immune response

MGI:MGI:1889050
PMID:8418208[7]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016064

immunoglobulin mediated immune response

MGI:MGI:67723
PMID:8047141[10]

IDA: Inferred from Direct Assay

P

From MGI

GO:0016064

immunoglobulin mediated immune response

MGI:MGI:78617
PMID:8552190[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:1889050
PMID:8418208[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:2670820
PMID:12882831[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:3028699
PMID:14662849[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:3036943
PMID:14557413[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:77314
PMID:7477352[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:78617
PMID:8552190[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019815

B cell receptor complex

MGI:MGI:79455
PMID:8626447[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019882

antigen processing and presentation

MGI:MGI:3033879
PMID:11854359[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:1889695
PMID:10979977[15]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:3051152
PMID:15240667[24]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:3619310
PMID:14607964[25]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:78617
PMID:8552190[11]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030890

positive regulation of B cell proliferation

MGI:MGI:80946
PMID:8666928[22]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:1889050
PMID:8418208[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:1926579
PMID:11057672[26]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:2670820
PMID:12882831[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:2671681
PMID:9492004[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:3037416
PMID:14988498[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:3039643
PMID:12867038[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:62368
PMID:7688139[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:67606
PMID:8041705[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:67723
PMID:8047141[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:77753
PMID:8566034[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0042571

immunoglobulin complex, circulating

MGI:MGI:78617
PMID:8552190[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043410

positive regulation of MAPK cascade

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045022

early endosome to late endosome transport

MGI:MGI:3033879
PMID:11854359[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045807

positive regulation of endocytosis

MGI:MGI:3033879
PMID:11854359[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048471

perinuclear region of cytoplasm

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:77358
PMID:7499277[29]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:79455
PMID:8626447[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050829

defense response to Gram-negative bacterium

MGI:MGI:2683356
PMID:14688352[30]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857187

P

From MGI

GO:0050853

B cell receptor signaling pathway

MGI:MGI:1095647
PMID:9254656[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050853

B cell receptor signaling pathway

MGI:MGI:3521842
PMID:1373499[12]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050853

B cell receptor signaling pathway

MGI:MGI:77358
PMID:7499277[29]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050853

B cell receptor signaling pathway

MGI:MGI:79455
PMID:8626447[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050871

positive regulation of B cell activation

MGI:MGI:1354084
PMID:10704460[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050871

positive regulation of B cell activation

MGI:MGI:3033879
PMID:11854359[23]

IDA: Inferred from Direct Assay

P

From MGI

GO:0050871

positive regulation of B cell activation

MGI:MGI:77753
PMID:8566034[5]

IDA: Inferred from Direct Assay

P

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Pani G et al. (1997) The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med 186: 581-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem 271: 6458-66 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Castigli E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A 101: 3903-8 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Fujiwara H et al. (1994) The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A 91: 6835-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol 25: 3431-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Helgason CD et al. (2000) A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med 191: 781-94 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Roes J & Rajewsky K (1993) Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med 177: 45-55 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol 15: 937-44 PubMed GONUTS page
  9. ↑ 9.0 9.1 Shahinian A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261: 609-12 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Oettgen HC et al. (1994) Active anaphylaxis in IgE-deficient mice. Nature 370: 367-70 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 Takai T et al. (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 379: 346-9 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Matsuuchi L et al. (1992) The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A 89: 3404-8 PubMed GONUTS page
  13. ↑ Amsen D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27: 89-99 PubMed GONUTS page
  14. ↑ Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10: 249-59 PubMed GONUTS page
  15. ↑ 15.0 15.1 Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96: 2277-83 PubMed GONUTS page
  16. ↑ 16.0 16.1 Kretschmer K et al. (2003) The selection of marginal zone B cells differs from that of B-1a cells. J Immunol 171: 6495-501 PubMed GONUTS page
  17. ↑ 17.0 17.1 Rahman ZS et al. (2003) Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 198: 1157-69 PubMed GONUTS page
  18. ↑ Erlandsson L et al. (2005) Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol 35: 1969-76 PubMed GONUTS page
  19. ↑ Scaglione BJ et al. (2007) Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol 139: 645-57 PubMed GONUTS page
  20. ↑ 20.0 20.1 Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page
  21. ↑ Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378: 303-6 PubMed GONUTS page
  22. ↑ 22.0 22.1 Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med 195: 461-72 PubMed GONUTS page
  24. ↑ Ng LG et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173: 807-17 PubMed GONUTS page
  25. ↑ Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171: 5562-70 PubMed GONUTS page
  26. ↑ Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916-20 PubMed GONUTS page
  27. ↑ Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page
  28. ↑ Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
  29. ↑ 29.0 29.1 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page
  30. ↑ Bry L & Brenner MB (2004) Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol 172: 433-41 PubMed GONUTS page


{{{LINEAGE}}}

Retrieved from "http://gowiki.tamu.edu/wiki/index.php/MGI:Ighm"
Personal tools
Namespaces
Variants
Actions
Navigation
Cacao
Journal Clubs
page contributors
Toolbox