MGI:Igf1r

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001965	G-protein alpha-subunit binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	F	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR002011	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0005010	insulin-like growth factor-activated receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0005158	insulin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2671700 PMID:12771153^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q99MR1 UniProtKB:Q60760	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2681062 PMID:12917015^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VH2	F	From MGI
	GO:0005520	insulin-like growth factor binding	MGI:MGI:2679358 PMID:14566968^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P05018	F	From MGI
	GO:0005520	insulin-like growth factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR016246 InterPro:IPR002011	F	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	C	From MGI
	GO:0005792	microsome	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3789406 PMID:18451178^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005901	caveola	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3774689 PMID:18216249^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006955	immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR002011	P	From MGI
	GO:0007409	axonogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0007420	brain development	MGI:MGI:2670470 PMID:12904469^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:2387729 PMID:12101187^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	From MGI
	GO:0016020	membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016246	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0030010	establishment of cell polarity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0030238	male sex determination	MGI:MGI:2680871 PMID:14628051^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0030879	mammary gland development	MGI:MGI:3722212 PMID:17662267^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	From MGI
	GO:0031017	exocrine pancreas development	MGI:MGI:2387729 PMID:12101187^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926486	P	From MGI
	GO:0031175	neuron projection development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0031994	insulin-like growth factor I binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0032467	positive regulation of cytokinesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0043005	neuron projection	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	C	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0043409	negative regulation of MAPK cascade	MGI:MGI:3789406 PMID:18451178^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:3789406 PMID:18451178^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	From MGI
	GO:0043548	phosphatidylinositol 3-kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0043559	insulin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0043560	insulin receptor substrate binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	F	From MGI
	GO:0043560	insulin receptor substrate binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	F	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0045768	positive regulation of anti-apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0046328	regulation of JNK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:MGI:2671700 PMID:12771153^[1]	IC: Inferred by Curator	GO:0005520	P	From MGI
	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0048015	phosphatidylinositol-mediated signaling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0051054	positive regulation of DNA metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0051262	protein tetramerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0051291	protein heterooligomerization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
	GO:0051389	inactivation of MAPKK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P08069	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:3789406 PMID:18451178^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	From MGI
	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:MGI:3789406 PMID:18451178^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	From MGI
	GO:0060740	prostate gland epithelium morphogenesis	MGI:MGI:3789406 PMID:18451178^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386328	P	From MGI
	GO:0090031	positive regulation of steroid hormone biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P24062	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Giovannone B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 278: 31564-73 PubMed GONUTS page
↑ MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page
↑ McCusker RH & Novakofski J (2003) Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol 197: 388-99 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Sutherland BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res 68: 3495-504 PubMed GONUTS page
↑ Gatchel JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A 105: 1291-6 PubMed GONUTS page
↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page
↑ Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page
↑ Heckman BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol 309: 137-49 PubMed GONUTS page

[PMID:12771153-0] 1.0 ^1.1 Giovannone B et al. (2003) Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem 278: 31564-73 PubMed GONUTS page

[PMID:12917015-1] MaCaulay SL et al. (2003) Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376: 123-34 PubMed GONUTS page

[PMID:14566968-2] McCusker RH & Novakofski J (2003) Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol 197: 388-99 PubMed GONUTS page

[PMID:18451178-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Sutherland BW et al. (2008) Conditional deletion of insulin-like growth factor-I receptor in prostate epithelium. Cancer Res 68: 3495-504 PubMed GONUTS page

[PMID:18216249-4] Gatchel JR et al. (2008) The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7. Proc Natl Acad Sci U S A 105: 1291-6 PubMed GONUTS page

[PMID:12904469-5] Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page

[PMID:12101187-6] 7.0 ^7.1 Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page

[PMID:14628051-7] Nef S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426: 291-5 PubMed GONUTS page

[PMID:17662267-8] Heckman BM et al. (2007) Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol 309: 137-49 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Igf1r ( synonyms: CD221, hyft, IGF-1R, line 186 )
Protein Name(s)	insulin-like growth factor I receptor,
External Links
MGI	MGI:96433

MGI:Igf1r

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