MGI:Igf1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:4366664 PMID:19744960^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0001974	blood vessel remodeling	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0005158	insulin receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	F	From MGI
	GO:0005159	insulin-like growth factor receptor binding	MGI:MGI:2679358 PMID:14566968^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q60751	F	From MGI
	GO:0005159	insulin-like growth factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	F	From MGI
	GO:0005159	insulin-like growth factor receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	F	From MGI
	GO:0005179	hormone activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	F	From MGI
	GO:0005179	hormone activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	F	From MGI
	GO:0005496	steroid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2679358 PMID:14566968^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q07079	F	From MGI
	GO:0005515	protein binding	MGI:MGI:52244 PMID:7679139^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P47876 UniProtKB:P47877 UniProtKB:P47878 UniProtKB:P47879	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR016179	C	From MGI
	GO:0005614	interstitial matrix	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2181561 PMID:9630227^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3761982 PMID:17693256^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:64922 PMID:7510770^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	C	From MGI
	GO:0006417	regulation of translation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:2670470 PMID:12904469^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:5294538 PMID:18977203^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007399	nervous system development	MGI:MGI:2450225 PMID:12574418^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0007613	memory	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR022341 InterPro:IPR022350	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3723572 PMID:17636024^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:109334 MGI:MGI:1932404	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0010001	glial cell differentiation	MGI:MGI:2450225 PMID:12574418^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0010613	positive regulation of cardiac muscle hypertrophy	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0014834	satellite cell maintenance involved in skeletal muscle regeneration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0014896	muscle hypertrophy	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0014904	myotube cell development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0014911	positive regulation of smooth muscle cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	MGI:MGI:1329746 PMID:10027293^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030104	water homeostasis	MGI:MGI:64922 PMID:7510770^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:95710	P	From MGI
	GO:0030166	proteoglycan biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0030307	positive regulation of cell growth	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0030324	lung development	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0030879	mammary gland development	MGI:MGI:3616136 PMID:15059953^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861704	P	From MGI
	GO:0031017	exocrine pancreas development	MGI:MGI:2387729 PMID:12101187^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0032878	regulation of establishment or maintenance of cell polarity	MGI:MGI:69105 PMID:7848824^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01343	P	From MGI
	GO:0033160	positive regulation of protein import into nucleus, translocation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0034392	negative regulation of smooth muscle cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0035264	multicellular organism growth	MGI:MGI:2670283 PMID:12865332^[16]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035630	bone mineralization involved in bone maturation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0042104	positive regulation of activated T cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0043388	positive regulation of DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0043539	protein serine/threonine kinase activator activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	F	From MGI
	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045445	myoblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045600	positive regulation of fat cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045725	positive regulation of glycogen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045768	positive regulation of anti-apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0045821	positive regulation of glycolysis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3512872 PMID:15322112^[17]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3758399 PMID:17644814^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0046326	positive regulation of glucose import	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0046579	positive regulation of Ras protein signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:MGI:2664440 PMID:12805218^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0048015	phosphatidylinositol-mediated signaling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0048146	positive regulation of fibroblast proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0048286	lung alveolus development	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0048286	lung alveolus development	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0048468	cell development	MGI:MGI:3624910 PMID:10465256^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857466	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0048754	branching morphogenesis of a tube	MGI:MGI:3616136 PMID:15059953^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861704	P	From MGI
	GO:0048839	inner ear development	MGI:MGI:5140238 PMID:21795542^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	MGI:MGI:3758399 PMID:17644814^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0051246	regulation of protein metabolic process	MGI:MGI:64922 PMID:7510770^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:95710	P	From MGI
	GO:0051450	myoblast proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:3837587 PMID:19208758^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051929	positive regulation of calcium ion transport via voltage-gated calcium channel activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0060426	lung vasculature development	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0060426	lung vasculature development	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0060463	lung lobe morphogenesis	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0060463	lung lobe morphogenesis	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0060509	Type I pneumocyte differentiation	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0060510	Type II pneumocyte differentiation	MGI:MGI:3640953 PMID:16691571^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926485	P	From MGI
	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	MGI:MGI:1336377 PMID:10218945^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857466	P	From MGI
	GO:0060736	prostate gland growth	MGI:MGI:3769830 PMID:17138659^[24]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060736	prostate gland growth	MGI:MGI:3822220 PMID:18827067^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152423	P	From MGI
	GO:0060740	prostate gland epithelium morphogenesis	MGI:MGI:3769830 PMID:17138659^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857466	P	From MGI
	GO:0060741	prostate gland stromal morphogenesis	MGI:MGI:3769830 PMID:17138659^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857466	P	From MGI
	GO:0060766	negative regulation of androgen receptor signaling pathway	MGI:MGI:3822220 PMID:18827067^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2152423	P	From MGI
	GO:0070373	negative regulation of ERK1 and ERK2 cascade	MGI:MGI:3640953 PMID:16691571^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:96787	P	From MGI
	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P05019	P	From MGI
	GO:0071902	positive regulation of protein serine/threonine kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0090031	positive regulation of steroid hormone biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63260	P	From MGI
	GO:0090201	negative regulation of release of cytochrome c from mitochondria	MGI:MGI:5294538 PMID:18977203^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:2000288	positive regulation of myoblast proliferation	MGI:MGI:5050608 PMID:21406500^[26]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page
↑ ^3.0 ^3.1 McCusker RH & Novakofski J (2003) Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol 197: 388-99 PubMed GONUTS page
↑ Donahue LR & Beamer WG (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol 136: 91-104 PubMed GONUTS page
↑ Teglund S et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-50 PubMed GONUTS page
↑ Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol 139: 431-9 PubMed GONUTS page
↑ Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page
↑ ^9.0 ^9.1 Sun X et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun 377: 1097-101 PubMed GONUTS page
↑ ^10.0 ^10.1 Vicario-Abejón C et al. (2003) Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci 23: 895-906 PubMed GONUTS page
↑ Podcheko A et al. (2007) Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol 27: 6484-96 PubMed GONUTS page
↑ Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page
↑ ^13.0 ^13.1 Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145: 3106-10 PubMed GONUTS page
↑ Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page
↑ Bègue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol 38: 405-20 PubMed GONUTS page
↑ Li Y et al. (2003) PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144: 3505-13 PubMed GONUTS page
↑ Viñals F & Ventura F (2004) Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. J Biol Chem 279: 45766-72 PubMed GONUTS page
↑ ^18.0 ^18.1 Kim JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J Biol Chem 282: 29359-67 PubMed GONUTS page
↑ Font de Mora J et al. (2003) Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J 22: 3039-49 PubMed GONUTS page
↑ Stefaneanu L et al. (1999) Somatotroph and lactotroph changes in the adenohypophyses of mice with disrupted insulin-like growth factor I gene. Endocrinology 140: 3881-9 PubMed GONUTS page
↑ Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci 31: 10903-18 PubMed GONUTS page
↑ Mukherjee A & Rotwein P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 122: 716-26 PubMed GONUTS page
↑ Ruan W et al. (1999) Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 140: 1984-9 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Kleinberg DL et al. (2007) Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice. Endocrinology 148: 1080-8 PubMed GONUTS page
↑ ^25.0 ^25.1 Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol 199: 489-97 PubMed GONUTS page
↑ Matheny RW Jr & Nindl BC (2011) Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation. Endocrinology 152: 1923-34 PubMed GONUTS page

[PMID:19744960-0] Giovannone B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet 18: 4629-39 PubMed GONUTS page

[PMID:16691571-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn 235: 2040-50 PubMed GONUTS page

[PMID:14566968-2] 3.0 ^3.1 McCusker RH & Novakofski J (2003) Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells. J Cell Physiol 197: 388-99 PubMed GONUTS page

[PMID:7679139-3] Donahue LR & Beamer WG (1993) Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J Endocrinol 136: 91-104 PubMed GONUTS page

[PMID:9630227-4] Teglund S et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-50 PubMed GONUTS page

[PMID:17693256-5] Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:7510770-6] 7.0 ^7.1 ^7.2 Donahue LR et al. (1993) Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice. J Endocrinol 139: 431-9 PubMed GONUTS page

[PMID:12904469-7] Schubert M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23: 7084-92 PubMed GONUTS page

[PMID:18977203-8] 9.0 ^9.1 Sun X et al. (2008) Akt activation prevents Apop-1-induced death of cells. Biochem Biophys Res Commun 377: 1097-101 PubMed GONUTS page

[PMID:12574418-9] 10.0 ^10.1 Vicario-Abejón C et al. (2003) Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci 23: 895-906 PubMed GONUTS page

[PMID:17636024-10] Podcheko A et al. (2007) Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. Mol Cell Biol 27: 6484-96 PubMed GONUTS page

[PMID:10027293-11] Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page

[PMID:15059953-12] 13.0 ^13.1 Richards RG et al. (2004) Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I. Endocrinology 145: 3106-10 PubMed GONUTS page

[PMID:12101187-13] Kido Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J Biol Chem 277: 36740-7 PubMed GONUTS page

[PMID:7848824-14] Bègue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol 38: 405-20 PubMed GONUTS page

[PMID:12865332-15] Li Y et al. (2003) PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144: 3505-13 PubMed GONUTS page

[PMID:15322112-16] Viñals F & Ventura F (2004) Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1. J Biol Chem 279: 45766-72 PubMed GONUTS page

[PMID:17644814-17] 18.0 ^18.1 Kim JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J Biol Chem 282: 29359-67 PubMed GONUTS page

[PMID:12805218-18] Font de Mora J et al. (2003) Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J 22: 3039-49 PubMed GONUTS page

[PMID:10465256-19] Stefaneanu L et al. (1999) Somatotroph and lactotroph changes in the adenohypophyses of mice with disrupted insulin-like growth factor I gene. Endocrinology 140: 3881-9 PubMed GONUTS page

[PMID:21795542-20] Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci 31: 10903-18 PubMed GONUTS page

[PMID:19208758-21] Mukherjee A & Rotwein P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 122: 716-26 PubMed GONUTS page

[PMID:10218945-22] Ruan W et al. (1999) Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 140: 1984-9 PubMed GONUTS page

[PMID:17138659-23] 24.0 ^24.1 ^24.2 Kleinberg DL et al. (2007) Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice. Endocrinology 148: 1080-8 PubMed GONUTS page

[PMID:18827067-24] 25.0 ^25.1 Svensson J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J Endocrinol 199: 489-97 PubMed GONUTS page

[PMID:21406500-25] Matheny RW Jr & Nindl BC (2011) Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation. Endocrinology 152: 1923-34 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Igf1 ( synonyms: Igf-1, Igf-I )
Protein Name(s)	insulin-like growth factor 1,
External Links
MGI	MGI:96432

MGI:Igf1

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