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MGI:Ift88
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ift88 ( synonyms: fxo, IFT88, Oak Ridge polycystic kidneys, orpk, polaris, Tg737, Tg737Rpw, TgN737Rpw, Ttc10 ) | |
| Protein Name(s) | intraflagellar transport 88 homolog (Chlamydomonas), | |
| External Links | ||
| MGI | MGI:98715 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0003382 |
epithelial cell morphogenesis |
MGI:MGI:4940123 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:1926671 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005814 |
centriole |
MGI:MGI:4457459 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005856 |
cytoskeleton |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0206 |
C |
From MGI |
||
| GO:0005929 |
cilium |
MGI:MGI:3692156 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:4457459 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005930 |
axoneme |
MGI:MGI:2664063 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005932 |
microtubule basal body |
MGI:MGI:2158985 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005932 |
microtubule basal body |
MGI:MGI:2664063 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005932 |
microtubule basal body |
MGI:MGI:4457459 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3579954 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3579954 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:1855904 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1859153 |
P |
From MGI |
||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0007399 |
nervous system development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0007420 |
brain development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:3045643 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:2660994 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3579954 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3579954 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0016485 |
protein processing |
MGI:MGI:3692156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1859153 |
P |
From MGI |
||
| GO:0019861 |
flagellum |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0282 |
C |
From MGI |
||
| GO:0021537 |
telencephalon development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0030030 |
cell projection organization |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0970 |
P |
From MGI |
||
| GO:0030324 |
lung development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0031512 |
motile primary cilium |
MGI:MGI:3806189 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031512 |
motile primary cilium |
MGI:MGI:5009180 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032391 |
photoreceptor connecting cilium |
MGI:MGI:3839506 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0032391 |
photoreceptor connecting cilium |
MGI:MGI:4460838 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035085 |
cilium axoneme |
MGI:MGI:4460838 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035085 |
cilium axoneme |
MGI:MGI:5009180 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042487 |
regulation of odontogenesis of dentin-containing tooth |
MGI:MGI:2660994 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:2660994 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3577662 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3579954 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3579954 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3692156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0042995 |
cell projection |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0966 |
C |
From MGI |
||
| GO:0045177 |
apical part of cell |
MGI:MGI:5009180 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045862 |
positive regulation of proteolysis |
MGI:MGI:3579954 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3027342 |
P |
From MGI |
||
| GO:0048568 |
embryonic organ development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0048598 |
embryonic morphogenesis |
MGI:MGI:3579954 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98297 |
P |
From MGI |
||
| GO:0048853 |
forebrain morphogenesis |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0060271 |
cilium morphogenesis |
MGI:MGI:1926671 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060271 |
cilium morphogenesis |
MGI:MGI:3692156 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1859153 |
P |
From MGI |
||
| GO:0060271 |
cilium morphogenesis |
MGI:MGI:4940123 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2157527 |
P |
From MGI |
||
| GO:0060411 |
cardiac septum morphogenesis |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
||
| GO:0060426 |
lung vasculature development |
MGI:MGI:3821634 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3823090 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Willaredt MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J Neurosci 28: 12887-900 PubMed GONUTS page
- ↑ 2.0 2.1 Blitzer AL et al. (2011) Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc Natl Acad Sci U S A 108: 2819-24 PubMed GONUTS page
- ↑ 3.0 3.1 Pazour GJ et al. (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151: 709-18 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Singla V et al. (2010) Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell 18: 410-24 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Haycraft CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53 PubMed GONUTS page
- ↑ 6.0 6.1 Taulman PD et al. (2001) Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol Biol Cell 12: 589-99 PubMed GONUTS page
- ↑ Hou X et al. (2002) Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest 109: 533-40 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Liu A et al. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132: 3103-11 PubMed GONUTS page
- ↑ Murcia NS et al. (2000) The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 127: 2347-55 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
- ↑ Cano DA et al. (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131: 3457-67 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Zhang Q et al. (2003) Loss of the Tg737 protein results in skeletal patterning defects. Dev Dyn 227: 78-90 PubMed GONUTS page
- ↑ Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Perrone CA et al. (2003) A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. Mol Biol Cell 14: 2041-56 PubMed GONUTS page
- ↑ Jiang ST et al. (2009) Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse. Hum Mol Genet 18: 1566-77 PubMed GONUTS page
- ↑ 16.0 16.1 Sedmak T & Wolfrum U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J Cell Biol 189: 171-86 PubMed GONUTS page
