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MGI:Icmt
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Icmt ( synonyms: Gm13095, HSTE14, pcCMT, prenylated protein carboxyl methyltransferase, prenylcysteine carboxyl methyltransferase, protein-S isoprenylcysteine O-methyltransferase, STE14 ) | |
| Protein Name(s) | isoprenylcysteine carboxyl methyltransferase, | |
| External Links | ||
| MGI | MGI:1888594 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001701 |
in utero embryonic development |
MGI:MGI:1930897 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:2182507 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183607 |
P |
From MGI |
||
| GO:0001889 |
liver development |
MGI:MGI:2182507 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183607 |
P |
From MGI |
||
| GO:0004671 |
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
MGI:MGI:1859528 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
F |
From MGI |
||
| GO:0004671 |
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
MGI:MGI:1930897 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
F |
From MGI |
||
| GO:0004671 |
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579844 |
F |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579844 |
C |
From MGI |
||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006479 |
protein methylation |
MGI:MGI:1930897 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
P |
From MGI |
||
| GO:0006481 |
C-terminal protein methylation |
MGI:MGI:1859528 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
P |
From MGI |
||
| GO:0006481 |
C-terminal protein methylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579844 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:1859528 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
P |
From MGI |
||
| GO:0008140 |
cAMP response element binding protein binding |
MGI:MGI:3029624 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3033709 |
F |
From MGI |
||
| GO:0008168 |
methyltransferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
F |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3029624 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3033709 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0032259 |
methylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0489 |
P |
From MGI |
||
| GO:0035264 |
multicellular organism growth |
MGI:MGI:1930897 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2680650 |
P |
From MGI |
||
| GO:0046498 |
S-adenosylhomocysteine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579844 |
P |
From MGI |
||
| GO:0046499 |
S-adenosylmethioninamine metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_579844 |
P |
From MGI |
||
| GO:0046578 |
regulation of Ras protein signal transduction |
MGI:MGI:3029624 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96680 |
P |
From MGI |
||
| GO:2001141 |
regulation of RNA biosynthetic process |
MGI:MGI:3029624 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3033709 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Bergo MO et al. (2001) Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem 276: 5841-5 PubMed GONUTS page
- ↑ 2.0 2.1 Lin X et al. (2002) Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology 123: 345-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Bergo MO et al. (2000) Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells. J Biol Chem 275: 17605-10 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Bergo MO et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest 113: 539-50 PubMed GONUTS page
