MGI:Hras1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0003924	GTPase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020849	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1197353 PMID:9488663^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q5EBH1	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3696331 PMID:16954213^[2]	IPI: Inferred from Physical Interaction	UniProtKB:PQ99N57	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3835718 PMID:18604197^[3]	IPI: Inferred from Physical Interaction	UniProtKB:B9EKT6	F	From MGI
	GO:0005525	GTP binding	MGI:MGI:3835718 PMID:18604197^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005525	GTP binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	F	From MGI
	GO:0005622	intracellular	MGI:MGI:1860165 PMID:10871846^[4]	TAS: Traceable Author Statement		C	From MGI
	GO:0005622	intracellular	MGI:MGI:3032880 PMID:14712229^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	C	From MGI
	GO:0006184	GTP catabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020849	P	From MGI
	GO:0006897	endocytosis	MGI:MGI:2449836 PMID:12446704^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:3696331 PMID:16954213^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:109326	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020849	P	From MGI
	GO:0007264	small GTPase mediated signal transduction	MGI:MGI:3032880 PMID:14712229^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007265	Ras protein signal transduction	MGI:MGI:1860165 PMID:10871846^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0007265	Ras protein signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0007569	cell aging	MGI:MGI:2670239 PMID:12878730^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007569	cell aging	MGI:MGI:3525039 PMID:15572682^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008022	protein C-terminus binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	F	From MGI
	GO:0008283	cell proliferation	MGI:MGI:3032880 PMID:14712229^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q91ZZ2	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3618985 PMID:16478791^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0008629	induction of apoptosis by intracellular signals	MGI:MGI:3696331 PMID:16954213^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4947150 PMID:21357543^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020849	C	From MGI
	GO:0031575	mitotic cell cycle G1/S transition checkpoint	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0043410	positive regulation of MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:1861510 PMID:10845775^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:1861510 PMID:10845775^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:97306 MGI:MGI:96680	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0045740	positive regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0046579	positive regulation of Ras protein signal transduction	MGI:MGI:3835226 PMID:19029245^[12]	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0048169	regulation of long-term neuronal synaptic plasticity	MGI:MGI:3580530 PMID:12427827^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3580632	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0051291	protein heterooligomerization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P20171	P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
	GO:0090398	cellular senescence	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01112	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Vavvas D et al. (1998) Identification of Nore1 as a potential Ras effector. J Biol Chem 273: 5439-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 An HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem 281: 33939-48 PubMed GONUTS page
↑ ^3.0 ^3.1 Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Ise K et al. (2000) Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 19: 2951-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page
↑ Sun P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278: 4063-71 PubMed GONUTS page
↑ Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100: 9354-9 PubMed GONUTS page
↑ Tarunina M et al. (2004) Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol 24: 10792-801 PubMed GONUTS page
↑ Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci 119: 819-27 PubMed GONUTS page
↑ Gimferrer I et al. (2011) Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol 186: 3892-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci 15: 398-407 PubMed GONUTS page
↑ Van Kanegan MJ & Strack S (2009) The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol 29: 662-74 PubMed GONUTS page
↑ Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci 22: 9721-32 PubMed GONUTS page

[PMID:9488663-0] Vavvas D et al. (1998) Identification of Nore1 as a potential Ras effector. J Biol Chem 273: 5439-42 PubMed GONUTS page

[PMID:16954213-1] 2.0 ^2.1 ^2.2 An HJ et al. (2006) Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem 281: 33939-48 PubMed GONUTS page

[PMID:18604197-2] 3.0 ^3.1 Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 10: 971-8 PubMed GONUTS page

[PMID:10871846-3] 4.0 ^4.1 Ise K et al. (2000) Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene 19: 2951-6 PubMed GONUTS page

[PMID:14712229-4] 5.0 ^5.1 ^5.2 Weissman JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23: 241-9 PubMed GONUTS page

[PMID:12446704-5] Sun P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem 278: 4063-71 PubMed GONUTS page

[PMID:12878730-6] Fingerle-Rowson G et al. (2003) The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A 100: 9354-9 PubMed GONUTS page

[PMID:15572682-7] Tarunina M et al. (2004) Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol 24: 10792-801 PubMed GONUTS page

[PMID:16478791-8] Park KS et al. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J Cell Sci 119: 819-27 PubMed GONUTS page

[PMID:21357543-9] Gimferrer I et al. (2011) Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol 186: 3892-8 PubMed GONUTS page

[PMID:10845775-10] 11.0 ^11.1 Vogel KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol Cell Neurosci 15: 398-407 PubMed GONUTS page

[PMID:19029245-11] Van Kanegan MJ & Strack S (2009) The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol 29: 662-74 PubMed GONUTS page

[PMID:12427827-12] Komiyama NH et al. (2002) SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci 22: 9721-32 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hras1 ( synonyms: c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras )
Protein Name(s)	Harvey rat sarcoma virus oncogene 1,
External Links
MGI	MGI:96224

MGI:Hras1

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