MGI:Hprt

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000287	magnesium ion binding	MGI:MGI:4459044		PANTHER:PTHR22573	F	From MGI
	GO:0000287	magnesium ion binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	F	From MGI
	GO:0001975	response to amphetamine	MGI:MGI:50371 PMID:1777100^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0001975	response to amphetamine	MGI:MGI:65928 PMID:1432691^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:1331314 PMID:10037486^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:2675193 PMID:12944494^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P27605	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:51991	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54095 PMID:943046^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54294 PMID:1235912^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54349 PMID:198184^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54423 PMID:204065^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54701 PMID:291939^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54768 PMID:540025^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:54860 PMID:6251472^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:55533 PMID:6852525^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:57368 PMID:2890215^[13]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:58084 PMID:2906327^[14]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:58177 PMID:3243423^[15]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:60112 PMID:8492116^[16]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:63603 PMID:3821905^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:63605 PMID:3029599^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857297	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:68205 PMID:6326107^[19]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:83266 PMID:8894695^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	F	From MGI
	GO:0004422	hypoxanthine phosphoribosyltransferase activity	MGI:MGI:85965 PMID:8878108^[21]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005625	soluble fraction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P27605	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:65752 PMID:8193672^[22]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:4459044		PANTHER:PTHR22573	C	From MGI
	GO:0006164	purine nucleotide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:1331314 PMID:10037486^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:2675193 PMID:12944494^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:52624 PMID:8485579^[23]	IGI: Inferred from Genetic Interaction	MGI:MGI:88061	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:52624 PMID:8485579^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006166	purine ribonucleoside salvage	MGI:MGI:60112 PMID:8492116^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006168	adenine salvage	MGI:MGI:1331314 PMID:10037486^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006178	guanine salvage	MGI:MGI:1331314 PMID:10037486^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0006178	guanine salvage	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0007610	behavior	MGI:MGI:2667736 PMID:12812988^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668517	P	From MGI
	GO:0007610	behavior	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0007625	grooming behavior	MGI:MGI:52624 PMID:8485579^[23]	IGI: Inferred from Genetic Interaction	MGI:MGI:88061	P	From MGI
	GO:0009116	nucleoside metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000836	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016757	transferase activity, transferring glycosyl groups	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0328	F	From MGI
	GO:0019835	cytolysis	MGI:MGI:2675193 PMID:12944494^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0021756	striatum development	MGI:MGI:1321418 PMID:9886073^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0021895	cerebral cortex neuron differentiation	MGI:MGI:3622601 PMID:11297820^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0021954	central nervous system neuron development	MGI:MGI:1321418 PMID:9886073^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0032263	GMP salvage	MGI:MGI:4459044		PANTHER:PTHR22573	P	From MGI
	GO:0032264	IMP salvage	MGI:MGI:4459044		PANTHER:PTHR22573	P	From MGI
	GO:0042417	dopamine metabolic process	MGI:MGI:1321418 PMID:9886073^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0042417	dopamine metabolic process	MGI:MGI:65928 PMID:1432691^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:3609918 PMID:11591653^[27]	IPI: Inferred from Physical Interaction	UniProtKB:P00493	F	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	F	From MGI
	GO:0043103	hypoxanthine salvage	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0045964	positive regulation of dopamine metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0045964	positive regulation of dopamine metabolic process	MGI:MGI:65825 PMID:7509865^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0046038	GMP catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0046040	IMP metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0046083	adenine metabolic process	MGI:MGI:83266 PMID:8894695^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:88061	P	From MGI
	GO:0046083	adenine metabolic process	MGI:MGI:83266 PMID:8894695^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0046100	hypoxanthine metabolic process	MGI:MGI:1331314 PMID:10037486^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0046100	hypoxanthine metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P27605	P	From MGI
	GO:0046100	hypoxanthine metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0046100	hypoxanthine metabolic process	MGI:MGI:54294 PMID:1235912^[6]	IC: Inferred by Curator	GO:0004422	P	From MGI
	GO:0046100	hypoxanthine metabolic process	MGI:MGI:63605 PMID:3029599^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857297	P	From MGI
	GO:0046651	lymphocyte proliferation	MGI:MGI:2675193 PMID:12944494^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048813	dendrite morphogenesis	MGI:MGI:3622601 PMID:11297820^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857299	P	From MGI
	GO:0051289	protein homotetramerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	P	From MGI
	GO:0052657	guanine phosphoribosyltransferase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P00492	F	From MGI
NOT	GO:0007625	grooming behavior	MGI:MGI:83266 PMID:8894695^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:88061	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jinnah HA et al. (1991) Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci 105: 1004-12 PubMed GONUTS page
↑ ^2.0 ^2.1 Jinnah HA et al. (1992) Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther 263: 596-607 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pelled D et al. (1999) Abnormal purine and pyrimidine nucleotide content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic mice. J Neurochem 72: 1139-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gu JJ et al. (2003) Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol 23: 6702-12 PubMed GONUTS page
↑ Chapman VM & Shows TB (1976) Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature 259: 665-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Kozak C et al. (1975) Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet 1: 371-82 PubMed GONUTS page
↑ Francke U et al. (1977) Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet 19: 57-84 PubMed GONUTS page
↑ Kozak CA & Ruddle FH (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet 3: 121-33 PubMed GONUTS page
↑ Francke U & Taggart RT (1979) Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse. Proc Natl Acad Sci U S A 76: 5230-3 PubMed GONUTS page
↑ Nesbitt MN et al. (1979) Isoenzyme pattern of HPRT in murine erythrocytes: control by an autosomal locus. Biochem Genet 17: 957-64 PubMed GONUTS page
↑ Francke U & Taggart RT (1980) Comparative gene mapping: order of loci on the X chromosome is different in mice and humans. Proc Natl Acad Sci U S A 77: 3595-9 PubMed GONUTS page
↑ Chapman VM et al. (1983) Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice. Genetics 103: 785-95 PubMed GONUTS page
↑ Chamberlain JS et al. (1987) Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome. Somat Cell Mol Genet 13: 671-8 PubMed GONUTS page
↑ Mullins LJ et al. (1988) Multilocus molecular mapping of the mouse X chromosome. Genomics 3: 187-94 PubMed GONUTS page
↑ Peters J et al. (1988) The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosome. Genet Res 52: 195-201 PubMed GONUTS page
↑ ^16.0 ^16.1 Jinnah HA et al. (1993) Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 60: 2036-45 PubMed GONUTS page
↑ Hooper M et al. (1987) HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326: 292-5 PubMed GONUTS page
↑ ^18.0 ^18.1 Kuehn MR et al. (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295-8 PubMed GONUTS page
↑ Melton DW et al. (1984) Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc Natl Acad Sci U S A 81: 2147-51 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Engle SJ et al. (1996) HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome. Hum Mol Genet 5: 1607-10 PubMed GONUTS page
↑ Plumb TJ et al. (1996) Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer. Neurosci Lett 214: 159-62 PubMed GONUTS page
↑ Ikeda K et al. (1993) Postnatal expression of hypoxanthine guanine phosphoribosyltransferase in the mouse brain. Enzyme Protein 47: 65-72 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Wu CL & Melton DW (1993) Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat Genet 3: 235-40 PubMed GONUTS page
↑ Jackson WS et al. (2003) Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet 12: 1621-9 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Jinnah HA et al. (1999) Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 72: 225-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Boer P et al. (2001) Decelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout mice. Neurosci Lett 303: 45-8 PubMed GONUTS page
↑ Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res 11: 1758-65 PubMed GONUTS page
↑ Jinnah HA et al. (1994) Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci 14: 1164-75 PubMed GONUTS page

{{{LINEAGE}}}

[PMID:1777100-0] Jinnah HA et al. (1991) Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci 105: 1004-12 PubMed GONUTS page

[PMID:1432691-1] 2.0 ^2.1 Jinnah HA et al. (1992) Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther 263: 596-607 PubMed GONUTS page

[PMID:10037486-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pelled D et al. (1999) Abnormal purine and pyrimidine nucleotide content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic mice. J Neurochem 72: 1139-45 PubMed GONUTS page

[PMID:12944494-3] 4.0 ^4.1 ^4.2 ^4.3 Gu JJ et al. (2003) Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol 23: 6702-12 PubMed GONUTS page

[PMID:943046-4] Chapman VM & Shows TB (1976) Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature 259: 665-7 PubMed GONUTS page

[PMID:1235912-5] 6.0 ^6.1 Kozak C et al. (1975) Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet 1: 371-82 PubMed GONUTS page

[PMID:198184-6] Francke U et al. (1977) Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet 19: 57-84 PubMed GONUTS page

[PMID:204065-7] Kozak CA & Ruddle FH (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet 3: 121-33 PubMed GONUTS page

[PMID:291939-8] Francke U & Taggart RT (1979) Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse. Proc Natl Acad Sci U S A 76: 5230-3 PubMed GONUTS page

[PMID:540025-9] Nesbitt MN et al. (1979) Isoenzyme pattern of HPRT in murine erythrocytes: control by an autosomal locus. Biochem Genet 17: 957-64 PubMed GONUTS page

[PMID:6251472-10] Francke U & Taggart RT (1980) Comparative gene mapping: order of loci on the X chromosome is different in mice and humans. Proc Natl Acad Sci U S A 77: 3595-9 PubMed GONUTS page

[PMID:6852525-11] Chapman VM et al. (1983) Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (HPRT) in wild-derived mice. Genetics 103: 785-95 PubMed GONUTS page

[PMID:2890215-12] Chamberlain JS et al. (1987) Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome. Somat Cell Mol Genet 13: 671-8 PubMed GONUTS page

[PMID:2906327-13] Mullins LJ et al. (1988) Multilocus molecular mapping of the mouse X chromosome. Genomics 3: 187-94 PubMed GONUTS page

[PMID:3243423-14] Peters J et al. (1988) The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosome. Genet Res 52: 195-201 PubMed GONUTS page

[PMID:8492116-15] 16.0 ^16.1 Jinnah HA et al. (1993) Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 60: 2036-45 PubMed GONUTS page

[PMID:3821905-16] Hooper M et al. (1987) HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326: 292-5 PubMed GONUTS page

[PMID:3029599-17] 18.0 ^18.1 Kuehn MR et al. (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295-8 PubMed GONUTS page

[PMID:6326107-18] Melton DW et al. (1984) Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc Natl Acad Sci U S A 81: 2147-51 PubMed GONUTS page

[PMID:8894695-19] 20.0 ^20.1 ^20.2 ^20.3 Engle SJ et al. (1996) HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome. Hum Mol Genet 5: 1607-10 PubMed GONUTS page

[PMID:8878108-20] Plumb TJ et al. (1996) Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer. Neurosci Lett 214: 159-62 PubMed GONUTS page

[PMID:8193672-21] Ikeda K et al. (1993) Postnatal expression of hypoxanthine guanine phosphoribosyltransferase in the mouse brain. Enzyme Protein 47: 65-72 PubMed GONUTS page

[PMID:8485579-22] 23.0 ^23.1 ^23.2 Wu CL & Melton DW (1993) Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice. Nat Genet 3: 235-40 PubMed GONUTS page

[PMID:12812988-23] Jackson WS et al. (2003) Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet 12: 1621-9 PubMed GONUTS page

[PMID:9886073-24] 25.0 ^25.1 ^25.2 Jinnah HA et al. (1999) Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 72: 225-9 PubMed GONUTS page

[PMID:11297820-25] 26.0 ^26.1 Boer P et al. (2001) Decelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout mice. Neurosci Lett 303: 45-8 PubMed GONUTS page

[PMID:11591653-26] Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res 11: 1758-65 PubMed GONUTS page

[PMID:7509865-27] Jinnah HA et al. (1994) Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci 14: 1164-75 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hprt ( synonyms: Hprt1 )
Protein Name(s)	hypoxanthine guanine phosphoribosyl transferase,
External Links
MGI	MGI:96217

MGI:Hprt

Contents

Annotations

Notes

References

a

b

c

d

g

g cont.

h

i

l

m

n

p

r

s

t

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox