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MGI:Hpn
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hpn | |
| Protein Name(s) | hepsin, | |
| External Links | ||
| MGI | MGI:1196620 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004252 |
serine-type endopeptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005044 |
scavenger receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2670479 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0006508 |
proteolysis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006898 |
receptor-mediated endocytosis |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008233 |
peptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008236 |
serine-type peptidase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008360 |
regulation of cell shape |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010756 |
positive regulation of plasminogen activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0015269 |
calcium-activated potassium channel activity |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034769 |
basement membrane disassembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:5308539 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043923 |
positive regulation by host of viral transcription |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050910 |
detection of mechanical stimulus involved in sensory perception of sound |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050910 |
detection of mechanical stimulus involved in sensory perception of sound |
MGI:MGI:5306554 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050910 |
detection of mechanical stimulus involved in sensory perception of sound |
MGI:MGI:5308539 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070008 |
serine-type exopeptidase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0071805 |
potassium ion transmembrane transport |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:5306554 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0097066 |
response to thyroid hormone stimulus |
MGI:MGI:5306554 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0097195 |
pilomotor reflex |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000347 |
positive regulation of hepatocyte proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000611 |
positive regulation of thyroid hormone generation |
MGI:MGI:3719967 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hooper JD et al. (2003) Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Biochem J 373: 689-702 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Guipponi M et al. (2007) Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. Am J Pathol 171: 608-16 PubMed GONUTS page
- ↑ 3.0 3.1 Guipponi M et al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum Mutat 29: 130-41 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hanifa S et al. (2010) Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice. Neuroreport 21: 897-901 PubMed GONUTS page
