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MGI:Hoxd13
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hoxd13 ( synonyms: Hox-4.8, spdh ) | |
| Protein Name(s) | homeobox D13, | |
| External Links | ||
| MGI | MGI:96205 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001501 |
skeletal system development |
MGI:MGI:63627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0001501 |
skeletal system development |
MGI:MGI:80097 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2151805 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:3829797 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3629247 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3620476 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3527920 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:2177382 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857397 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:63627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:83869 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96203 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:63627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0022612 |
gland morphogenesis |
MGI:MGI:86772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0030326 |
embryonic limb morphogenesis |
MGI:MGI:2177382 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857397 |
P |
From MGI |
||
| GO:0030539 |
male genitalia development |
MGI:MGI:63627 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:2150573 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857397 |
P |
From MGI |
||
| GO:0035108 |
limb morphogenesis |
MGI:MGI:84613 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95462 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2177382 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857397 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:1097490 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1918115 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:3765370 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96204 |
P |
From MGI |
||
| GO:0042733 |
embryonic digit morphogenesis |
MGI:MGI:83869 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96203 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3620476 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3629247 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3829797 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048619 |
embryonic hindgut morphogenesis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001099356 |
P |
From MGI |
||
| GO:0060527 |
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
MGI:MGI:2653645 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107730 |
P |
From MGI |
||
| GO:0060571 |
morphogenesis of an epithelial fold |
MGI:MGI:86772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0060602 |
branch elongation of an epithelium |
MGI:MGI:86772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
||
| GO:0060687 |
regulation of branching involved in prostate gland morphogenesis |
MGI:MGI:86772 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857871 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Dollé P et al. (1993) Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75: 431-41 PubMed GONUTS page
- ↑ Davis AP & Capecchi MR (1996) A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse. Development 122: 1175-85 PubMed GONUTS page
- ↑ 3.0 3.1 Kawakami Y et al. (2009) Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development 136: 585-94 PubMed GONUTS page
- ↑ 4.0 4.1 Capellini TD et al. (2006) Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development 133: 2263-73 PubMed GONUTS page
- ↑ 5.0 5.1 Salsi V & Zappavigna V (2006) Hoxd13 and Hoxa13 directly control the expression of the EphA7 Ephrin tyrosine kinase receptor in developing limbs. J Biol Chem 281: 1992-9 PubMed GONUTS page
- ↑ Williams TM et al. (2005) Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol 277: 457-71 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Albrecht AN et al. (2002) The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev 112: 53-67 PubMed GONUTS page
- ↑ 8.0 8.1 Zákány J & Duboule D (1996) Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature 384: 69-71 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Podlasek CA et al. (1997) Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13. Dev Dyn 208: 454-65 PubMed GONUTS page
- ↑ Bruneau S et al. (2001) The mouse Hoxd13(spdh) mutation, a polyalanine expansion similar to human type II synpolydactyly (SPD), disrupts the function but not the expression of other Hoxd genes. Dev Biol 237: 345-53 PubMed GONUTS page
- ↑ Hérault Y et al. (1996) Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J 15: 6727-38 PubMed GONUTS page
- ↑ Hérault Y et al. (1997) Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Development 124: 3493-500 PubMed GONUTS page
- ↑ Sheth R et al. (2007) Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev Biol 310: 430-41 PubMed GONUTS page
- ↑ Economides KD & Capecchi MR (2003) Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development 130: 2061-9 PubMed GONUTS page
