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MGI:Hoxb1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Hoxb1 ( synonyms: Hox-2.9 )
Protein Name(s) homeobox B1,
External Links
MGI MGI:96182

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003677

DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P14653

F

From MGI

GO:0003677

DNA binding

MGI:MGI:67108
PMID:7911971[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR001356

F

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P14653

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P14653

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR017970
InterPro:IPR001356

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0009653

anatomical structure morphogenesis

MGI:MGI:1346308
PMID:10529420[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:96170

P

From MGI

GO:0009952

anterior/posterior pattern specification

MGI:MGI:1346308
PMID:10529420[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:96170

P

From MGI

GO:0009952

anterior/posterior pattern specification

MGI:MGI:1859107
PMID:10885747[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:96183
MGI:MGI:96184
MGI:MGI:96185
MGI:MGI:96186
MGI:MGI:96187
MGI:MGI:96188
MGI:MGI:96189
MGI:MGI:96190

P

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P14653

F

From MGI

GO:0021546

rhombomere development

MGI:MGI:4949985
PMID:21320481[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0021570

rhombomere 4 development

MGI:MGI:1346308
PMID:10529420[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:96170

P

From MGI

GO:0021571

rhombomere 5 development

MGI:MGI:1346308
PMID:10529420[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:96170

P

From MGI

GO:0021612

facial nerve structural organization

MGI:MGI:83677
PMID:8898234[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857824

P

From MGI

GO:0021754

facial nucleus development

MGI:MGI:83677
PMID:8898234[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857824

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:3817812
PMID:18787068[6]

IGI: Inferred from Genetic Interaction

MGI:MGI:97495

F

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3817812
PMID:18787068[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0048646

anatomical structure formation involved in morphogenesis

MGI:MGI:1346308
PMID:10529420[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:96170

P

From MGI

GO:0048704

embryonic skeletal system morphogenesis

MGI:MGI:1859107
PMID:10885747[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:96183
MGI:MGI:96184
MGI:MGI:96185
MGI:MGI:96186
MGI:MGI:96187
MGI:MGI:96188
MGI:MGI:96189
MGI:MGI:96190

P

From MGI

contributes_to

GO:0003677

DNA binding

MGI:MGI:894947
PMID:9242495[7]

IDA: Inferred from Direct Assay

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Pellerin I et al. (1994) Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster. Mol Cell Biol 14: 4532-45 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Rossel M & Capecchi MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126: 5027-40 PubMed GONUTS page
  3. 3.0 3.1 Medina-Martínez O et al. (2000) A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Dev Biol 222: 71-83 PubMed GONUTS page
  4. Wong EY et al. (2011) Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning. Dev Biol 352: 382-92 PubMed GONUTS page
  5. 5.0 5.1 Goddard JM et al. (1996) Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122: 3217-28 PubMed GONUTS page
  6. 6.0 6.1 Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135: 3369-78 PubMed GONUTS page
  7. Maconochie MK et al. (1997) Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev 11: 1885-95 PubMed GONUTS page
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