MGI:Hoxa1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR009057	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001356	F	From MGI
	GO:0005634	nucleus	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0539	C	From MGI
	GO:0005634	nucleus	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017970	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0805	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017970 InterPro:IPR001356	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:3056028 PMID:15465489^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007399	nervous system development	MGI:MGI:3055618 PMID:15367676^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056069	P	From MGI
	GO:0007605	sensory perception of sound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0007634	optokinetic behavior	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0008045	motor axon guidance	MGI:MGI:1306866 PMID:9806922^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95296	P	From MGI
	GO:0009653	anatomical structure morphogenesis	MGI:MGI:1346308 PMID:10529420^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:96182	P	From MGI
	GO:0009653	anatomical structure morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:1346308 PMID:10529420^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:96182	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:3055618 PMID:15367676^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056069	P	From MGI
	GO:0021569	rhombomere 3 development	MGI:MGI:1306866 PMID:9806922^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95296	P	From MGI
	GO:0021569	rhombomere 3 development	MGI:MGI:1306866 PMID:9806922^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021570	rhombomere 4 development	MGI:MGI:1306866 PMID:9806922^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021570	rhombomere 4 development	MGI:MGI:1346308 PMID:10529420^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:96182	P	From MGI
	GO:0021570	rhombomere 4 development	MGI:MGI:62658 PMID:8102800^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021571	rhombomere 5 development	MGI:MGI:1306866 PMID:9806922^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021571	rhombomere 5 development	MGI:MGI:1346308 PMID:10529420^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:96182	P	From MGI
	GO:0021571	rhombomere 5 development	MGI:MGI:62658 PMID:8102800^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021599	abducens nerve formation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0021612	facial nerve structural organization	MGI:MGI:1306866 PMID:9806922^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95296	P	From MGI
	GO:0021754	facial nucleus development	MGI:MGI:62658 PMID:8102800^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0021953	central nervous system neuron differentiation	MGI:MGI:1306866 PMID:9806922^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857504	P	From MGI
	GO:0030902	hindbrain development	MGI:MGI:3055618 PMID:15367676^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056069	P	From MGI
	GO:0042472	inner ear morphogenesis	MGI:MGI:3055618 PMID:15367676^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3056069	P	From MGI
	GO:0042473	outer ear morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR017970 InterPro:IPR001356	F	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3817812 PMID:18787068^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048646	anatomical structure formation involved in morphogenesis	MGI:MGI:1346308 PMID:10529420^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:96182	P	From MGI
	GO:0048702	embryonic neurocranium morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0048839	inner ear development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0048844	artery morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0050795	regulation of behavior	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0050890	cognition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0050905	neuromuscular process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0060840	artery development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0060876	semicircular canal formation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0090102	cochlea development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
	GO:0090103	cochlea morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P49639	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Pruitt SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr Patterns 4: 671-85 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Remacle S et al. (2004) Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol 24: 8567-75 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Helmbacher F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development 125: 4739-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Rossel M & Capecchi MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126: 5027-40 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Dollé P et al. (1993) Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A 90: 7666-70 PubMed GONUTS page
↑ Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135: 3369-78 PubMed GONUTS page

[PMID:15465489-0] Pruitt SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr Patterns 4: 671-85 PubMed GONUTS page

[PMID:15367676-1] 2.0 ^2.1 ^2.2 ^2.3 Remacle S et al. (2004) Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol 24: 8567-75 PubMed GONUTS page

[PMID:9806922-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Helmbacher F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development 125: 4739-48 PubMed GONUTS page

[PMID:10529420-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Rossel M & Capecchi MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126: 5027-40 PubMed GONUTS page

[PMID:8102800-4] 5.0 ^5.1 ^5.2 Dollé P et al. (1993) Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc Natl Acad Sci U S A 90: 7666-70 PubMed GONUTS page

[PMID:18787068-5] Wassef MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135: 3369-78 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hoxa1 ( synonyms: early retinoic acid, ERA1, Hox-1.6 )
Protein Name(s)	homeobox A1,
External Links
MGI	MGI:96170

MGI:Hoxa1

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