MGI:Hnf4a

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000062	fatty-acyl-CoA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3050203 PMID:15014077^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3511724 PMID:15581617^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3654711 PMID:16912278^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:75752 PMID:7615825^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3575336 PMID:15761495^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3619855 PMID:16498401^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:75752 PMID:7615825^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:1888589 PMID:10859308^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003707	steroid hormone receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR001723	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003068	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0005504	fatty acid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0005504	fatty acid binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3760208 PMID:17636037^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9WTN3	F	From MGI
	GO:0005634	nucleus	MGI:MGI:1101555 PMID:9408084^[9]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:1195513 PMID:9421506^[10]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3575862 PMID:15767668^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3619787 PMID:16537911^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3688957 PMID:17021047^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	C	From MGI
	GO:0005634	nucleus	MGI:MGI:64328 PMID:8306889^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:75752 PMID:7615825^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:85762 PMID:9053305^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158682	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003068	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0006591	ornithine metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:3619855 PMID:16498401^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3622274	P	From MGI
	GO:0006637	acyl-CoA metabolic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0006805	xenobiotic metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0007164	establishment of tissue polarity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0007548	sex differentiation	MGI:MGI:3769852 PMID:17412818^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183520	P	From MGI
	GO:0007596	blood coagulation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001628 InterPro:IPR013088	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:3575336 PMID:15761495^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0010470	regulation of gastrulation	MGI:MGI:69170 PMID:7958910^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2158682	P	From MGI
	GO:0016290	palmitoyl-CoA hydrolase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0019216	regulation of lipid metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0023019	signal transduction involved in regulation of gene expression	MGI:MGI:4415813 PMID:18462699^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0032534	regulation of microvillus assembly	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0033159	negative regulation of protein import into nucleus, translocation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0033613	activating transcription factor binding	MGI:MGI:3813432 PMID:17932483^[19]	IPI: Inferred from Physical Interaction	UniProtKB:O35740	F	From MGI
	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3575336 PMID:15761495^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0043401	steroid hormone mediated signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536	P	From MGI
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:64328 PMID:8306889^[14]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:3575336 PMID:15761495^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	F	From MGI
	GO:0045216	cell-cell junction organization	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045722	positive regulation of gluconeogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045723	positive regulation of fatty acid biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1101555 PMID:9408084^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1195513 PMID:9421506^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0045930	negative regulation of mitotic cell cycle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1888589 PMID:10859308^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1930468 PMID:11158324^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3511724 PMID:15581617^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3575336 PMID:15761495^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3619787 PMID:16537911^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3622274	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3624152 PMID:16527247^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3760208 PMID:17636037^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3760208 PMID:17636037^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1276523 MGI:MGI:1276533 MGI:MGI:1276535	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3760208 PMID:17636037^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:1342774	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:75752 PMID:7615825^[4]	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:3575336 PMID:15761495^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0055088	lipid homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P41235	P	From MGI
	GO:0055091	phospholipid homeostasis	MGI:MGI:1930468 PMID:11158324^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060395	SMAD protein signal transduction	MGI:MGI:1195384 PMID:9420335^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070328	triglyceride homeostasis	MGI:MGI:1930468 PMID:11158324^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070491	repressing transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P22449	F	From MGI
	GO:2000189	positive regulation of cholesterol homeostasis	MGI:MGI:1930468 PMID:11158324^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Paré JF et al. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem 279: 21206-16 PubMed GONUTS page
↑ ^2.0 ^2.1 Kamiya A et al. (2004) Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett 578: 63-8 PubMed GONUTS page
↑ Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev 20: 2293-305 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Ginsburg GS et al. (1995) Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. J Clin Invest 96: 528-38 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gupta RK et al. (2005) The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest 115: 1006-15 PubMed GONUTS page
↑ ^6.0 ^6.1 Briançon N & Weiss MC (2006) In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J 25: 1253-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Antes TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J Biol Chem 275: 26637-48 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ponugoti B et al. (2007) Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol 21: 2698-712 PubMed GONUTS page
↑ ^9.0 ^9.1 Yokomori N et al. (1997) Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver. J Steroid Biochem Mol Biol 62: 307-14 PubMed GONUTS page
↑ ^10.0 ^10.1 Nakhei H et al. (1998) An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types. Nucleic Acids Res 26: 497-504 PubMed GONUTS page
↑ Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol 25: 2622-31 PubMed GONUTS page
↑ ^12.0 ^12.1 Sadagurski M et al. (2006) Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol 26: 2675-87 PubMed GONUTS page
↑ Yamasaki H et al. (2006) Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133: 4233-43 PubMed GONUTS page
↑ ^14.0 ^14.1 Ang SL et al. (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119: 1301-15 PubMed GONUTS page
↑ Duncan SA et al. (1997) Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development 124: 279-87 PubMed GONUTS page
↑ Laz EV et al. (2007) Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology 148: 3327-37 PubMed GONUTS page
↑ Chen WS et al. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8: 2466-77 PubMed GONUTS page
↑ Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page
↑ Qu X et al. (2007) Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J 26: 4445-56 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Hayhurst GP et al. (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21: 1393-403 PubMed GONUTS page
↑ Furihata T et al. (2006) Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver. Arch Biochem Biophys 447: 107-17 PubMed GONUTS page
↑ Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-19 PubMed GONUTS page

[PMID:15014077-0] Paré JF et al. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem 279: 21206-16 PubMed GONUTS page

[PMID:15581617-1] 2.0 ^2.1 Kamiya A et al. (2004) Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett 578: 63-8 PubMed GONUTS page

[PMID:16912278-2] Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev 20: 2293-305 PubMed GONUTS page

[PMID:7615825-3] 4.0 ^4.1 ^4.2 ^4.3 Ginsburg GS et al. (1995) Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4. J Clin Invest 96: 528-38 PubMed GONUTS page

[PMID:15761495-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gupta RK et al. (2005) The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest 115: 1006-15 PubMed GONUTS page

[PMID:16498401-5] 6.0 ^6.1 Briançon N & Weiss MC (2006) In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J 25: 1253-62 PubMed GONUTS page

[PMID:10859308-6] 7.0 ^7.1 Antes TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine. J Biol Chem 275: 26637-48 PubMed GONUTS page

[PMID:17636037-7] 8.0 ^8.1 ^8.2 ^8.3 Ponugoti B et al. (2007) Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol 21: 2698-712 PubMed GONUTS page

[PMID:9408084-8] 9.0 ^9.1 Yokomori N et al. (1997) Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver. J Steroid Biochem Mol Biol 62: 307-14 PubMed GONUTS page

[PMID:9421506-9] 10.0 ^10.1 Nakhei H et al. (1998) An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types. Nucleic Acids Res 26: 497-504 PubMed GONUTS page

[PMID:15767668-10] Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol 25: 2622-31 PubMed GONUTS page

[PMID:16537911-11] 12.0 ^12.1 Sadagurski M et al. (2006) Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol 26: 2675-87 PubMed GONUTS page

[PMID:17021047-12] Yamasaki H et al. (2006) Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133: 4233-43 PubMed GONUTS page

[PMID:8306889-13] 14.0 ^14.1 Ang SL et al. (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119: 1301-15 PubMed GONUTS page

[PMID:9053305-14] Duncan SA et al. (1997) Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development 124: 279-87 PubMed GONUTS page

[PMID:17412818-15] Laz EV et al. (2007) Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology 148: 3327-37 PubMed GONUTS page

[PMID:7958910-16] Chen WS et al. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev 8: 2466-77 PubMed GONUTS page

[PMID:18462699-17] Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page

[PMID:17932483-18] Qu X et al. (2007) Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J 26: 4445-56 PubMed GONUTS page

[PMID:11158324-19] 20.0 ^20.1 ^20.2 ^20.3 Hayhurst GP et al. (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21: 1393-403 PubMed GONUTS page

[PMID:16527247-20] Furihata T et al. (2006) Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver. Arch Biochem Biophys 447: 107-17 PubMed GONUTS page

[PMID:9420335-21] Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-19 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hnf4a ( synonyms: HNF-4, Hnf4, HNF4 alpha, MODY1, Nr2a1, Nuclear receptor 2A1, Tcf14, Tcf4 )
Protein Name(s)	hepatic nuclear factor 4, alpha,
External Links
MGI	MGI:109128

MGI:Hnf4a

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