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MGI:Hmgcr
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hmgcr ( synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red ) | |
| Protein Name(s) | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, | |
| External Links | ||
| MGI | MGI:96159 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:2157179 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:2180727 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:2386518 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:2679748 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:3603108 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:3603484 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:49557 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:70238 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004420 |
hydroxymethylglutaryl-CoA reductase (NADPH) activity |
MGI:MGI:892202 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:3603484 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:49557 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006695 |
cholesterol biosynthetic process |
MGI:MGI:2180727 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006695 |
cholesterol biosynthetic process |
MGI:MGI:3603484 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006695 |
cholesterol biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006695 |
cholesterol biosynthetic process |
MGI:MGI:70238 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006743 |
ubiquinone metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008299 |
isoprenoid biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008542 |
visual learning |
MGI:MGI:3610917 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0009790 |
embryo development |
MGI:MGI:2679748 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2682329 |
P |
From MGI |
||
| GO:0010664 |
negative regulation of striated muscle cell apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010666 |
positive regulation of cardiac muscle cell apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016491 |
oxidoreductase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0560 |
F |
From MGI |
||
| GO:0032874 |
positive regulation of stress-activated MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042282 |
hydroxymethylglutaryl-CoA reductase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043407 |
negative regulation of MAP kinase activity |
MGI:MGI:3610917 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97306 |
P |
From MGI |
||
| GO:0045908 |
negative regulation of vasodilation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048643 |
positive regulation of skeletal muscle tissue development |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061045 |
negative regulation of wound healing |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061179 |
negative regulation of insulin secretion involved in cellular response to glucose stimulus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hogenboom S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J Lipid Res 43: 90-8 PubMed GONUTS page
- ↑ 2.0 2.1 Plump AS et al. (1996) Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production. J Clin Invest 97: 2660-71 PubMed GONUTS page
- ↑ Hyogo H et al. (2002) Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem 277: 34117-24 PubMed GONUTS page
- ↑ 4.0 4.1 Ohashi K et al. (2003) Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem 278: 42936-41 PubMed GONUTS page
- ↑ Engelking LJ et al. (2005) Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 115: 2489-98 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Wu MK & Cohen DE (2005) Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Am J Physiol Gastrointest Liver Physiol 289: G456-61 PubMed GONUTS page
- ↑ 7.0 7.1 Hwa JJ et al. (1992) Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression. J Lipid Res 33: 711-25 PubMed GONUTS page
- ↑ 8.0 8.1 Goodrum JF et al. (1995) Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64: 408-16 PubMed GONUTS page
- ↑ Plump AS et al. (1997) ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res 38: 1033-47 PubMed GONUTS page
- ↑ 10.0 10.1 Raben N et al. (2002) Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme. Mol Ther 6: 601-8 PubMed GONUTS page
