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MGI:Hipk2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hipk2 ( synonyms: Stank ) | |
| Protein Name(s) | homeodomain interacting protein kinase 2, | |
| External Links | ||
| MGI | MGI:1314872 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001102 |
RNA polymerase II activating transcription factor binding |
MGI:MGI:5306308 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:1926651 |
ISA: Inferred from Sequence Alignment |
F |
From MGI |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
MGI:MGI:5306308 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1303245 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3040155 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3521522 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3829121 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3619785 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1314872 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4818711 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1927371 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005813 |
centrosome |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0227 |
P |
From MGI |
||
| GO:0006978 |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:3696537 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3487301 |
P |
From MGI |
||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:3619785 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1314872 |
P |
From MGI |
||
| GO:0007628 |
adult walking behavior |
MGI:MGI:3696537 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3487301 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3619785 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1314872 |
P |
From MGI |
||
| GO:0008344 |
adult locomotory behavior |
MGI:MGI:3696537 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3487301 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3619785 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1314872 |
P |
From MGI |
||
| GO:0010842 |
retina layer formation |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016604 |
nuclear body |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016605 |
PML body |
MGI:MGI:2449749 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:5306308 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018107 |
peptidyl-threonine phosphorylation |
MGI:MGI:5306308 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030182 |
neuron differentiation |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030514 |
negative regulation of BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031965 |
nuclear membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:5306308 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
MGI:MGI:3619785 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1314872 |
P |
From MGI |
||
| GO:0043388 |
positive regulation of DNA binding |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3696537 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3487301 |
P |
From MGI |
||
| GO:0045766 |
positive regulation of angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3696537 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201674 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5306308 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046330 |
positive regulation of JNK cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046790 |
virion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048596 |
embryonic camera-type eye morphogenesis |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050882 |
voluntary musculoskeletal movement |
MGI:MGI:3696537 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3487301 |
P |
From MGI |
||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:5306308 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060059 |
embryonic retina morphogenesis in camera-type eye |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060235 |
lens induction in camera-type eye |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060395 |
SMAD protein signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0061072 |
iris morphogenesis |
MGI:MGI:4818711 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
|
NOT |
GO:0003677 |
DNA binding |
MGI:MGI:1303245 |
IDA: Inferred from Direct Assay |
F |
From MGI |
||
|
contributes_to |
GO:0001105 |
RNA polymerase II transcription coactivator activity |
MGI:MGI:5306308 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Kim YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 273: 25875-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Kim EA et al. (2006) Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J Biol Chem 281: 7489-97 PubMed GONUTS page
- ↑ Ebling FJ et al. (2000) Estrogenic induction of spermatogenesis in the hypogonadal mouse. Endocrinology 141: 2861-9 PubMed GONUTS page
- ↑ Kanei-Ishii C et al. (2004) Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev 18: 816-29 PubMed GONUTS page
- ↑ Rui Y et al. (2004) Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J 23: 4583-94 PubMed GONUTS page
- ↑ Choi DW et al. (2008) Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. J Biol Chem 283: 4682-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Isono K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol 26: 2758-71 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Inoue T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett 584: 3233-8 PubMed GONUTS page
- ↑ Wang W et al. (2000) Identification and cloning of a CD43-associated serine/threonine kinase. Cell Immunol 205: 34-9 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Zhang J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci 10: 77-86 PubMed GONUTS page
- ↑ Ecsedy JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol 23: 950-60 PubMed GONUTS page
