MGI:Hif1a

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0071279	cellular response to cobalt ion	PMID:19915160^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 2	complete
	GO:0000988	protein binding transcription factor activity	MGI:MGI:4459348 PMID:20440072^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P53762	F	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:5306879 PMID:21856340^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3039988 PMID:15073147^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:3607736 PMID:14659802^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179429	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:1195604 PMID:9436976^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:1261710 PMID:9606183^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385358	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:1332371 PMID:10074486^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:2157266 PMID:11792862^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:2158032 PMID:11801735^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:2176655 PMID:11782478^[11]	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:3709696 PMID:17437992^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:96552	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:82592 PMID:8702901^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001755	neural crest cell migration	MGI:MGI:3607736 PMID:14659802^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179429	P	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:3772289 PMID:18037992^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:3703383 PMID:16287860^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:109169	P	From MGI
	GO:0001892	embryonic placenta development	MGI:MGI:3703383 PMID:16287860^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179429	P	From MGI
	GO:0001922	B-1 B cell homeostasis	MGI:MGI:2159073 PMID:11854513^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001944	vasculature development	MGI:MGI:3807101 PMID:18653562^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:1306784	P	From MGI
	GO:0001947	heart looping	MGI:MGI:3607736 PMID:14659802^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2179429	P	From MGI
	GO:0002052	positive regulation of neuroblast proliferation	MGI:MGI:3695975 PMID:17215402^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:103178	P	From MGI
	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	MGI:MGI:3772289 PMID:18037992^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003151	outflow tract morphogenesis	MGI:MGI:1195604 PMID:9436976^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0003208	cardiac ventricle morphogenesis	MGI:MGI:1195604 PMID:9436976^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:3056854 PMID:15456877^[19]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:894004 PMID:9113979^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:88071	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2176655 PMID:11782478^[11]	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3056854 PMID:15456877^[19]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0004871	signal transducer activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3046599 PMID:15225651^[21]	IPI: Inferred from Physical Interaction	UniProtKB:P63166	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4461337 PMID:20609350^[22]	IPI: Inferred from Physical Interaction	UniProtKB:P35583 UniProtKB:Q09472	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5289736 PMID:21871655^[23]	IPI: Inferred from Physical Interaction	UniProtKB:P51450-2 UniProtKB:Q8BIF2	F	From MGI
	GO:0005515	protein binding	MGI:MGI:82592 PMID:8702901^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P53762	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2153426 PMID:11691837^[24]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3045517 PMID:15016652^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3056854 PMID:15456877^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4459348 PMID:20440072^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:A8MYV6	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5315694 PMID:18295594^[26]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	C	From MGI
	GO:0005730	nucleolus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:A8MYV6	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:A8MYV6	C	From MGI
	GO:0006089	lactate metabolic process	MGI:MGI:3576386 PMID:15328538^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0006110	regulation of glycolysis	MGI:MGI:3709696 PMID:17437992^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:96552	P	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2176655 PMID:11782478^[11]	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:3056854 PMID:15456877^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0006879	cellular iron ion homeostasis	MGI:MGI:3695187 PMID:16787915^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000014	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0007595	lactation	MGI:MGI:2654263 PMID:12620994^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0008542	visual learning	MGI:MGI:2676530 PMID:12972594^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2677899	P	From MGI
	GO:0009434	microtubule-based flagellum	MGI:MGI:2158034 PMID:11818497^[31]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0010468	regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0010573	vascular endothelial growth factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0010575	positive regulation vascular endothelial growth factor production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0010634	positive regulation of epithelial cell migration	MGI:MGI:3772289 PMID:18037992^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010870	positive regulation of receptor biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0014850	response to muscle activity	MGI:MGI:3576386 PMID:15328538^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0021502	neural fold elevation formation	MGI:MGI:1337194 PMID:10328919^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0021987	cerebral cortex development	MGI:MGI:2676530 PMID:12972594^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2677899	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3039988 PMID:15073147^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3703383 PMID:16287860^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:109169	P	From MGI
	GO:0030502	negative regulation of bone mineralization	MGI:MGI:3777866 PMID:17181398^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	MGI:MGI:2153426 PMID:11691837^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679 MGI:MGI:2386649	P	From MGI
	GO:0031625	ubiquitin protein ligase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0032007	negative regulation of TOR signaling cascade	MGI:MGI:4830408 PMID:20808783^[34]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384429	P	From MGI
	GO:0032364	oxygen homeostasis	MGI:MGI:1195604 PMID:9436976^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0032364	oxygen homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0032403	protein complex binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	F	From MGI
	GO:0032909	regulation of transforming growth factor beta2 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0032963	collagen metabolic process	MGI:MGI:3772289 PMID:18037992^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0035035	histone acetyltransferase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0035162	embryonic hemopoiesis	MGI:MGI:3695187 PMID:16787915^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	MGI:MGI:4459348 PMID:20440072^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2677892	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:3709696 PMID:17437992^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042541	hemoglobin biosynthetic process	MGI:MGI:3695187 PMID:16787915^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3576386 PMID:15328538^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:3709696 PMID:17437992^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042826	histone deacetylase binding	MGI:MGI:3821919 PMID:19071119^[35]	IPI: Inferred from Physical Interaction	UniProtKB:P56524 UniProtKB:Q9UQL6	F	From MGI
	GO:0042981	regulation of apoptotic process	MGI:MGI:3056854 PMID:15456877^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:3777866 PMID:17181398^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0043524	negative regulation of neuron apoptotic process	MGI:MGI:2676530 PMID:12972594^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2677899	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:1306687 PMID:9368100^[36]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	MGI:MGI:2667513 PMID:12832481^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385358	P	From MGI
	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0045648	positive regulation of erythrocyte differentiation	MGI:MGI:3695187 PMID:16787915^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0045906	negative regulation of vasoconstriction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0045926	negative regulation of growth	MGI:MGI:2153426 PMID:11691837^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679 MGI:MGI:2386649	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3577779 PMID:15766748^[38]	IGI: Inferred from Genetic Interaction	MGI:MGI:88071 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3703197 PMID:17284606^[39]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5306879 PMID:21856340^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:82592 PMID:8702901^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:894004 PMID:9113979^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:88071	P	From MGI
	GO:0046716	muscle cell homeostasis	MGI:MGI:3576386 PMID:15328538^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0046886	positive regulation of hormone biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	F	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0048514	blood vessel morphogenesis	MGI:MGI:1261710 PMID:9606183^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2385358	P	From MGI
	GO:0048546	digestive tract morphogenesis	MGI:MGI:4830408 PMID:20808783^[34]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384429	P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:O35800	P	From MGI
	GO:0050790	regulation of catalytic activity	MGI:MGI:3576386 PMID:15328538^[27]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0051216	cartilage development	MGI:MGI:2153426 PMID:11691837^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679 MGI:MGI:2386649	P	From MGI
	GO:0051541	elastin metabolic process	MGI:MGI:3772289 PMID:18037992^[14]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051879	Hsp90 protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	F	From MGI
	GO:0060574	intestinal epithelial cell maturation	MGI:MGI:4830408 PMID:20808783^[34]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384429	P	From MGI
	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	MGI:MGI:2654263 PMID:12620994^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0061298	retina vasculature development in camera-type eye	MGI:MGI:4950335 PMID:21212189^[40]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:0071456	cellular response to hypoxia	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q16665	P	From MGI
	GO:0071542	dopaminergic neuron differentiation	MGI:MGI:3695975 PMID:17215402^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:103178	P	From MGI
	GO:0071542	dopaminergic neuron differentiation	MGI:MGI:3695975 PMID:17215402^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386679	P	From MGI
	GO:2001054	negative regulation of mesenchymal cell apoptotic process	MGI:MGI:1337194 PMID:10328919^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857719	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Saini Y et al. (2010) Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 298: L139-47 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cheng K et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 120: 2171-83 PubMed GONUTS page
↑ ^3.0 ^3.1 An HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta 1813: 2088-98 PubMed GONUTS page
↑ ^4.0 ^4.1 Zelzer E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131: 2161-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Compernolle V et al. (2003) Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res 60: 569-79 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Iyer NV et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Ryan HE et al. (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-15 PubMed GONUTS page
↑ Yu AY et al. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 103: 691-6 PubMed GONUTS page
↑ Kline DD et al. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A 99: 821-6 PubMed GONUTS page
↑ Mochizuki Y et al. (2002) Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. J Cell Sci 115: 175-83 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Lum JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21: 1037-49 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Li H et al. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J Biol Chem 271: 21262-7 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Higgins DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117: 3810-20 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Cowden Dahl KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 PubMed GONUTS page
↑ Kojima H et al. (2002) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc Natl Acad Sci U S A 99: 2170-4 PubMed GONUTS page
↑ Chen Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135: 2939-48 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Milosevic J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci 27: 412-21 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Biju MP et al. (2004) Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol 24: 9038-47 PubMed GONUTS page
↑ ^20.0 ^20.1 Ema M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94: 4273-8 PubMed GONUTS page
↑ Shao R et al. (2004) Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett 569: 293-300 PubMed GONUTS page
↑ Qi J et al. (2010) Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18: 23-38 PubMed GONUTS page
↑ Dang EV et al. (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146: 772-84 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Schipani E et al. (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15: 2865-76 PubMed GONUTS page
↑ Suliman HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104: 43-50 PubMed GONUTS page
↑ Kim HG et al. (2008) Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells. Biochem Biophys Res Commun 369: 666-71 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 Mason SD et al. (2004) Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2: e288 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Yoon D et al. (2006) Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem 281: 25703-11 PubMed GONUTS page
↑ ^29.0 ^29.1 Seagroves TN et al. (2003) HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130: 1713-24 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Tomita S et al. (2003) Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 23: 6739-49 PubMed GONUTS page
↑ Marti HH et al. (2002) Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis. Mol Endocrinol 16: 234-43 PubMed GONUTS page
↑ ^32.0 ^32.1 Kotch LE et al. (1999) Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209: 254-67 PubMed GONUTS page
↑ ^33.0 ^33.1 Komatsu DE et al. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J Bone Miner Res 22: 366-74 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Lussier CR et al. (2010) Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS One 5: e12378 PubMed GONUTS page
↑ Seo HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett 583: 55-60 PubMed GONUTS page
↑ Luo G et al. (1997) Molecular characterization of the murine Hif-1 alpha locus. Gene Expr 6: 287-99 PubMed GONUTS page
↑ Park SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 23: 4959-71 PubMed GONUTS page
↑ Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol 280: 59-72 PubMed GONUTS page
↑ Gruber M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 104: 2301-6 PubMed GONUTS page
↑ Caprara C et al. (2011) HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. Invest Ophthalmol Vis Sci 52: 2109-17 PubMed GONUTS page

[PMID:19915160-0] Saini Y et al. (2010) Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 298: L139-47 PubMed GONUTS page

[PMID:20440072-1] 2.0 ^2.1 ^2.2 Cheng K et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 120: 2171-83 PubMed GONUTS page

[PMID:21856340-2] 3.0 ^3.1 An HJ et al. (2011) The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. Biochim Biophys Acta 1813: 2088-98 PubMed GONUTS page

[PMID:15073147-3] 4.0 ^4.1 Zelzer E et al. (2004) VEGFA is necessary for chondrocyte survival during bone development. Development 131: 2161-71 PubMed GONUTS page

[PMID:14659802-4] 5.0 ^5.1 ^5.2 Compernolle V et al. (2003) Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res 60: 569-79 PubMed GONUTS page

[PMID:9436976-5] 6.0 ^6.1 ^6.2 ^6.3 Iyer NV et al. (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-62 PubMed GONUTS page

[PMID:9606183-6] 7.0 ^7.1 Ryan HE et al. (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-15 PubMed GONUTS page

[PMID:10074486-7] Yu AY et al. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 103: 691-6 PubMed GONUTS page

[PMID:11792862-8] Kline DD et al. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A 99: 821-6 PubMed GONUTS page

[PMID:11801735-9] Mochizuki Y et al. (2002) Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn. J Cell Sci 115: 175-83 PubMed GONUTS page

[PMID:11782478-10] 11.0 ^11.1 ^11.2 Woods SL & Whitelaw ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J Biol Chem 277: 10236-43 PubMed GONUTS page

[PMID:17437992-11] 12.0 ^12.1 ^12.2 ^12.3 Lum JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 21: 1037-49 PubMed GONUTS page

[PMID:8702901-12] 13.0 ^13.1 ^13.2 Li H et al. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha. J Biol Chem 271: 21262-7 PubMed GONUTS page

[PMID:18037992-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Higgins DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 117: 3810-20 PubMed GONUTS page

[PMID:16287860-14] 15.0 ^15.1 ^15.2 Cowden Dahl KD et al. (2005) Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol 25: 10479-91 PubMed GONUTS page

[PMID:11854513-15] Kojima H et al. (2002) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc Natl Acad Sci U S A 99: 2170-4 PubMed GONUTS page

[PMID:18653562-16] Chen Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135: 2939-48 PubMed GONUTS page

[PMID:17215402-17] 18.0 ^18.1 ^18.2 Milosevic J et al. (2007) Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling. J Neurosci 27: 412-21 PubMed GONUTS page

[PMID:15456877-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Biju MP et al. (2004) Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol 24: 9038-47 PubMed GONUTS page

[PMID:9113979-19] 20.0 ^20.1 Ema M et al. (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 94: 4273-8 PubMed GONUTS page

[PMID:15225651-20] Shao R et al. (2004) Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett 569: 293-300 PubMed GONUTS page

[PMID:20609350-21] Qi J et al. (2010) Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18: 23-38 PubMed GONUTS page

[PMID:21871655-22] Dang EV et al. (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146: 772-84 PubMed GONUTS page

[PMID:11691837-23] 24.0 ^24.1 ^24.2 ^24.3 Schipani E et al. (2001) Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15: 2865-76 PubMed GONUTS page

[PMID:15016652-24] Suliman HB et al. (2004) Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. Blood 104: 43-50 PubMed GONUTS page

[PMID:18295594-25] Kim HG et al. (2008) Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells. Biochem Biophys Res Commun 369: 666-71 PubMed GONUTS page

[PMID:15328538-26] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 Mason SD et al. (2004) Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2: e288 PubMed GONUTS page

[PMID:16787915-27] 28.0 ^28.1 ^28.2 ^28.3 Yoon D et al. (2006) Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem 281: 25703-11 PubMed GONUTS page

[PMID:12620994-28] 29.0 ^29.1 Seagroves TN et al. (2003) HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development 130: 1713-24 PubMed GONUTS page

[PMID:12972594-29] 30.0 ^30.1 ^30.2 Tomita S et al. (2003) Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol 23: 6739-49 PubMed GONUTS page

[PMID:11818497-30] Marti HH et al. (2002) Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis. Mol Endocrinol 16: 234-43 PubMed GONUTS page

[PMID:10328919-31] 32.0 ^32.1 Kotch LE et al. (1999) Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209: 254-67 PubMed GONUTS page

[PMID:17181398-32] 33.0 ^33.1 Komatsu DE et al. (2007) Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J Bone Miner Res 22: 366-74 PubMed GONUTS page

[PMID:20808783-33] 34.0 ^34.1 ^34.2 Lussier CR et al. (2010) Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS One 5: e12378 PubMed GONUTS page

[PMID:19071119-34] Seo HW et al. (2009) Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett 583: 55-60 PubMed GONUTS page

[PMID:9368100-35] Luo G et al. (1997) Molecular characterization of the murine Hif-1 alpha locus. Gene Expr 6: 287-99 PubMed GONUTS page

[PMID:12832481-36] Park SK et al. (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 23: 4959-71 PubMed GONUTS page

[PMID:15766748-37] Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol 280: 59-72 PubMed GONUTS page

[PMID:17284606-38] Gruber M et al. (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A 104: 2301-6 PubMed GONUTS page

[PMID:21212189-39] Caprara C et al. (2011) HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. Invest Ophthalmol Vis Sci 52: 2109-17 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hif1a ( synonyms: bHLHe78, HIF-1alpha, HIF1alpha, MOP1 )
Protein Name(s)	hypoxia inducible factor 1, alpha subunit,
External Links
MGI	MGI:106918

MGI:Hif1a

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