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MGI:Hhip
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hhip ( synonyms: Hhip1, Hip, Hip1 ) | |
| Protein Name(s) | Hedgehog-interacting protein, | |
| External Links | ||
| MGI | MGI:1341847 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1333378 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:1333378 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005975 |
carbohydrate metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:1333378 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007224 |
smoothened signaling pathway |
MGI:MGI:2450020 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450891 |
P |
From MGI |
||
| GO:0007405 |
neuroblast proliferation |
MGI:MGI:3511726 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:105373 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:2675247 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450891 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3511726 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:105373 |
P |
From MGI |
||
| GO:0009968 |
negative regulation of signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3511726 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016525 |
negative regulation of angiogenesis |
MGI:MGI:5284801 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0016901 |
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0040036 |
regulation of fibroblast growth factor receptor signaling pathway |
MGI:MGI:2450020 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450891 |
P |
From MGI |
||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
MGI:MGI:1333378 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
MGI:MGI:5284801 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048038 |
quinone binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0048705 |
skeletal system morphogenesis |
MGI:MGI:1333378 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055114 |
oxidation-reduction process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0060441 |
epithelial tube branching involved in lung morphogenesis |
MGI:MGI:2450020 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450891 |
P |
From MGI |
||
| GO:0097108 |
hedgehog family protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Chuang PT & McMahon AP (1999) Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Chuang PT et al. (2003) Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 17: 342-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Jeong J & McMahon AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132: 143-54 PubMed GONUTS page
- ↑ Kawahira H et al. (2003) Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 130: 4871-9 PubMed GONUTS page
- ↑ 5.0 5.1 Olsen CL et al. (2004) Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer 4: 43 PubMed GONUTS page
