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MGI:Hfe2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hfe2 ( synonyms: DL-M, hemojuvelin, HJV, Rgmc ) | |
| Protein Name(s) | hemochromatosis type 2 (juvenile) (human homolog), | |
| External Links | ||
| MGI | MGI:1916835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
MGI:MGI:3625588 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:3027667 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3027667 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015026 |
coreceptor activity |
MGI:MGI:3625588 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88177 |
F |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001012080 |
C |
From MGI |
||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3625588 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88177 |
P |
From MGI |
||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3625588 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587746 |
P |
From MGI |
||
| GO:0031225 |
anchored to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0336 |
C |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3625588 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88177 |
P |
From MGI |
||
| GO:0055072 |
iron ion homeostasis |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055072 |
iron ion homeostasis |
MGI:MGI:3587447 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3587747 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Babitt JL et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-9 PubMed GONUTS page
- ↑ 2.0 2.1 Niederkofler V et al. (2004) Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci 24: 808-18 PubMed GONUTS page
- ↑ Niederkofler V et al. (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180-6 PubMed GONUTS page
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