GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Heyl
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Heyl ( synonyms: bHLHb33, Hesr3, Hey3, Hrt3 ) | |
| Protein Name(s) | hairy/enhancer-of-split related with YRPW motif-like, | |
| External Links | ||
| MGI | MGI:1860511 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000979 |
RNA polymerase II core promoter sequence-specific DNA binding |
MGI:MGI:5285519 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000983 |
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity |
MGI:MGI:3603871 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000988 |
protein binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:5285519 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001106 |
RNA polymerase II transcription corepressor activity |
MGI:MGI:5285519 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003198 |
epithelial to mesenchymal transition involved in endocardial cushion formation |
MGI:MGI:3783952 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1341800 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1859988 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003714 |
transcription corepressor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3603871 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5285519 |
IPI: Inferred from Physical Interaction |
UniProtKB:P35428 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:1350427 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5285133 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1350427 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1350427 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:3576186 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007219 |
Notch signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007422 |
peripheral nervous system development |
MGI:MGI:4365702 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0035939 |
microsatellite binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:5285519 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:4365702 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:5285519 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3603871 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4365702 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050683 |
AF-1 domain binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0060766 |
negative regulation of androgen receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000824 |
negative regulation of androgen receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Jalali A et al. (2011) HeyL promotes neuronal differentiation of neural progenitor cells. J Neurosci Res 89: 299-309 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Fischer A et al. (2005) Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol 25: 8960-70 PubMed GONUTS page
- ↑ Fischer A et al. (2007) Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 100: 856-63 PubMed GONUTS page
- ↑ Steidl C et al. (2000) Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Genomics 66: 195-203 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Nakagawa O et al. (1999) HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol 216: 72-84 PubMed GONUTS page
- ↑ Kanno K & Ishiura S (2011) Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats. J Neurosci Res 89: 562-75 PubMed GONUTS page
- ↑ Chen L & Al-Awqati Q (2005) Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol 288: F939-52 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Mukhopadhyay A et al. (2009) HeyL regulates the number of TrkC neurons in dorsal root ganglia. Dev Biol 334: 142-51 PubMed GONUTS page
