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MGI:Hells
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hells ( synonyms: LSH, Lysh, PASG, proliferation-associated SNF2-like, YFK8 ) | |
| Protein Name(s) | helicase, lymphoid specific, | |
| External Links | ||
| MGI | MGI:106209 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000775 |
chromosome, centromeric region |
MGI:MGI:3041983 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001655 |
urogenital system development |
MGI:MGI:2178571 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178586 |
P |
From MGI |
||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3510059 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004386 |
helicase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0347 |
F |
From MGI |
||
| GO:0004386 |
helicase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2150845 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005721 |
centromeric heterochromatin |
MGI:MGI:3041983 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006306 |
DNA methylation |
MGI:MGI:2153312 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178586 |
P |
From MGI |
||
| GO:0006342 |
chromatin silencing |
MGI:MGI:3510059 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178586 |
P |
From MGI |
||
| GO:0006346 |
methylation-dependent chromatin silencing |
MGI:MGI:3573964 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:2178571 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178586 |
P |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007067 |
mitosis |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0498 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2178571 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010216 |
maintenance of DNA methylation |
MGI:MGI:3620346 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030098 |
lymphocyte differentiation |
MGI:MGI:2178571 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0031508 |
centromeric heterochromatin assembly |
MGI:MGI:3041983 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yan Q et al. (2003) Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin. Mol Cell Biol 23: 8416-28 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Geiman TM et al. (2001) Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta 1526: 211-20 PubMed GONUTS page
- ↑ 3.0 3.1 Huang J et al. (2004) Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res 32: 5019-28 PubMed GONUTS page
- ↑ Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet 10: 1995-2011 PubMed GONUTS page
- ↑ Dennis K et al. (2001) Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev 15: 2940-4 PubMed GONUTS page
- ↑ Fan T et al. (2005) Lsh controls silencing of the imprinted Cdkn1c gene. Development 132: 635-44 PubMed GONUTS page
- ↑ Sun LQ et al. (2004) Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 18: 1035-46 PubMed GONUTS page
