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MGI:Hcls1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Hcls1 ( synonyms: HS1 )
Protein Name(s) hematopoietic cell specific Lyn substrate 1,
External Links
MGI MGI:104568

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005515

protein binding

MGI:MGI:3694161
PMID:10713104[1]

IPI: Inferred from Physical Interaction

UniProtKB:P06240
UniProtKB:P25911
UniProtKB:P39688

F

From MGI

GO:0005634

nucleus

MGI:MGI:3694161
PMID:10713104[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3694161
PMID:10713104[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EVW7

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:E7EVW7

C

From MGI

GO:0008284

positive regulation of cell proliferation

MGI:MGI:3694161
PMID:10713104[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0009725

response to hormone stimulus

MGI:MGI:3694161
PMID:10713104[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0017124

SH3 domain binding

MGI:MGI:1326779
PMID:9126384[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0017124

SH3 domain binding

MGI:MGI:3844204
PMID:19064729[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q91WK7

F

From MGI

GO:0030218

erythrocyte differentiation

MGI:MGI:3694161
PMID:10713104[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0032403

protein complex binding

MGI:MGI:3844204
PMID:19064729[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q91WK7
UniProtKB:P25911

F

From MGI

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

MGI:MGI:3694161
PMID:10713104[1]

IMP: Inferred from Mutant Phenotype

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ingley E et al. (2000) HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells. J Biol Chem 275: 7887-93 PubMed GONUTS page
  2. Yamabhai M & Kay BK (1997) Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Anal Biochem 247: 143-51 PubMed GONUTS page
  3. 3.0 3.1 Samuels AL et al. (2009) Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood 113: 3845-56 PubMed GONUTS page
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