GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Hbegf
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Hbegf ( synonyms: Dtr, HB-EGF, Hegfl ) | |
| Protein Name(s) | heparin-binding EGF-like growth factor, | |
| External Links | ||
| MGI | MGI:96070 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:3693406 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0001832 |
blastocyst growth |
MGI:MGI:1333098 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0005154 |
epidermal growth factor receptor binding |
MGI:MGI:3690187 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005154 |
epidermal growth factor receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:1326990 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:1326990 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
MGI:MGI:2654964 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:2654964 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2655703 |
P |
From MGI |
||
| GO:0008083 |
growth factor activity |
MGI:MGI:3690187 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:3690187 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016477 |
cell migration |
MGI:MGI:3580979 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030307 |
positive regulation of cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035313 |
wound healing, spreading of epidermal cells |
MGI:MGI:3580979 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043499 |
eukaryotic cell surface binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048661 |
positive regulation of smooth muscle cell proliferation |
MGI:MGI:3690187 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051545 |
negative regulation of elastin biosynthetic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051549 |
positive regulation of keratinocyte migration |
MGI:MGI:3580979 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051897 |
positive regulation of protein kinase B signaling cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090303 |
positive regulation of wound healing |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ongusaha PP et al. (2004) HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res 64: 5283-90 PubMed GONUTS page
- ↑ Paria BC et al. (1999) Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Development 126: 1997-2005 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Higashiyama S et al. (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251: 936-9 PubMed GONUTS page
- ↑ 4.0 4.1 Izumi Y et al. (1998) A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J 17: 7260-72 PubMed GONUTS page
- ↑ 5.0 5.1 Iwamoto R et al. (2003) Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A 100: 3221-6 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Shirakata Y et al. (2005) Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci 118: 2363-70 PubMed GONUTS page
