MGI:Hand2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000790	nuclear chromatin	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	C	From MGI
	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	F	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0037	P	From MGI
	GO:0001701	in utero embryonic development	MGI:MGI:892134 PMID:9171826^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0001947	heart looping	MGI:MGI:892134 PMID:9171826^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0001967	suckling behavior	MGI:MGI:3714871 PMID:17531968^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0003007	heart morphogenesis	MGI:MGI:2153294 PMID:11784028^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0003219	cardiac right ventricle formation	MGI:MGI:1926848 PMID:11076755^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	MGI:MGI:4453274 PMID:20144608^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3803647 MGI:MGI:2386570	P	From MGI
	GO:0003266	regulation of secondary heart field cardioblast proliferation	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From MGI
	GO:0003680	AT DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	F	From MGI
	GO:0003713	transcription coactivator activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2429440 PMID:12070084^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P15806	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3053473 PMID:15351717^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P15806 UniProtKB:Q61286 UniProtKB:Q60722	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3687816 PMID:10924525^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P15806 UniProtKB:Q64279	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688344 PMID:15102471^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q99N72	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5294529 PMID:20599664^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q15327	F	From MGI
	GO:0005634	nucleus	MGI:MGI:3830408 PMID:19144722^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:4362015 PMID:11812799^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:3053473 PMID:15351717^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:2153294 PMID:11784028^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007507	heart development	MGI:MGI:3513216 PMID:15576406^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:103577	P	From MGI
	GO:0007512	adult heart development	MGI:MGI:892134 PMID:9171826^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:3830408 PMID:19144722^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q08775	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4362015 PMID:11812799^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P15806-1	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	F	From MGI
	GO:0010463	mesenchymal cell proliferation	MGI:MGI:3848084 PMID:19341725^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0014032	neural crest cell development	MGI:MGI:1277800 PMID:9671575^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	F	From MGI
	GO:0030154	cell differentiation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	From MGI
	GO:0033613	activating transcription factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	F	From MGI
	GO:0042475	odontogenesis of dentin-containing tooth	MGI:MGI:3765375 PMID:17764670^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:103577	P	From MGI
	GO:0042733	embryonic digit morphogenesis	MGI:MGI:2429440 PMID:12070084^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4362015 PMID:11812799^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q61039	F	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:3848084 PMID:19341725^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0043234	protein complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	C	From MGI
	GO:0043392	negative regulation of DNA binding	MGI:MGI:3830408 PMID:19144722^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:3830408 PMID:19144722^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:2429440 PMID:12070084^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:98510	F	From MGI
	GO:0043586	tongue development	MGI:MGI:3714871 PMID:17531968^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:3830408 PMID:19144722^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:3830408 PMID:19144722^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2653307	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2429440 PMID:12070084^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:98510	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3703388 PMID:16145670^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4362015 PMID:11812799^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4362015 PMID:11812799^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P61295	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4453274 PMID:20144608^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:98510	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:3607868 PMID:12392994^[19]	IPI: Inferred from Physical Interaction	UniProtKB:P42582	F	From MGI
	GO:0048485	sympathetic nervous system development	MGI:MGI:3703388 PMID:16145670^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048538	thymus development	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048935	peripheral nervous system neuron development	MGI:MGI:3703388 PMID:16145670^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060021	palate development	MGI:MGI:3714871 PMID:17531968^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0060021	palate development	MGI:MGI:3848084 PMID:19341725^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149	P	From MGI
	GO:0060485	mesenchyme development	MGI:MGI:3765375 PMID:17764670^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:103577	P	From MGI
	GO:0060536	cartilage morphogenesis	MGI:MGI:3765375 PMID:17764670^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:103577	P	From MGI
	GO:0060982	coronary artery morphogenesis	MGI:MGI:4948416 PMID:21350214^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149 MGI:MGI:4838016	P	From MGI
	GO:0061032	visceral serous pericardium development	MGI:MGI:4948416 PMID:21350214^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3715149 MGI:MGI:3801682	P	From MGI
	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061325	cell proliferation involved in outflow tract morphogenesis	MGI:MGI:4453274 PMID:20144608^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3803647 MGI:MGI:2386570	P	From MGI
	GO:0061371	determination of heart left/right asymmetry	MGI:MGI:1203269 PMID:9576835^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857639	P	From MGI
	GO:0070888	E-box binding	MGI:MGI:4453274 PMID:20144608^[5]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0070888	E-box binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	F	From MGI
	GO:2000679	positive regulation of transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P61296	P	From MGI
	GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis	MGI:MGI:4413411 PMID:19008477^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
contributes_to	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4362015 PMID:11812799^[13]	IDA: Inferred from Direct Assay		F	From MGI
contributes_to	GO:0070888	E-box binding	MGI:MGI:4362015 PMID:11812799^[13]	IDA: Inferred from Direct Assay		F	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Srivastava D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16: 154-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Morikawa Y et al. (2007) Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol 307: 114-26 PubMed GONUTS page
↑ ^3.0 ^3.1 Yamagishi H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239: 190-203 PubMed GONUTS page
↑ McFadden DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-41 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Holler KL et al. (2010) Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol 341: 291-304 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Morikawa Y & Cserjesi P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103: 1422-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 McFadden DG et al. (2002) Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development 129: 3077-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Murakami M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun 323: 168-74 PubMed GONUTS page
↑ Firulli BA et al. (2000) The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem 275: 33567-73 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys 502: 60-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Funato N et al. (2009) Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136: 615-25 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Dai YS & Cserjesi P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J Biol Chem 277: 12604-12 PubMed GONUTS page
↑ McFadden DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page
↑ Thomas T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125: 3005-14 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Barbosa AC et al. (2007) Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310: 154-68 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Morikawa Y et al. (2005) The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev Dyn 234: 613-21 PubMed GONUTS page
↑ Thattaliyath BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol 34: 1335-44 PubMed GONUTS page
↑ ^20.0 ^20.1 Barnes RM et al. (2011) Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res 108: 940-9 PubMed GONUTS page
↑ Thomas T et al. (1998) The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol 196: 228-36 PubMed GONUTS page

[PMID:9171826-0] 1.0 ^1.1 ^1.2 Srivastava D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16: 154-60 PubMed GONUTS page

[PMID:17531968-1] 2.0 ^2.1 ^2.2 Morikawa Y et al. (2007) Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol 307: 114-26 PubMed GONUTS page

[PMID:11784028-2] 3.0 ^3.1 Yamagishi H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239: 190-203 PubMed GONUTS page

[PMID:11076755-3] McFadden DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127: 5331-41 PubMed GONUTS page

[PMID:20144608-4] 5.0 ^5.1 ^5.2 ^5.3 Holler KL et al. (2010) Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol 341: 291-304 PubMed GONUTS page

[PMID:19008477-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Morikawa Y & Cserjesi P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ Res 103: 1422-9 PubMed GONUTS page

[PMID:12070084-6] 7.0 ^7.1 ^7.2 ^7.3 McFadden DG et al. (2002) Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development 129: 3077-88 PubMed GONUTS page

[PMID:15351717-7] 8.0 ^8.1 Murakami M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun 323: 168-74 PubMed GONUTS page

[PMID:10924525-8] Firulli BA et al. (2000) The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem 275: 33567-73 PubMed GONUTS page

[PMID:15102471-9] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:20599664-10] Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys 502: 60-7 PubMed GONUTS page

[PMID:19144722-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Funato N et al. (2009) Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136: 615-25 PubMed GONUTS page

[PMID:11812799-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Dai YS & Cserjesi P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J Biol Chem 277: 12604-12 PubMed GONUTS page

[PMID:15576406-13] McFadden DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201 PubMed GONUTS page

[PMID:19341725-14] 15.0 ^15.1 ^15.2 Xiong W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-41 PubMed GONUTS page

[PMID:9671575-15] Thomas T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125: 3005-14 PubMed GONUTS page

[PMID:17764670-16] 17.0 ^17.1 ^17.2 Barbosa AC et al. (2007) Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310: 154-68 PubMed GONUTS page

[PMID:16145670-17] 18.0 ^18.1 ^18.2 Morikawa Y et al. (2005) The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev Dyn 234: 613-21 PubMed GONUTS page

[PMID:12392994-18] Thattaliyath BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol 34: 1335-44 PubMed GONUTS page

[PMID:21350214-19] 20.0 ^20.1 Barnes RM et al. (2011) Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res 108: 940-9 PubMed GONUTS page

[PMID:9576835-20] Thomas T et al. (1998) The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol 196: 228-36 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Hand2 ( synonyms: bHLHa26, dHAND, Ehand2, Hed, Thing2 )
Protein Name(s)	heart and neural crest derivatives expressed transcript 2,
External Links
MGI	MGI:103580

MGI:Hand2

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