MGI:H2-DMa

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0491	P	From MGI
	GO:0005515	protein binding	MGI:MGI:1290041 PMID:9768758^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P70238	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2671681 PMID:9492004^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005764	lysosome	MGI:MGI:3033877 PMID:7584146^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005764	lysosome	MGI:MGI:3033879 PMID:11854359^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005765	lysosomal membrane	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005770	late endosome	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005770	late endosome	MGI:MGI:3033877 PMID:7584146^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005771	multivesicular body	MGI:MGI:3033879 PMID:11854359^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006461	protein complex assembly	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010008	endosome membrane	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0015031	protein transport	MGI:MGI:3033875 PMID:8890155^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0812	C	From MGI
	GO:0016064	immunoglobulin mediated immune response	MGI:MGI:2153656 PMID:11714799^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0019882	antigen processing and presentation	MGI:MGI:1933465 PMID:11148202^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019882	antigen processing and presentation	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019882	antigen processing and presentation	MGI:MGI:3033877 PMID:7584146^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019882	antigen processing and presentation	MGI:MGI:3033881 PMID:9432982^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	MGI:MGI:2153656 PMID:11714799^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	MGI:MGI:3033882 PMID:11027433^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	MGI:MGI:79110 PMID:8598040^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384509	P	From MGI
	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	MGI:MGI:79111 PMID:8598041^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0042613	MHC class II protein complex	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0491	C	From MGI
	GO:0045059	positive thymic T cell selection	MGI:MGI:3033881 PMID:9432982^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0045059	positive thymic T cell selection	MGI:MGI:79110 PMID:8598040^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384509	P	From MGI
	GO:0045059	positive thymic T cell selection	MGI:MGI:79111 PMID:8598041^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0045059	positive thymic T cell selection	MGI:MGI:79272 PMID:8638109^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0045582	positive regulation of T cell differentiation	MGI:MGI:3033881 PMID:9432982^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0045582	positive regulation of T cell differentiation	MGI:MGI:79110 PMID:8598040^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384509	P	From MGI
	GO:0045582	positive regulation of T cell differentiation	MGI:MGI:79111 PMID:8598041^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0045582	positive regulation of T cell differentiation	MGI:MGI:79272 PMID:8638109^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0048839	inner ear development	MGI:MGI:5140238 PMID:21795542^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050778	positive regulation of immune response	MGI:MGI:2153656 PMID:11714799^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0051085	chaperone mediated protein folding requiring cofactor	MGI:MGI:1933465 PMID:11148202^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051085	chaperone mediated protein folding requiring cofactor	MGI:MGI:2153656 PMID:11714799^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
	GO:0051085	chaperone mediated protein folding requiring cofactor	MGI:MGI:3033762 PMID:7985028^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051085	chaperone mediated protein folding requiring cofactor	MGI:MGI:79111 PMID:8598041^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861933	P	From MGI
	GO:0051085	chaperone mediated protein folding requiring cofactor	MGI:MGI:79272 PMID:8638109^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2652160	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fremont DH et al. (1998) Crystal structure of mouse H2-M. Immunity 9: 385-93 PubMed GONUTS page
↑ Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lindstedt R et al. (1995) The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity 3: 561-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med 195: 461-72 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266: 1569-73 PubMed GONUTS page
↑ Liljedahl M et al. (1996) HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J 15: 4817-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Alfonso C et al. (2001) The impact of H2-DM on humoral immune responses. J Immunol 167: 6348-55 PubMed GONUTS page
↑ ^8.0 ^8.1 Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem 276: 11086-91 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med 187: 245-51 PubMed GONUTS page
↑ Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer 83: 1192-201 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84: 531-41 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84: 543-50 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science 271: 1278-81 PubMed GONUTS page
↑ Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci 31: 10903-18 PubMed GONUTS page

[PMID:9768758-0] Fremont DH et al. (1998) Crystal structure of mouse H2-M. Immunity 9: 385-93 PubMed GONUTS page

[PMID:9492004-1] Liljedahl M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8: 233-43 PubMed GONUTS page

[PMID:7584146-2] 3.0 ^3.1 ^3.2 Lindstedt R et al. (1995) The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity 3: 561-72 PubMed GONUTS page

[PMID:11854359-3] 4.0 ^4.1 Lankar D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J Exp Med 195: 461-72 PubMed GONUTS page

[PMID:7985028-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Karlsson L et al. (1994) Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266: 1569-73 PubMed GONUTS page

[PMID:8890155-5] Liljedahl M et al. (1996) HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J 15: 4817-24 PubMed GONUTS page

[PMID:11714799-6] 7.0 ^7.1 ^7.2 ^7.3 Alfonso C et al. (2001) The impact of H2-DM on humoral immune responses. J Immunol 167: 6348-55 PubMed GONUTS page

[PMID:11148202-7] 8.0 ^8.1 Walter W et al. (2001) H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem 276: 11086-91 PubMed GONUTS page

[PMID:9432982-8] 9.0 ^9.1 ^9.2 Kovats S et al. (1998) Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J Exp Med 187: 245-51 PubMed GONUTS page

[PMID:11027433-9] Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer 83: 1192-201 PubMed GONUTS page

[PMID:8598040-10] 11.0 ^11.1 ^11.2 Miyazaki T et al. (1996) Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84: 531-41 PubMed GONUTS page

[PMID:8598041-11] 12.0 ^12.1 ^12.2 ^12.3 Martin WD et al. (1996) H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84: 543-50 PubMed GONUTS page

[PMID:8638109-12] 13.0 ^13.1 ^13.2 Fung-Leung WP et al. (1996) Antigen presentation and T cell development in H2-M-deficient mice. Science 271: 1278-81 PubMed GONUTS page

[PMID:21795542-13] Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci 31: 10903-18 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	H2-DMa ( synonyms: H-2Ma, H2-M alpha, H2-Ma )
Protein Name(s)	histocompatibility 2, class II, locus DMa,
External Links
MGI	MGI:95921

MGI:H2-DMa

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